STAT1 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000115415 T337444_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT1
M08013_2.00
Homo sapiens
NBBNBTTCCHRGAADNSHNNN

NNNDSNHTTCYDGGAAVNVVN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_STAT1_Stanford
(Direct) (Direct)
STAT1
M08014_2.00
Homo sapiens
YTTCCYRGAAR

YTTCYRGGAAR
ChIP-seq
Gerstein et al.(2012)
K562_STAT1_Stanford
(Direct) (Direct)
STAT1
M08171_2.00
Homo sapiens
HTTCCYRGAAV

BTTCYRGGAAD
ChIP-seq
Mathelier et al.(2014)
MA0137.3
(Direct) (Direct)
STAT1
M08229_2.00
Homo sapiens
NTTCYNRGAA

TTCYNRGAAN
ChIP-seq
Contrino et al.(2012)
Mv124
(Direct) (Direct)
STAT1
M08230_2.00
Homo sapiens
RGTTTCRBTT

AAVYGAAACY
ChIP-seq
Contrino et al.(2012)
Mv125
(Direct) (Direct)
STAT1
M09411_2.00
Homo sapiens
HBHNYTTCCNRGAARHSHN

NDSDYTTCYNGGAARNDVD
Misc
Kulakovskiy et al.(2013)
STAT1_HUMAN.H11MO.0.A
(Direct) (Direct)
STAT1
M09642_2.00
Homo sapiens
NHTTCYNRGAADNN

NNHTTCYNRGAADN
Misc
Heinz et al.(2010)
HelaS3-STAT1_GSE12782
(Direct) (Direct)
STAT1
M11348_2.00
Homo sapiens
NSNYAHTTCCSGGAADBBNHV

BDNVVHTTCCSGGAADTRNSN
Transfac
Matys et al.(2006)
V$STAT1_01
(Direct) (Direct)
STAT1
M11349_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_02
(Direct) (Direct)
STAT1
M11350_2.00
Homo sapiens
VNHTTMBN

NVKAADNB
Transfac
Matys et al.(2006)
V$STAT1_03
(Direct) (Direct)
STAT1
M11351_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_05
(Direct) (Direct)
STAT1
M11352_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_07
(Direct) (Direct)
STAT1
M11353_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_Q4
(Direct) (Direct)
STAT1
M11354_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Stat1
M09422_2.00
Mus musculus
HNDBYNTNDBTTTCHNTTYYYY

RRRRAANDGAAAVHNANRVHND
Misc
Kulakovskiy et al.(2013)
STAT1_MOUSE.H11MO.0.A
0.945 0.945
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000354394 STAT 317 566
ENSP00000376136 STAT 317 566
ENSP00000376137 STAT 319 568
ENSP00000386244 STAT 317 566

Links

Other STAT family TFs
Other Homo sapiens TFs

44 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
estExt_fgenesh3_kg.C_60236 Neurospora discreta estExt_fgenesh3_kg.C_60236 I 0.000
NCU04058 Neurospora crassa NCU04058 D 0.000
NEUTE1DRAFT_124684 Neurospora tetrasperma NEUTE1DRAFT_124684 I 0.000