STAT6 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000166888 T337447_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
STAT6
M09414_2.00		 Homo sapiens
BTTCYDSDGAA
TTCHSHRGAAV		 Misc
Kulakovskiy et al.(2013)
STAT6_HUMAN.H11MO.0.B		 (Direct) (Direct)
STAT6
M11364_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$STAT6_01		 (Direct) (Direct)
STAT6
M11365_2.00		 Homo sapiens
NNYTTCYY
RRGAARNN		 Transfac
Matys et al.(2006)
V$STAT6_02		 (Direct) (Direct)
STAT6
M11366_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$STAT6_Q4		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Stat6
M08173_2.00 		Mus musculus
NNBTTCYWVRGAANN
NNTTCYBWRGAAVNN		 ChIP-seq
Mathelier et al.(2014)
MA0520.1 		0.965 0.965
Stat6
M09418_2.00 		Mus musculus
BDBTTCHBDRGAAV
BTTCYHVDGAAVHV		 Misc
Kulakovskiy et al.(2013)
STAT6_MOUSE.H11MO.0.A 		0.965 0.965
Stat6
M09644_2.00 		Mus musculus
TTCCNNAGAA
TTCTNNGGAA		 Misc
Heinz et al.(2010)
Macrophage-Stat6_GSE38377 		0.939 0.939
Stat6
M09643_2.00 		Mus musculus
NNTTCYNNRGAA
TTCYNNRGAANN		 Misc
Heinz et al.(2010)
CD4-Stat6_GSE22104 		0.939 0.939
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000300134 STAT 6 127
ENSP00000300134 STAT 273 526
ENSP00000401486 STAT 6 127
ENSP00000401486 STAT 273 526
ENSP00000438451 STAT 6 127
ENSP00000438451 STAT 273 526
ENSP00000444530 STAT 163 416
ENSP00000445409 STAT 163 416
ENSP00000450921 STAT 1 92
ENSP00000451546 STAT 2 245
ENSP00000451742 STAT 6 127
ENSP00000451742 STAT 273 526

Links

Other STAT family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

49 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action