STAT3 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000168610 T337448_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT3
M08015_2.00
Homo sapiens
YDTTTMYYRGAARHSABVDB

VHBVTSDYTTCYRRKAAAHR
ChIP-seq
Gerstein et al.(2012)
GM12878_STAT3_Stanford
(Direct) (Direct)
STAT3
M08016_2.00
Homo sapiens
NNNTTCCHRKAAN

NTTMYDGGAANNN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_STAT3_Stanford
(Direct) (Direct)
STAT3
M08017_2.00
Homo sapiens
NNHTTCCYRKMANNN

NNNTKMYRGGAADNN
ChIP-seq
Gerstein et al.(2012)
MCF10A-Er-Src_STAT3_Harvard#Weissman
(Direct) (Direct)
STAT3
M08018_2.00
Homo sapiens
NNHTTCCYRKMANNN

NNNTKMYRGGAADNN
ChIP-seq
Gerstein et al.(2012)
MCF10A-Er-Src_STAT3_Stanford
(Direct) (Direct)
STAT3
M08172_2.00
Homo sapiens
HTTCCHRGMAV

BTKCYDGGAAD
ChIP-seq
Mathelier et al.(2014)
MA0144.2
(Direct) (Direct)
STAT3
M09415_2.00
Homo sapiens
NNYTTCCMRGAA

TTCYKGGAARNN
Misc
Kulakovskiy et al.(2013)
STAT3_HUMAN.H11MO.0.A
(Direct) (Direct)
STAT3
M11367_2.00
Homo sapiens
NBBBATTTCCSGGAARTGNNN

NNNCAYTTCCSGGAAATVVVN
Transfac
Matys et al.(2006)
V$STAT3_01
(Direct) (Direct)
STAT3
M11368_2.00
Homo sapiens
NNNTTCCN

NGGAANNN
Transfac
Matys et al.(2006)
V$STAT3_02
(Direct) (Direct)
STAT3
M11369_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT3_03
(Direct) (Direct)
STAT3
M11370_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT3_Q4
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Stat3
M08043_2.00
Mus musculus
BTTCCYRGMAD

HTKCYRGGAAV
ChIP-seq
Chen et al.(2011)
SRP000217_Stat3
1.000 1.000
Stat3
M09419_2.00
Mus musculus
NNYTTMCHRKMA

TKMYDGKAARNN
Misc
Kulakovskiy et al.(2013)
STAT3_MOUSE.H11MO.0.A
1.000 1.000
Stat3
M09645_2.00
Mus musculus
NNBTTCCNGGAAVN

NBTTCCNGGAAVNN
Misc
Heinz et al.(2010)
CD4-Stat3_GSE19198
1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000264657 STAT 321 573
ENSP00000373923 STAT 223 475
ENSP00000384943 STAT 321 573
ENSP00000467000 STAT 321 573
ENSP00000467985 STAT 321 573

Links

Other STAT family TFs
Other Homo sapiens TFs

66 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
STAT3 Otolemur garnettii ENSOGAG00000001517 I 1.000
ENSOARG00000001511 Ovis aries ENSOARG00000001511 I 1.000
ENSPANG00000021451 Papio anubis ENSPANG00000021451 I 1.000
STAT3 Pan troglodytes ENSPTRG00000009200 I 1.000
Stat3 Rattus norvegicus ENSRNOG00000019742 I 1.000
ENSNLEG00000011454 Nomascus leucogenys ENSNLEG00000011454 I 1.000
Stat3 Mus musculus ENSMUSG00000004040 D 1.000
STAT3 Myotis lucifugus ENSMLUG00000017449 I 1.000
STAT3 Macaca mulatta ENSMMUG00000010707 I 1.000
STAT3 Monodelphis domestica ENSMODG00000028212 I 1.000
ENSMPUG00000010509 Mustela putorius furo ENSMPUG00000010509 I 1.000
STAT3 Sorex araneus ENSSARG00000014231 I 1.000
ENSSTOG00000006741 Ictidomys tridecemlineatus ENSSTOG00000006741 I 1.000
ENSMMUP00000014032 Macaca fascicularis ENSMMUP00000014032 I 1.000
Gfo_R009044 Geospiza fortis Gfo_R009044 I 1.000
Myotis_brandtii_STAT3_10015327 Myotis brandtii Myotis_brandtii_STAT3_10015327 I 1.000
stat3.1 Xenopus tropicalis XB-GENE-481047 I 1.000
ENSBTAP00000028687-D1 Bos grunniens ENSBTAP00000028687-D1 I 1.000
Cmyd_10007079 Chelonia mydas Cmyd_10007079 I 1.000
STAT3 Tursiops truncatus ENSTTRG00000007163 I 1.000
Aan_R006196 Calypte anna Aan_R006196 I 1.000
Afo_R011287 Aptenodytes forsteri Afo_R011287 I 1.000
Alligator_sinensis_CCG021133.1 Alligator sinensis Alligator_sinensis_CCG021133.1 I 1.000
STAT3 Microcebus murinus ENSMICG00000012015 I 1.000
STAT3 Oryctolagus cuniculus ENSOCUG00000011034 I 1.000
STAT3 Dasypus novemcinctus ENSDNOG00000001471 I 1.000
STAT3 Gallus gallus ENSGALG00000003267 I 1.000
STAT3 Equus caballus ENSECAG00000016439 I 1.000
STAT3 Meleagris gallopavo ENSMGAG00000003545 I 1.000
STAT3 Felis catus ENSFCAG00000002154 I 1.000
ENSFALG00000000674 Ficedula albicollis ENSFALG00000000674 I 1.000
ENSCSAG00000003215 Chlorocebus sabaeus ENSCSAG00000003215 I 1.000
STAT3 Loxodonta africana ENSLAFG00000014062 I 1.000
ENSAMEG00000006266 Ailuropoda melanoleuca ENSAMEG00000006266 I 1.000
STAT3 Cavia porcellus ENSCPOG00000007939 I 1.000
STAT3 Bos taurus ENSBTAG00000021523 I 1.000
stat3.1.L Xenopus laevis XB-GENE-865436 I 0.996
STAT3 Canis familiaris ENSCAFG00000015213 I 0.996
ENSSHAG00000014833 Sarcophilus harrisii ENSSHAG00000014833 I 0.996
STAT3 Taeniopygia guttata ENSTGUG00000002600 I 0.996
STAT3 Sus scrofa ENSSSCG00000017403 I 0.996
ENSMEUG00000006663 Macropus eugenii ENSMEUG00000006663 I 0.996
STAT3 Anolis carolinensis ENSACAG00000017940 I 0.992
Pvit_13933 Pogona vitticeps Pvit_13933 I 0.992
stat3.2.L Xenopus laevis XB-GENE-1020979 I 0.983
stat3.2 Xenopus tropicalis XB-GENE-1020976 I 0.983
ENSLOCG00000012514 Lepisosteus oculatus ENSLOCG00000012514 I 0.975
ENSLACG00000012019 Latimeria chalumnae ENSLACG00000012019 I 0.975
stat3 Danio rerio ENSDARG00000022712 I 0.971
ENSXMAG00000008972 Xiphophorus maculatus ENSXMAG00000008972 I 0.971
ENSPFOG00000012687 Poecilia formosa ENSPFOG00000012687 I 0.971
ENSPFOG00000012990 Poecilia formosa ENSPFOG00000012990 I 0.971
ENSGMOG00000014955 Gadus morhua ENSGMOG00000014955 I 0.966
stat3 Gasterosteus aculeatus ENSGACG00000008607 I 0.966
stat3 Oryzias latipes ENSORLG00000004061 I 0.966
ENSONIG00000001148 Oreochromis niloticus ENSONIG00000001148 I 0.966
stat3 Takifugu rubripes ENSTRUG00000015348 I 0.958
Ogr09154 Ophisaurus gracilis Ogr09154 I 0.933
STAT3 Gorilla gorilla ENSGGOG00000017110 I 0.916
ENSPPYG00000008392 Pongo abelii ENSPPYG00000008392 I 0.916
Brh_R003680 Buceros rhinoceros Brh_R003680 I 0.912
ENSAMXG00000000502 Astyanax mexicanus ENSAMXG00000000502 I 0.840
ENSAPLG00000007739 Anas platyrhynchos ENSAPLG00000007739 I 0.832
STAT3 Callithrix jacchus ENSCJAG00000000409 I 0.756
ENSPMAG00000002770 Petromyzon marinus ENSPMAG00000002770 I 0.740