Stat6 (Mus musculus)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSMUSG00000002147 T337541_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interleukin-4-mediated signaling pathway and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; alimentary system; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Stat6
M08173_2.00		 Mus musculus
NNBTTCYWVRGAANN
NNTTCYBWRGAAVNN		 ChIP-seq
Mathelier et al.(2014)
MA0520.1		 (Direct) (Direct)
Stat6
M09418_2.00		 Mus musculus
BDBTTCHBDRGAAV
BTTCYHVDGAAVHV		 Misc
Kulakovskiy et al.(2013)
STAT6_MOUSE.H11MO.0.A		 (Direct) (Direct)
Stat6
M09643_2.00		 Mus musculus
NNTTCYNNRGAA
TTCYNNRGAANN		 Misc
Heinz et al.(2010)
CD4-Stat6_GSE22104		 (Direct) (Direct)
Stat6
M09644_2.00		 Mus musculus
TTCCNNAGAA
TTCTNNGGAA		 Misc
Heinz et al.(2010)
Macrophage-Stat6_GSE38377		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000089708 STAT 273 526

Links

Other STAT family TFs
Other Mus musculus TFs

Invalid Input OrderBy

39 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action