tbr1a (Danio rerio)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSDARG00000076259 T339773_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including commitment of neuronal cell to specific neuron type in forebrain; regulation of neuron projection development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in olfactory placode and peripheral olfactory organ. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TBR1 (T-box brain transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbr1
M01028_2.00 		Mus musculus
DTVRCAMNYH
DRNKTGYBAH		 PBM
SebePedros et al.(2013)
pTH2659 		0.835 0.880
TBR1
M03560_2.00 		Homo sapiens
AGGTGTGAAN
NTTCACACCT		 SELEX
Jolma et al.(2013)
TBR1_1 		0.835 0.880
TBR1
M03561_2.00 		Homo sapiens
RAGGTGTGAAH
DTTCACACCTY		 SELEX
Jolma et al.(2013)
TBR1_2 		0.835 0.880
Eomes
M00215_2.00 		Mus musculus
RDGTGYBANN
NNTVRCACHY		 PBM
Badis et al.(2009)
Eomes_0921 		0.816 0.792
EOMES
M03563_2.00 		Homo sapiens
DAGGTGTGAWNNN
NNNWTCACACCTH		 SELEX
Jolma et al.(2013)
EOMES_1 		0.816 0.787
EOMES
M03564_2.00 		Homo sapiens
TVACACNTNNNDRNGTGTGA
TCACACNYHNNNANGTGTBA		 SELEX
Jolma et al.(2013)
EOMES_2 		0.816 0.787
EOMES
M02752_2.00 		Homo sapiens
AGGTGTGAW
WTCACACCT		 SELEX
Jolma et al.(2010)
EOMES_monomer 		0.816 0.787
EOMES
M05807_2.00 		Homo sapiens
DAGGTGTGAN
NTCACACCTH		 SELEX
Yin et al.(2017)
EOMES_eDBD_HT-SELEX 		0.816 0.787
EOMES
M09647_2.00 		Homo sapiens
ARGTGWKAAN
NTTMWCACYT		 Misc
Heinz et al.(2010)
H9-Eomes_GSE26097 		0.816 0.787
EOMES
M05808_2.00 		Homo sapiens
NABGTGYKAH
DTMRCACVTN		 SELEX
Yin et al.(2017)
EOMES_eDBD_Methyl-HT-SELEX 		0.816 0.787
A0A075Q982_PATMI
M00734_2.00 		Patiria miniata
NAGGTGTBAN
NTVACACCTN		 PBM
Cheatle-Jarvela et al.(2014)
PmTbr 		0.788 0.634
SPU_025584
M00733_2.00 		Strongylocentrotus purpuratus
RGGTGTGANN
NNTCACACCY		 PBM
Cheatle-Jarvela et al.(2014)
SpTbr 		0.751 0.607
TBX21
M03546_2.00 		Homo sapiens
GGTGTGAHDTMACACY
RGTGTKAHDTCACACC		 SELEX
Jolma et al.(2013)
TBX21_1 		0.739 0.699
TBX21
M03547_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_2 		0.739 0.699
TBX21
M03548_2.00 		Homo sapiens
TMACACYTNNDAGGTGTGA
TCACACCTHNNARGTGTKA		 SELEX
Jolma et al.(2013)
TBX21_3 		0.739 0.699
TBX21
M03549_2.00 		Homo sapiens
GGTGTGAWATCACACC
GGTGTGATWTCACACC		 SELEX
Jolma et al.(2013)
TBX21_4 		0.739 0.699
TBX21
M03550_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_5 		0.739 0.699
TBX21
M03551_2.00 		Homo sapiens
TSACACCWNMRAGGTGTGA
TCACACCTYKNWGGTGTSA		 SELEX
Jolma et al.(2013)
TBX21_6 		0.739 0.699
TBX21
M05793_2.00 		Homo sapiens
DAGGTGTKAN
NTMACACCTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_HT-SELEX 		0.739 0.699
TBX21
M09425_2.00 		Homo sapiens
NDSDRGSTGWBRN
NYVWCASCYHSHN		 Misc
Kulakovskiy et al.(2013)
TBX21_HUMAN.H11MO.0.A 		0.739 0.699
Tbx21
M09428_2.00 		Mus musculus
DNDDSTGWSDND
HNHSWCASHHNH		 Misc
Kulakovskiy et al.(2013)
TBX21_MOUSE.H11MO.0.A 		0.739 0.699
Tbx21
M09648_2.00 		Mus musculus
ADGTGWSAHN
NDTSWCACHT		 Misc
Heinz et al.(2010)
CD8-Tbet_GSE33802 		0.739 0.699
TBX21
M05794_2.00 		Homo sapiens
DASGTGTKAW
WTMACACSTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_Methyl-HT-SELEX 		0.739 0.699
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000040179 T-box 145 332

Links

Other T-box family TFs
Other Danio rerio TFs

Invalid Input OrderBy

155 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action