snap_masked-nMf.1.1.scaf16370-processed-gene-0.2 (Meloidogyne floridensis)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF03165 (MH1) IPR003619 snap_masked-nMf.1.1.scaf16370-processed-gene-0.2 T325904_2.00 WormBase:ParaSite (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NfI
M03968_2.00 		Drosophila melanogaster
YTGGCDNNNHGCCAR
YTGGCDNNNHGCCAR		 SELEX
Nitta et al.(2015)
NfI_1 		0.710 0.710
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
snap_masked-nMf.1.1.scaf16370-processed-gene-0.2-mRNA-1 SMAD 10 85

Links

Other SMAD family TFs
Other Meloidogyne floridensis TFs

1 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
TELCIR_04049 Teladorsagia circumcincta TELCIR_04049 I 0.746