STAT2 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000170581 T337449_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
STAT2
M08019_2.00		 Homo sapiens
NTNRGTTTCDNTTYC
GRAANHGAAACYNAN		 ChIP-seq
Gerstein et al.(2012)
K562_STAT2_Stanford		 (Direct) (Direct)
STAT2
M09416_2.00		 Homo sapiens
NYYTHASTTTCNNTTYYYY
RRRRAANNGAAASTDARRN		 Misc
Kulakovskiy et al.(2013)
STAT2_HUMAN.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Stat2
M09423_2.00 		Mus musculus
NYYTHASTTTCNNTTYYYY
RRRRAANNGAAASTDARRN		 Misc
Kulakovskiy et al.(2013)
STAT2_MOUSE.H11MO.0.A 		0.790 0.790
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000315768 STAT 316 565
ENSP00000387354 STAT 312 446
ENSP00000450751 STAT 312 561

Links

Other STAT family TFs
Other Homo sapiens TFs

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33 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action