augustus_masked-nMf.1.1.scaf01778-processed-gene-0.2 (Meloidogyne floridensis)
Sox

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00505 (HMG_box) IPR000910 augustus_masked-nMf.1.1.scaf01778-processed-gene-0.2 T336076_2.00 WormBase:ParaSite (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
augustus_masked-nMf.1.1.scaf01778-processed-gene-0.2-mRNA-1 Sox 62 130
augustus_masked-nMf.1.1.scaf01778-processed-gene-0.2-mRNA-1 Sox 148 216

Links

Other Sox family TFs
Other Meloidogyne floridensis TFs

155 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
genemark-nMf.1.1.scaf06964-processed-gene-0.3 Meloidogyne floridensis genemark-nMf.1.1.scaf06964-processed-gene-0.3 N 0.741
L893_g5947 Steinernema glaseri L893_g5947 N 0.660
SMUV_0000232601 Syphacia muris SMUV_0000232601 N 0.660
L892_g17551 Steinernema scapterisci L892_g17551 N 0.660
L596_g22130 Steinernema carpocapsae L596_g22130 N 0.660
ASU_03902 Ascaris suum ASU_03902 N 0.657
PEQ_0000150901 Parascaris equorum PEQ_0000150901 N 0.657
EVEC_0000577301 Enterobius vermicularis EVEC_0000577301 N 0.657
TCLT_0000879501 Thelazia callipaeda TCLT_0000879501 N 0.657
TCNE_0000567001 Toxocara canis TCNE_0000567001 N 0.657
L889_g13533 Steinernema feltiae L889_g13533 N 0.655
MhA1_Contig113.frz3.gene9 Meloidogyne hapla MhA1_Contig113.frz3.gene9 N 0.655
PTRK_0000986200 Parastrongyloides trichosuri PTRK_0000986200 N 0.653
SPAL_0001030300 Strongyloides papillosus SPAL_0001030300 N 0.653
SSTP_0000371800 Strongyloides stercoralis SSTP_0000371800 N 0.653
Bm4180 Brugia malayi Bm4180 N 0.653
nAv.1.0.1.g02101 Acanthocheilonema viteae nAv.1.0.1.g02101 N 0.653
EEL_0000068601 Elaeophora elaphi EEL_0000068601 N 0.653
WBGene00245261 Onchocerca volvulus WBGene00245261 N 0.653
LOAG_04936 Loa loa LOAG_04936 N 0.653
SVE_0494300 Strongyloides venezuelensis SVE_0494300 N 0.653
nDi.2.2.2.g04979 Dirofilaria immitis nDi.2.2.2.g04979 N 0.653
Minc03268 Meloidogyne incognita Minc03268 N 0.652
Minc08988 Meloidogyne incognita Minc08988 N 0.652
DME_0001055201 Dracunculus medinensis DME_0001055201 N 0.646
RSKR_0000605700 Rhabditophanes kr3021 RSKR_0000605700 N 0.640
ACOC_0000768601 Angiostrongylus costaricensis ACOC_0000768601 N 0.638
HCOI00860100 Haemonchus contortus HCOI00860100 N 0.638
NECAME_09126 Necator americanus NECAME_09126 N 0.638
TELCIR_07111 Teladorsagia circumcincta TELCIR_07111 N 0.638
NBR_0000911001 Nippostrongylus brasiliensis NBR_0000911001 N 0.638
Hba_13817 Heterorhabditis bacteriophora Hba_13817 N 0.635
WUBG_12099 Wuchereria bancrofti WUBG_12099 N 0.632
ANCCAN_10156 Ancylostoma caninum ANCCAN_10156 N 0.630
Ppa-hmg-1.2 Pristionchus pacificus PPA02361 N 0.630
scaffold580-EXSNAP2012.5 Pristionchus exspectatus scaffold580-EXSNAP2012.5 N 0.630
D918_07195 Trichuris suis D918_07195 N 0.626
TTRE_0000338301 Trichuris trichiura TTRE_0000338301 N 0.626
ASIM_0000048401 Anisakis simplex ASIM_0000048401 N 0.625
SBAD_0000405201 Soboliphyme baturini SBAD_0000405201 N 0.613
TMUE_s0235000800 Trichuris muris TMUE_s0235000800 N 0.611
D917_08189 Trichinella nativa D917_08189 N 0.611
CBN17977 Caenorhabditis brenneri CBN17977 N 0.609
CJA09678 Caenorhabditis japonica CJA09678 N 0.609
CBG17468 Caenorhabditis briggsae CBG17468 N 0.609
hmg-1.2 Caenorhabditis elegans WBGene00001972 N 0.605
Minc01077 Meloidogyne incognita Minc01077 N 0.603
BXY_1555400 Bursaphelenchus xylophilus BXY_1555400 N 0.589
nLs.2.1.2.g00300 Litomosoides sigmodontis nLs.2.1.2.g00300 N 0.589
ANCCEY_10333 Ancylostoma ceylanicum ANCCEY_10333 N 0.582
nRc.2.0.1.g43473 Romanomermis culicivorax nRc.2.0.1.g43473 N 0.579
CJA42049 Caenorhabditis japonica CJA42049 N 0.578
EFV53345 Trichinella spiralis EFV53345 N 0.576
EFV57410 Trichinella spiralis EFV57410 N 0.573
D917_01254 Trichinella nativa D917_01254 N 0.573
ACAC_0001052301 Angiostrongylus cantonensis ACAC_0001052301 N 0.568
CRE02943 Caenorhabditis remanei CRE02943 N 0.564
GPUH_0001544201 Gongylonema pulchrum GPUH_0001544201 N 0.549
TELCIR_06008 Teladorsagia circumcincta TELCIR_06008 N 0.506
EmuJ_001049000 Echinococcus multilocularis EmuJ_001049000 N 0.500
TsM_000115400 Taenia solium TsM_000115400 N 0.500
MCOS_0000526101 Mesocestoides corti MCOS_0000526101 N 0.497
fgenesh2_pm.scaffold_24000033 Branchiostoma floridae fgenesh2_pm.scaffold_24000033 N 0.488
PXEA_0002175501 Protopolystoma xenopodis PXEA_0002175501 N 0.485
SROB_0000153901 Schistosoma rodhaini SROB_0000153901 N 0.483
Smp_000980 Schistosoma mansoni Smp_000980 N 0.483
SMTD_0001194601 Schistosoma mattheei SMTD_0001194601 N 0.483
SCUD_0000020101 Schistosoma curassoni SCUD_0000020101 N 0.483
HNAJ_0001249801 Hymenolepis nana HNAJ_0001249801 N 0.482
HmN_000466000 Hymenolepis microstoma HmN_000466000 N 0.482
HDID_0000237901 Hymenolepis diminuta HDID_0000237901 N 0.482
CGI_10023724 Crassostrea gigas CGI_10023724 N 0.482
CapteG158220 Capitella teleta CapteG158220 N 0.479
T265_12733 Opisthorchis viverrini T265_12733 N 0.474
BXY_1714600 Bursaphelenchus xylophilus BXY_1714600 N 0.474
HelroG157878 Helobdella robusta HelroG157878 N 0.471
SMU15030256 Schmidtea mediterranea SMU15030256 N 0.469
ECANG7_02036 Echinococcus canadensis ECANG7_02036 N 0.463
TTAC_0000225801 Hydatigera taeniaeformis TTAC_0000225801 N 0.463
ENSAMXG00000014031 Astyanax mexicanus ENSAMXG00000014031 N 0.458
AAI68534 Xenopus tropicalis AAI68534 N 0.457
D915_00818 Fasciola hepatica D915_00818 N 0.456
PXEA_0000637001 Protopolystoma xenopodis PXEA_0000637001 N 0.451
AMIN005344 Anopheles minimus AMIN005344 N 0.448
ASIS000124 Anopheles sinensis ASIS000124 N 0.448
AMEM017336 Anopheles merus AMEM017336 N 0.448
AARA010318 Anopheles arabiensis AARA010318 N 0.448
AALB006743 Anopheles albimanus AALB006743 N 0.448
AGAP000005 Anopheles gambiae AGAP000005 N 0.448
AMEC021909 Anopheles melas AMEC021909 N 0.448
Sjc_0031360 Schistosoma japonicum Sjc_0031360 N 0.448
ADAC001494 Anopheles darlingi ADAC001494 N 0.448
AAEL011380 Aedes aegypti AAEL011380 N 0.448
AATE018776 Anopheles atroparvus AATE018776 N 0.448
ACUA021022 Anopheles culicifacies ACUA021022 N 0.448
AFUN010134 Anopheles funestus AFUN010134 N 0.448
AMAM015540 Anopheles maculatus AMAM015540 N 0.448
ISCW017350 Ixodes scapularis ISCW017350 N 0.448
AFAF003948 Anopheles farauti AFAF003948 N 0.448
AEPI002924 Anopheles epiroticus AEPI002924 N 0.448
ADIR011701 Anopheles dirus ADIR011701 N 0.448
ENSPFOG00000008464 Poecilia formosa ENSPFOG00000008464 N 0.446
SMAR013695 Strigamia maritima SMAR013695 N 0.446
tetur02g08260 Tetranychus urticae tetur02g08260 N 0.443
ENSOCUG00000021132 Oryctolagus cuniculus ENSOCUG00000021132 N 0.440
tetur02g08340 Tetranychus urticae tetur02g08340 N 0.439
Sakowv30042012m.g Saccoglossus kowalevskii Sakowv30042012m.g N 0.439
hmg1/2 Ciona intestinalis ENSCING00000004075 N 0.437
SSLN_0000493501 Schistocephalus solidus SSLN_0000493501 N 0.436
DILT_0001497901 Diphyllobothrium latum DILT_0001497901 N 0.436
hmgb2a Danio rerio ENSDARG00000029722 N 0.435
hmgb1a Takifugu rubripes ENSTRUG00000008452 N 0.434
CpipJ_CPIJ014043 Culex pipiens CpipJ_CPIJ014043 N 0.434
CPIJ014043 Culex quinquefasciatus CPIJ014043 N 0.434
RGD1561694 Rattus norvegicus ENSRNOG00000029107 N 0.432
Cflo_05895--XP_001121384.1_APIME Camponotus floridanus Cflo_05895--XP_001121384.1_APIME N 0.432
Hmgb2 Rattus norvegicus ENSRNOG00000033321 N 0.432
Hsal_13110--XP_001121384.1_APIME Harpegnathos saltator Hsal_13110--XP_001121384.1_APIME N 0.432
Hmgb2l1 Rattus norvegicus ENSRNOG00000013167 N 0.432
HelroG87827 Helobdella robusta HelroG87827 N 0.431
ENSCSAVG00000000341 Ciona savignyi ENSCSAVG00000000341 N 0.430
YQE_03203 Dendroctonus ponderosae YQE_03203 N 0.429
ACEP16613 Atta cephalotes ACEP16613 N 0.428
SINV22586 Solenopsis invicta SINV22586 N 0.428
NV15664 Nasonia vitripennis NV15664 N 0.428
hmgb1b Gasterosteus aculeatus ENSGACG00000011447 N 0.426
ENSOARG00000015382 Ovis aries ENSOARG00000015382 N 0.425
SSLN_0001302101 Schistocephalus solidus SSLN_0001302101 N 0.425
ENSOARG00000015955 Ovis aries ENSOARG00000015955 N 0.425
Myotis_brandtii_Hmgb2_10018437 Myotis brandtii Myotis_brandtii_Hmgb2_10018437 N 0.425
ENSPANG00000007527 Papio anubis ENSPANG00000007527 N 0.425
ENSOARG00000010383 Ovis aries ENSOARG00000010383 N 0.425
DAPPUDRAFT_232871 Daphnia pulex DAPPUDRAFT_232871 N 0.424
T265_10726 Opisthorchis viverrini T265_10726 N 0.424
ACYPI007949 Acyrthosiphon pisum ACYPI007949 N 0.422
PXEA_0000566701 Protopolystoma xenopodis PXEA_0000566701 N 0.422
HelroG157726 Helobdella robusta HelroG157726 N 0.421
Aqu1.227714 Amphimedon queenslandica Aqu1.227714 N 0.421
GE17263 Drosophila yakuba FBgn0234741 N 0.420
AQUA004962 Anopheles quadriannulatus AQUA004962 N 0.420
GD17278 Drosophila simulans FBgn0188840 N 0.420
GG17955 Drosophila erecta FBgn0110175 N 0.420
Dsp1 Drosophila melanogaster FBgn0011764 N 0.420
ENSOCUG00000004133 Oryctolagus cuniculus ENSOCUG00000004133 N 0.420
GA11488 Drosophila pseudoobscura FBgn0071539 N 0.420
GF19115 Drosophila ananassae FBgn0096126 N 0.420
SMU15027649 Schmidtea mediterranea SMU15027649 N 0.419
ENSFCAG00000028961 Felis catus ENSFCAG00000028961 N 0.419
ENSAMXG00000014832 Astyanax mexicanus ENSAMXG00000014832 N 0.418
GI10980 Drosophila mojavensis FBgn0133743 N 0.416
LCUP007363 Lucilia cuprina LCUP007363 N 0.416
GPLIN_000727200 Globodera pallida GPLIN_000727200 N 0.416
GK25058 Drosophila willistoni FBgn0227017 N 0.416
GJ19445 Drosophila virilis FBgn0206588 N 0.416
GH12282 Drosophila grimshawi FBgn0119761 N 0.416