STAT6 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000166888 T337447_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT6
M09414_2.00
Homo sapiens
BTTCYDSDGAA

TTCHSHRGAAV
Misc
Kulakovskiy et al.(2013)
STAT6_HUMAN.H11MO.0.B
(Direct) (Direct)
STAT6
M11364_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT6_01
(Direct) (Direct)
STAT6
M11365_2.00
Homo sapiens
NNYTTCYY

RRGAARNN
Transfac
Matys et al.(2006)
V$STAT6_02
(Direct) (Direct)
STAT6
M11366_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT6_Q4
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Stat6
M08173_2.00
Mus musculus
NNBTTCYWVRGAANN

NNTTCYBWRGAAVNN
ChIP-seq
Mathelier et al.(2014)
MA0520.1
0.965 0.965
Stat6
M09418_2.00
Mus musculus
BDBTTCHBDRGAAV

BTTCYHVDGAAVHV
Misc
Kulakovskiy et al.(2013)
STAT6_MOUSE.H11MO.0.A
0.965 0.965
Stat6
M09644_2.00
Mus musculus
TTCCNNAGAA

TTCTNNGGAA
Misc
Heinz et al.(2010)
Macrophage-Stat6_GSE38377
0.939 0.939
Stat6
M09643_2.00
Mus musculus
NNTTCYNNRGAA

TTCYNNRGAANN
Misc
Heinz et al.(2010)
CD4-Stat6_GSE22104
0.939 0.939
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000300134 STAT 6 127
ENSP00000300134 STAT 273 526
ENSP00000401486 STAT 6 127
ENSP00000401486 STAT 273 526
ENSP00000438451 STAT 6 127
ENSP00000438451 STAT 273 526
ENSP00000444530 STAT 163 416
ENSP00000445409 STAT 163 416
ENSP00000450921 STAT 1 92
ENSP00000451546 STAT 2 245
ENSP00000451742 STAT 6 127
ENSP00000451742 STAT 273 526

Links

Other STAT family TFs
Other Homo sapiens TFs

49 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSCSAG00000004973 Chlorocebus sabaeus ENSCSAG00000004973 I 1.000
ENSP00000300134-D1 Bos grunniens ENSP00000300134-D1 I 1.000
STAT6 Canis familiaris ENSCAFG00000000163 I 1.000
ENSPPYG00000004680 Pongo abelii ENSPPYG00000004680 I 0.996
ENSNLEG00000017396 Nomascus leucogenys ENSNLEG00000017396 I 0.996
STAT6 Callithrix jacchus ENSCJAG00000010327 I 0.992
STAT6 Microcebus murinus ENSMICG00000009087 I 0.988
STAT6 Equus caballus ENSECAG00000008705 I 0.988
STAT6 Otolemur garnettii ENSOGAG00000005002 I 0.988
STAT6 Felis catus ENSFCAG00000014571 I 0.984
ENSMPUG00000001746 Mustela putorius furo ENSMPUG00000001746 I 0.980
ENSAMEG00000004487 Ailuropoda melanoleuca ENSAMEG00000004487 I 0.980
STAT6 Bos taurus ENSBTAG00000006335 I 0.980
STAT6 Oryctolagus cuniculus ENSOCUG00000007929 I 0.977
ENSSTOG00000013280 Ictidomys tridecemlineatus ENSSTOG00000013280 I 0.976
STAT6 Gorilla gorilla ENSGGOG00000001424 I 0.972
STAT6 Dasypus novemcinctus ENSDNOG00000033099 I 0.971
STAT6 Loxodonta africana ENSLAFG00000005970 I 0.971
STAT6 Tupaia belangeri ENSTBEG00000013664 I 0.967
STAT6 Ochotona princeps ENSOPRG00000013409 I 0.965
STAT6 Procavia capensis ENSPCAG00000009432 I 0.963
STAT6 Tursiops truncatus ENSTTRG00000013064 I 0.963
STAT6 Pan troglodytes ENSPTRG00000005121 I 0.952
ENSSSCG00000026524 Sus scrofa ENSSSCG00000026524 I 0.947
ENSSSCG00000025960 Sus scrofa ENSSSCG00000025960 I 0.947
STAT6 Myotis lucifugus ENSMLUG00000006689 I 0.939
Myotis_brandtii_STAT6_10018366 Myotis brandtii Myotis_brandtii_STAT6_10018366 I 0.939
Stat6 Rattus norvegicus ENSRNOG00000025023 I 0.939
Stat6 Mus musculus ENSMUSG00000002147 D 0.939
STAT6 Monodelphis domestica ENSMODG00000019411 I 0.919
ENSP00000300134 Macaca fascicularis ENSP00000300134 I 0.902
ENSSHAG00000006372 Sarcophilus harrisii ENSSHAG00000006372 I 0.902
ENSPANG00000024919 Papio anubis ENSPANG00000024919 I 0.902
ENSMEUG00000016670 Macropus eugenii ENSMEUG00000016670 I 0.902
STAT6 Macaca mulatta ENSMMUG00000017527 I 0.899
STAT6 Cavia porcellus ENSCPOG00000012941 I 0.857
ENSGALG00000025956 Gallus gallus ENSGALG00000025956 I 0.838
ENSAPLG00000014705 Anas platyrhynchos ENSAPLG00000014705 I 0.837
Afo_R009816 Aptenodytes forsteri Afo_R009816 I 0.837
ENSMGAG00000006798 Meleagris gallopavo ENSMGAG00000006798 I 0.814
ENSOARG00000007588 Ovis aries ENSOARG00000007588 I 0.812
ENSFALG00000000376 Ficedula albicollis ENSFALG00000000376 I 0.802
ENSTGUG00000015716 Taeniopygia guttata ENSTGUG00000015716 I 0.759
Aan_R000713 Calypte anna Aan_R000713 I 0.755
Alligator_sinensis_CCG009324.2 Alligator sinensis Alligator_sinensis_CCG009324.2 I 0.749
Gfo_R015302 Geospiza fortis Gfo_R015302 I 0.747
STAT6 Anolis carolinensis ENSACAG00000009680 I 0.744
Cmyd_10002722 Chelonia mydas Cmyd_10002722 I 0.723