ENSP00000315768 (Macaca fascicularis)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF02864 (STAT_bind) IPR013801 ENSP00000315768 T337831_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT2
M08019_2.00
Homo sapiens
NTNRGTTTCDNTTYC

GRAANHGAAACYNAN
ChIP-seq
Gerstein et al.(2012)
K562_STAT2_Stanford
0.996 0.996
STAT2
M09416_2.00
Homo sapiens
NYYTHASTTTCNNTTYYYY

RRRRAANNGAAASTDARRN
Misc
Kulakovskiy et al.(2013)
STAT2_HUMAN.H11MO.0.A
0.996 0.996
Stat2
M09423_2.00
Mus musculus
NYYTHASTTTCNNTTYYYY

RRRRAANNGAAASTDARRN
Misc
Kulakovskiy et al.(2013)
STAT2_MOUSE.H11MO.0.A
0.786 0.786
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000315768 STAT 316 565

Links

Other STAT family TFs
Other Macaca fascicularis TFs

32 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
STAT2 Macaca mulatta ENSMMUG00000000803 I 1.000
STAT2 Homo sapiens ENSG00000170581 D 0.996
ENSPANG00000012539 Papio anubis ENSPANG00000012539 I 0.996
ENSCSAG00000005161 Chlorocebus sabaeus ENSCSAG00000005161 I 0.996
STAT2 Pan troglodytes ENSPTRG00000005095 I 0.991
STAT2 Gorilla gorilla ENSGGOG00000006127 I 0.991
ENSNLEG00000017494 Nomascus leucogenys ENSNLEG00000017494 I 0.987
ENSCJAG00000011101 Callithrix jacchus ENSCJAG00000011101 I 0.965
STAT2 Equus caballus ENSECAG00000022326 I 0.921
ENSMPUG00000001431 Mustela putorius furo ENSMPUG00000001431 I 0.904
Myotis_brandtii_STAT2_10009187 Myotis brandtii Myotis_brandtii_STAT2_10009187 I 0.895
STAT2 Felis catus ENSFCAG00000012023 I 0.895
ENSCAFG00000000121 Canis familiaris ENSCAFG00000000121 I 0.886
STAT2 Myotis lucifugus ENSMLUG00000006785 I 0.878
ENSAMEG00000003886 Ailuropoda melanoleuca ENSAMEG00000003886 I 0.878
STAT2 Otolemur garnettii ENSOGAG00000001538 I 0.873
STAT2 Loxodonta africana ENSLAFG00000014890 I 0.869
ENSBTAP00000005749-D1 Bos grunniens ENSBTAP00000005749-D1 I 0.865
ENSOARG00000009154 Ovis aries ENSOARG00000009154 I 0.855
STAT2 Bos taurus ENSBTAG00000004380 I 0.852
Stat2 Dipodomys ordii ENSDORG00000012958 I 0.834
STAT2 Cavia porcellus ENSCPOG00000014930 I 0.833
ENSCAFG00000017707 Canis familiaris ENSCAFG00000017707 I 0.817
ENSSTOG00000015985 Ictidomys tridecemlineatus ENSSTOG00000015985 I 0.814
STAT2 Procavia capensis ENSPCAG00000007855 I 0.807
Stat2 Rattus norvegicus ENSRNOG00000031081 I 0.803
STAT2 Dasypus novemcinctus ENSDNOG00000011002 I 0.790
Stat2 Mus musculus ENSMUSG00000040033 D 0.786
STAT2 Echinops telfairi ENSETEG00000012048 I 0.785
STAT2 Pteropus vampyrus ENSPVAG00000007596 I 0.767
ENSSHAG00000000508 Sarcophilus harrisii ENSSHAG00000000508 I 0.721
STAT2 Choloepus hoffmanni ENSCHOG00000012984 I 0.712