CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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cic
(
Drosophila melanogaster
)
Sox
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00505 (HMG_box)
IPR000910
FBgn0262582
T329829_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including dorsal appendage formation; regionalization; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including extended germ band embryo; eye disc; and ventral ectoderm. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 45. Orthologous to human CIC (capicua transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
cic
M06452_2.00
Drosophila melanogaster
YYCATTSA
TSAATGRR
B1H
Zhu et al.(2011)
cic_SANGER_5_FBgn0028386
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Cic
M00195_2.00
Mus musculus
NNTGCTGABN
NVTCAGCANN
PBM
Badis et al.(2009)
Cic_3454
0.680
0.768
gei-3
M00711_2.00
Caenorhabditis elegans
NWNWMWDN
NHWKWNWN
PBM
Narasimhan et al.(2015)
pTH10038
0.647
0.725
ROX1
M00070_2.00
Saccharomyces cerevisiae
NRAACAATWNN
NNWATTGTTYN
PBM
Badis et al.(2008)
ROX1_2099
0.440
0.377
ROX1
M07498_2.00
Saccharomyces cerevisiae
YYHATTGTTYTS
SARAACAATDRR
PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0371.1
0.440
0.377
ROX1
M08607_2.00
Saccharomyces cerevisiae
BYATTGTN
NACAATRV
Misc
DeBoer et al.(2011)
YPR065W_1396
0.440
0.377
ROX1
M11346_2.00
Saccharomyces cerevisiae
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
F$ROX1_Q6_01
0.440
0.377
ROX1
M11347_2.00
Saccharomyces cerevisiae
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
F$ROX1_Q6
0.440
0.377
BBX
M05763_2.00
Homo sapiens
TGAWCDNYGWTCA
TGAWCRNHGWTCA
SELEX
Yin et al.(2017)
BBX_eDBD_HT-SELEX
0.430
0.478
BBX
M05764_2.00
Homo sapiens
TGAACDNYGTTCA
TGAACRNHGTTCA
SELEX
Yin et al.(2017)
BBX_eDBD_Methyl-HT-SELEX
0.430
0.478
For this family, TFs with SR scores >
0.415
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
FBpp0293563
Sox
490
558
IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWK
FBpp0293564
Sox
490
558
IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWK
FBpp0293565
Sox
490
558
IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWK
FBpp0293566
Sox
1228
1296
IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWK
FBpp0306420
Sox
1232
1300
IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWK
FBpp0306421
Sox
338
406
IRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWK
Links
Other
Sox
family TFs
Other
Drosophila melanogaster
TFs
464 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy