ENSP00000300134 (Macaca fascicularis)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF02864 (STAT_bind) IPR013801 ENSP00000300134 T337830_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT6
M09414_2.00
Homo sapiens
BTTCYDSDGAA

TTCHSHRGAAV
Misc
Kulakovskiy et al.(2013)
STAT6_HUMAN.H11MO.0.B
0.875 0.875
STAT6
M11364_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT6_01
0.875 0.875
STAT6
M11365_2.00
Homo sapiens
NNYTTCYY

RRGAARNN
Transfac
Matys et al.(2006)
V$STAT6_02
0.875 0.875
STAT6
M11366_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT6_Q4
0.875 0.875
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000300134 STAT 6 130
ENSP00000300134 STAT 273 526

Links

Other STAT family TFs
Other Macaca fascicularis TFs

8 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSPANG00000024919 Papio anubis ENSPANG00000024919 I 0.997
STAT6 Macaca mulatta ENSMMUG00000017527 I 0.995
STAT6 Callithrix jacchus ENSCJAG00000010327 I 0.973
STAT6 Cavia porcellus ENSCPOG00000012941 I 0.925
STAT6 Gorilla gorilla ENSGGOG00000001424 I 0.903
STAT6 Homo sapiens ENSG00000166888 D 0.902
ENSOARG00000007588 Ovis aries ENSOARG00000007588 I 0.833
STAT6 Pan troglodytes ENSPTRG00000005121 I 0.828