STAT2 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000170581 T337449_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT2
M08019_2.00
Homo sapiens
NTNRGTTTCDNTTYC

GRAANHGAAACYNAN
ChIP-seq
Gerstein et al.(2012)
K562_STAT2_Stanford
(Direct) (Direct)
STAT2
M09416_2.00
Homo sapiens
NYYTHASTTTCNNTTYYYY

RRRRAANNGAAASTDARRN
Misc
Kulakovskiy et al.(2013)
STAT2_HUMAN.H11MO.0.A
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Stat2
M09423_2.00
Mus musculus
NYYTHASTTTCNNTTYYYY

RRRRAANNGAAASTDARRN
Misc
Kulakovskiy et al.(2013)
STAT2_MOUSE.H11MO.0.A
0.790 0.790
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000315768 STAT 316 565
ENSP00000387354 STAT 312 446
ENSP00000450751 STAT 312 561

Links

Other STAT family TFs
Other Homo sapiens TFs

33 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSCSAG00000005161 Chlorocebus sabaeus ENSCSAG00000005161 I 1.000
ENSPANG00000012539 Papio anubis ENSPANG00000012539 I 0.996
STAT2 Gorilla gorilla ENSGGOG00000006127 I 0.996
STAT2 Pan troglodytes ENSPTRG00000005095 I 0.996
ENSP00000315768 Macaca fascicularis ENSP00000315768 I 0.996
STAT2 Macaca mulatta ENSMMUG00000000803 I 0.996
ENSNLEG00000017494 Nomascus leucogenys ENSNLEG00000017494 I 0.991
ENSCJAG00000011101 Callithrix jacchus ENSCJAG00000011101 I 0.969
STAT2 Equus caballus ENSECAG00000022326 I 0.926
ENSMPUG00000001431 Mustela putorius furo ENSMPUG00000001431 I 0.908
Myotis_brandtii_STAT2_10009187 Myotis brandtii Myotis_brandtii_STAT2_10009187 I 0.905
STAT2 Felis catus ENSFCAG00000012023 I 0.900
ENSCAFG00000000121 Canis familiaris ENSCAFG00000000121 I 0.891
ENSAMEG00000003886 Ailuropoda melanoleuca ENSAMEG00000003886 I 0.882
STAT2 Myotis lucifugus ENSMLUG00000006785 I 0.882
STAT2 Otolemur garnettii ENSOGAG00000001538 I 0.878
STAT2 Loxodonta africana ENSLAFG00000014890 I 0.873
ENSBTAP00000005749-D1 Bos grunniens ENSBTAP00000005749-D1 I 0.871
ENSOARG00000009154 Ovis aries ENSOARG00000009154 I 0.859
STAT2 Bos taurus ENSBTAG00000004380 I 0.856
STAT2 Cavia porcellus ENSCPOG00000014930 I 0.838
Stat2 Dipodomys ordii ENSDORG00000012958 I 0.838
ENSSTOG00000015985 Ictidomys tridecemlineatus ENSSTOG00000015985 I 0.828
ENSCAFG00000017707 Canis familiaris ENSCAFG00000017707 I 0.821
STAT2 Procavia capensis ENSPCAG00000007855 I 0.811
Stat2 Rattus norvegicus ENSRNOG00000031081 I 0.808
STAT2 Dasypus novemcinctus ENSDNOG00000011002 I 0.795
Stat2 Mus musculus ENSMUSG00000040033 D 0.790
STAT2 Echinops telfairi ENSETEG00000012048 I 0.785
STAT2 Pteropus vampyrus ENSPVAG00000007596 I 0.772
ENSSHAG00000000508 Sarcophilus harrisii ENSSHAG00000000508 I 0.725
STAT2 Choloepus hoffmanni ENSCHOG00000012984 I 0.718