Stat5b (Mus musculus)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSMUSG00000020919 T337544_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Stat5b
M09421_2.00		 Mus musculus
NNTTCYMRGAAN
NTTCYKRGAANN		 Misc
Kulakovskiy et al.(2013)
STA5B_MOUSE.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
STAT5B
M09417_2.00 		Homo sapiens
NNTTCYMRGAAN
NTTCYKRGAANN		 Misc
Kulakovskiy et al.(2013)
STA5B_HUMAN.H11MO.0.A 		0.979 0.979
STAT5B
M11371_2.00 		Homo sapiens
NDWTTCYNGGAAWHN
NDWTTCCNRGAAWHN		 Transfac
Matys et al.(2006)
V$STAT5B_01 		0.979 0.979
Stat5a
M09420_2.00 		Mus musculus
TTCYMRGAAN
NTTCYKRGAA		 Misc
Kulakovskiy et al.(2013)
STA5A_MOUSE.H11MO.0.A 		0.971 0.971
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000004143 STAT 332 582
ENSMUSP00000102981 STAT 332 582

Links

Other STAT family TFs
Other Mus musculus TFs

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102 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action