STAT4 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000138378 T337446_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT4
M09413_2.00
Homo sapiens
YTTCYBDKMAN

NTKMHVRGAAR
Misc
Kulakovskiy et al.(2013)
STAT4_HUMAN.H11MO.0.A
(Direct) (Direct)
STAT4
M11361_2.00
Homo sapiens
BNHTTCNN

NNGAADNV
Transfac
Matys et al.(2006)
V$STAT4_01
(Direct) (Direct)
STAT4
M11362_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT4_Q4
(Direct) (Direct)
STAT4
M11363_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT4_Q5
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Stat4
M08174_2.00
Mus musculus
NNNYTTCYYRGAAV

BTTCYRRGAARNNN
ChIP-seq
Mathelier et al.(2014)
MA0518.1
0.936 0.936
Stat4
M09424_2.00
Mus musculus
YTTCYHDKMA

TKMHDRGAAR
Misc
Kulakovskiy et al.(2013)
STAT4_MOUSE.H11MO.0.A
0.936 0.936
Stat4
M09646_2.00
Mus musculus
NYTTCCNGGAAR

YTTCCNGGAARN
Misc
Heinz et al.(2010)
CD4-Stat4_GSE22104
0.936 0.936
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000351255 STAT 316 562
ENSP00000376134 STAT 316 562

Links

Other STAT family TFs
Other Homo sapiens TFs

35 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Aan_R010750 Calypte anna Aan_R010750 I 0.000
Aan_R014790 Calypte anna Aan_R014790 N 0.000
Afo_R009725 Aptenodytes forsteri Afo_R009725 N 0.000
Afo_R010549 Aptenodytes forsteri Afo_R010549 I 0.000
Alligator_sinensis_CCG012901.1 Alligator sinensis Alligator_sinensis_CCG012901.1 I 0.000
Brh_R007745 Buceros rhinoceros Brh_R007745 I 0.000
Cmyd_10008461 Chelonia mydas Cmyd_10008461 I 0.000
MYRFL Anolis carolinensis ENSACAG00000004738 N 0.000
MYRF Anolis carolinensis ENSACAG00000017691 I 0.000
ENSAMEG00000011926 Ailuropoda melanoleuca ENSAMEG00000011926 N 0.000
ENSAMEG00000016669 Ailuropoda melanoleuca ENSAMEG00000016669 I 0.000
ENSAMXG00000015793 Astyanax mexicanus ENSAMXG00000015793 I 0.000
ENSAMXG00000021027 Astyanax mexicanus ENSAMXG00000021027 N 0.000
ENSAPLG00000006054 Anas platyrhynchos ENSAPLG00000006054 I 0.000
ENSAPLG00000012837 Anas platyrhynchos ENSAPLG00000012837 N 0.000
MYRF Bos taurus ENSBTAG00000006990 I 0.000
MYRFL Bos taurus ENSBTAG00000014829 N 0.000
ENSBTAP00000009187-D1 Bos grunniens ENSBTAP00000009187-D1 I 0.000
ENSBTAP00000019581-D1 Bos grunniens ENSBTAP00000019581-D1 N 0.000
MYRF Canis familiaris ENSCAFG00000016062 I 0.000
MYRF Callithrix jacchus ENSCJAG00000019218 I 0.000
ENSCJAG00000036263 Callithrix jacchus ENSCJAG00000036263 N 0.000
MYRF Cavia porcellus ENSCPOG00000013543 I 0.000
MYRFL Cavia porcellus ENSCPOG00000013850 N 0.000
ENSCSAG00000006452 Chlorocebus sabaeus ENSCSAG00000006452 I 0.000
myrf Danio rerio ENSDARG00000078676 D 0.000
CABZ01077402.1 Danio rerio ENSDARG00000101645 N 0.000
MYRF Dasypus novemcinctus ENSDNOG00000005294 I 0.000
MYRFL Dasypus novemcinctus ENSDNOG00000044488 N 0.000
Myrf Dipodomys ordii ENSDORG00000002029 I 0.000
MYRF Equus caballus ENSECAG00000021799 I 0.000
ENSFALG00000010237 Ficedula albicollis ENSFALG00000010237 N 0.000
ENSFALG00000011806 Ficedula albicollis ENSFALG00000011806 I 0.000
MYRF Felis catus ENSFCAG00000013683 I 0.000
MYRFL Felis catus ENSFCAG00000031998 N 0.000
MYRF Homo sapiens ENSG00000124920 D 0.000
MYRFL Homo sapiens ENSG00000166268 N 0.000
myrf Gasterosteus aculeatus ENSGACG00000005416 I 0.000
MYRFL Gallus gallus ENSGALG00000019352 N 0.000
MYRF Gorilla gorilla ENSGGOG00000012529 I 0.000
ENSGMOG00000017696 Gadus morhua ENSGMOG00000017696 I 0.000
ENSLACG00000016455 Latimeria chalumnae ENSLACG00000016455 I 0.000
MYRFL Loxodonta africana ENSLAFG00000001286 N 0.000
ENSLOCG00000016212 Lepisosteus oculatus ENSLOCG00000016212 N 0.000
ENSMEUG00000004200 Macropus eugenii ENSMEUG00000004200 I 0.000
MYRF Meleagris gallopavo ENSMGAG00000004733 I 0.000
MYRFL Meleagris gallopavo ENSMGAG00000010606 N 0.000
MYRFL Myotis lucifugus ENSMLUG00000009508 N 0.000
MYRF Myotis lucifugus ENSMLUG00000010326 I 0.000
ENSMMUG00000006501 Macaca mulatta ENSMMUG00000006501 I 0.000
MYRF Macaca mulatta ENSMMUG00000006655 I 0.000
ENSMMUP00000039187 Macaca fascicularis ENSMMUP00000039187 N 0.000
MYRFL Monodelphis domestica ENSMODG00000020385 N 0.000
ENSMPUG00000014126 Mustela putorius furo ENSMPUG00000014126 I 0.000
ENSMPUG00000017495 Mustela putorius furo ENSMPUG00000017495 N 0.000
Myrfl Mus musculus ENSMUSG00000034057 N 0.000
Myrf Mus musculus ENSMUSG00000036098 D 0.000
ENSNLEG00000003069 Nomascus leucogenys ENSNLEG00000003069 I 0.000
MYRFL Ornithorhynchus anatinus ENSOANG00000005958 N 0.000
ENSOARG00000013482 Ovis aries ENSOARG00000013482 I 0.000
ENSOARG00000020232 Ovis aries ENSOARG00000020232 I 0.000
MYRFL Oryctolagus cuniculus ENSOCUG00000002982 N 0.000
MYRF Oryctolagus cuniculus ENSOCUG00000003269 I 0.000
MYRF Otolemur garnettii ENSOGAG00000010786 I 0.000
MYRFL Otolemur garnettii ENSOGAG00000028145 N 0.000
ENSONIG00000015523 Oreochromis niloticus ENSONIG00000015523 I 0.000
MYRF Oryzias latipes ENSORLG00000006459 I 0.000
ENSP00000278836 Macaca fascicularis ENSP00000278836 I 0.000
ENSPANG00000013413 Papio anubis ENSPANG00000013413 I 0.000
MYRF Procavia capensis ENSPCAG00000017079 I 0.000
ENSPFOG00000011050 Poecilia formosa ENSPFOG00000011050 I 0.000
ENSPPYG00000003180 Pongo abelii ENSPPYG00000003180 I 0.000
ENSPSIG00000015590 Pelodiscus sinensis ENSPSIG00000015590 I 0.000
MYRF Pan troglodytes ENSPTRG00000003749 I 0.000
MYRF Pteropus vampyrus ENSPVAG00000012342 I 0.000
Myrfl Rattus norvegicus ENSRNOG00000021833 N 0.000
Myrf Rattus norvegicus ENSRNOG00000028274 I 0.000
ENSSHAG00000002443 Sarcophilus harrisii ENSSHAG00000002443 I 0.000
MYRF Sus scrofa ENSSSCG00000013078 I 0.000
ENSSTOG00000000529 Ictidomys tridecemlineatus ENSSTOG00000000529 I 0.000
ENSSTOG00000020113 Ictidomys tridecemlineatus ENSSTOG00000020113 N 0.000
ENSTGUG00000006600 Taeniopygia guttata ENSTGUG00000006600 I 0.000
MYRF Tetraodon nigroviridis ENSTNIG00000016074 I 0.000
MYRF Takifugu rubripes ENSTRUG00000005197 I 0.000
ENSXMAG00000003748 Xiphophorus maculatus ENSXMAG00000003748 I 0.000
Gfo_R011942 Geospiza fortis Gfo_R011942 I 0.000
Ocbimv22003657m.g Octopus bimaculoides Ocbimv22003657m.g N 0.000
Ogr07579 Ophisaurus gracilis Ogr07579 N 0.000
Pvit_15884 Pogona vitticeps Pvit_15884 I 0.000
Sakowv30007714m.g Saccoglossus kowalevskii Sakowv30007714m.g N 0.000
Tal_R006175 Tyto alba Tal_R006175 I 0.000
Tal_R011346 Tyto alba Tal_R011346 N 0.000
myrf Xenopus tropicalis XB-GENE-1020968 I 0.000
myrf.L Xenopus laevis XB-GENE-1020972 I 0.000