TBR1 (Homo sapiens)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSG00000136535 T339893_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
TBR1
M03560_2.00
Homo sapiens
AGGTGTGAAN

NTTCACACCT
SELEX
Jolma et al.(2013)
TBR1_1
(Direct) (Direct)
TBR1
M03561_2.00
Homo sapiens
RAGGTGTGAAH

DTTCACACCTY
SELEX
Jolma et al.(2013)
TBR1_2
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Tbr1
M01028_2.00
Mus musculus
DTVRCAMNYH

DRNKTGYBAH
PBM
SebePedros et al.(2013)
pTH2659
0.530 1.000
Eomes
M00215_2.00
Mus musculus
RDGTGYBANN

NNTVRCACHY
PBM
Badis et al.(2009)
Eomes_0921
0.865 0.874
EOMES
M03563_2.00
Homo sapiens
DAGGTGTGAWNNN

NNNWTCACACCTH
SELEX
Jolma et al.(2013)
EOMES_1
0.865 0.869
EOMES
M03564_2.00
Homo sapiens
TVACACNTNNNDRNGTGTGA

TCACACNYHNNNANGTGTBA
SELEX
Jolma et al.(2013)
EOMES_2
0.865 0.869
EOMES
M02752_2.00
Homo sapiens
AGGTGTGAW

WTCACACCT
SELEX
Jolma et al.(2010)
EOMES_monomer
0.865 0.869
EOMES
M05807_2.00
Homo sapiens
DAGGTGTGAN

NTCACACCTH
SELEX
Yin et al.(2017)
EOMES_eDBD_HT-SELEX
0.865 0.869
EOMES
M09647_2.00
Homo sapiens
ARGTGWKAAN

NTTMWCACYT
Misc
Heinz et al.(2010)
H9-Eomes_GSE26097
0.865 0.869
EOMES
M05808_2.00
Homo sapiens
NABGTGYKAH

DTMRCACVTN
SELEX
Yin et al.(2017)
EOMES_eDBD_Methyl-HT-SELEX
0.865 0.869
A0A075Q982_PATMI
M00734_2.00
Patiria miniata
NAGGTGTBAN

NTVACACCTN
PBM
Cheatle-Jarvela et al.(2014)
PmTbr
0.789 0.645
TBX21
M03546_2.00
Homo sapiens
GGTGTGAHDTMACACY

RGTGTKAHDTCACACC
SELEX
Jolma et al.(2013)
TBX21_1
0.766 0.732
TBX21
M03547_2.00
Homo sapiens
DAGGTGTGAW

WTCACACCTH
SELEX
Jolma et al.(2013)
TBX21_2
0.766 0.732
TBX21
M03548_2.00
Homo sapiens
TMACACYTNNDAGGTGTGA

TCACACCTHNNARGTGTKA
SELEX
Jolma et al.(2013)
TBX21_3
0.766 0.732
TBX21
M03549_2.00
Homo sapiens
GGTGTGAWATCACACC

GGTGTGATWTCACACC
SELEX
Jolma et al.(2013)
TBX21_4
0.766 0.732
TBX21
M03550_2.00
Homo sapiens
DAGGTGTGAW

WTCACACCTH
SELEX
Jolma et al.(2013)
TBX21_5
0.766 0.732
TBX21
M03551_2.00
Homo sapiens
TSACACCWNMRAGGTGTGA

TCACACCTYKNWGGTGTSA
SELEX
Jolma et al.(2013)
TBX21_6
0.766 0.732
TBX21
M05793_2.00
Homo sapiens
DAGGTGTKAN

NTMACACCTH
SELEX
Yin et al.(2017)
TBX21_eDBD_HT-SELEX
0.766 0.732
TBX21
M09425_2.00
Homo sapiens
NDSDRGSTGWBRN

NYVWCASCYHSHN
Misc
Kulakovskiy et al.(2013)
TBX21_HUMAN.H11MO.0.A
0.766 0.732
Tbx21
M09428_2.00
Mus musculus
DNDDSTGWSDND

HNHSWCASHHNH
Misc
Kulakovskiy et al.(2013)
TBX21_MOUSE.H11MO.0.A
0.766 0.732
Tbx21
M09648_2.00
Mus musculus
ADGTGWSAHN

NDTSWCACHT
Misc
Heinz et al.(2010)
CD8-Tbet_GSE33802
0.766 0.732
TBX21
M05794_2.00
Homo sapiens
DASGTGTKAW

WTMACACSTH
SELEX
Yin et al.(2017)
TBX21_eDBD_Methyl-HT-SELEX
0.766 0.732
SPU_025584
M00733_2.00
Strongylocentrotus purpuratus
RGGTGTGANN

NNTCACACCY
PBM
Cheatle-Jarvela et al.(2014)
SpTbr
0.762 0.617
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000374205 T-box 206 393
ENSP00000387023 T-box 1 106
ENSP00000393934 T-box 1 128

Links

Other T-box family TFs
Other Homo sapiens TFs

219 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000012360 Ailuropoda melanoleuca ENSAMEG00000012360 I 0.920
ENSAMEG00000012731 Ailuropoda melanoleuca ENSAMEG00000012731 I 0.865
ENSAMEG00000004661 Ailuropoda melanoleuca ENSAMEG00000004661 I 0.766
Alligator_sinensis_CCG006942.1 Alligator sinensis Alligator_sinensis_CCG006942.1 N 0.779
Alligator_sinensis_CCG014450.1 Alligator sinensis Alligator_sinensis_CCG014450.1 I 0.862
Alligator_sinensis_CCG012002.1 Alligator sinensis Alligator_sinensis_CCG012002.1 I 0.913
ANCCAN_02907 Ancylostoma caninum ANCCAN_02907 N 0.791
ANCCAN_17994 Ancylostoma caninum ANCCAN_17994 N 0.766
ENSACAG00000007044 Anolis carolinensis ENSACAG00000007044 N 0.747
ENSACAG00000011860 Anolis carolinensis ENSACAG00000011860 N 0.920
EOMES Anolis carolinensis ENSACAG00000014201 I 0.873
AATE020165 Anopheles atroparvus AATE020165 N 0.780
AMEM004106 Anopheles merus AMEM004106 N 0.771
ASIS020776 Anopheles sinensis ASIS020776 N 0.737
Afo_R015481 Aptenodytes forsteri Afo_R015481 N 0.757
ENSAMXG00000009990 Astyanax mexicanus ENSAMXG00000009990 I 0.908
ENSAMXG00000012247 Astyanax mexicanus ENSAMXG00000012247 I 0.846
ENSAMXG00000010492 Astyanax mexicanus ENSAMXG00000010492 I 0.873
BGLB008878 Biomphalaria glabrata BGLB008878 N 0.744
ENSBTAP00000018875-D1 Bos grunniens ENSBTAP00000018875-D1 I 0.763
ENSP00000388620-D1 Bos grunniens ENSP00000388620-D1 I 0.825
ENSP00000374205-D1 Bos grunniens ENSP00000374205-D1 I 0.913
EOMES Bos taurus ENSBTAG00000016920 I 0.865
TBR1 Bos taurus ENSBTAG00000021692 I 0.920
TBX21 Bos taurus ENSBTAG00000014199 I 0.763
estExt_fgenesh2_kg.C_1840001 Branchiostoma floridae estExt_fgenesh2_kg.C_1840001 I 0.799
fgenesh2_pg.scaffold_55000054 Branchiostoma floridae fgenesh2_pg.scaffold_55000054 I 0.799
Brh_R005675 Buceros rhinoceros Brh_R005675 N 0.754
Brh_R007719 Buceros rhinoceros Brh_R007719 I 0.843
CJA37253 Caenorhabditis japonica CJA37253 N 0.776
CRE02357 Caenorhabditis remanei CRE02357 N 0.749
TBX21 Callithrix jacchus ENSCJAG00000007796 I 0.758
TBR1 Callithrix jacchus ENSCJAG00000005603 I 0.920
EOMES Callithrix jacchus ENSCJAG00000004263 I 0.860
TBX5 Callithrix jacchus ENSCJAG00000009744 I 0.773
Aan_R005441 Calypte anna Aan_R005441 N 0.774
Aan_R007630 Calypte anna Aan_R007630 N 0.757
Cflo_07689--XP_001122560.1_APIME Camponotus floridanus Cflo_07689--XP_001122560.1_APIME N 0.760
TBR1 Canis familiaris ENSCAFG00000009984 I 0.920
TBX21 Canis familiaris ENSCAFG00000016705 I 0.766
EOMES Canis familiaris ENSCAFG00000005510 I 0.865
CapteG223644 Capitella teleta CapteG223644 I 0.758
EOMES Cavia porcellus ENSCPOG00000004381 I 0.865
ENSCPOG00000005881 Cavia porcellus ENSCPOG00000005881 I 0.920
TBX21 Cavia porcellus ENSCPOG00000026273 I 0.739
Cmyd_10011686 Chelonia mydas Cmyd_10011686 N 0.779
ENSCSAG00000009676 Chlorocebus sabaeus ENSCSAG00000009676 I 0.740
ENSCSAG00000002587 Chlorocebus sabaeus ENSCSAG00000002587 I 0.766
ENSCSAG00000015663 Chlorocebus sabaeus ENSCSAG00000015663 I 0.920
CGI_10020437 Crassostrea gigas CGI_10020437 I 0.734
CpipJ_CPIJ000433 Culex pipiens CpipJ_CPIJ000433 N 0.743
CPIJ000433 Culex quinquefasciatus CPIJ000433 N 0.743
tbr1a Danio rerio ENSDARG00000076259 I 0.835
tbr1b Danio rerio ENSDARG00000004712 I 0.908
tbx21 Danio rerio ENSDARG00000004473 I 0.874
eomesa Danio rerio ENSDARG00000006640 I 0.846
eomesb Danio rerio ENSDARG00000104243 I 0.848
TBR1 Dasypus novemcinctus ENSDNOG00000009816 I 0.920
Tbx21 Dipodomys ordii ENSDORG00000013302 I 0.766
Eomes Dipodomys ordii ENSDORG00000016346 I 0.865
ENSETEG00000009362 Echinops telfairi ENSETEG00000009362 N 0.735
ENSECAG00000011159 Equus caballus ENSECAG00000011159 N 0.803
ENSECAG00000018160 Equus caballus ENSECAG00000018160 N 0.819
EOMES Equus caballus ENSECAG00000021052 I 0.861
ENSECAG00000002502 Equus caballus ENSECAG00000002502 I 0.156
EOMES Erinaceus europaeus ENSEEUG00000005958 I 0.865
TBX21 Felis catus ENSFCAG00000010607 I 0.766
EOMES Felis catus ENSFCAG00000003602 I 0.865
TBR1 Felis catus ENSFCAG00000025073 I 0.917
ENSFALG00000004466 Ficedula albicollis ENSFALG00000004466 I 0.920
ENSFALG00000009181 Ficedula albicollis ENSFALG00000009181 I 0.873
ENSGMOG00000014981 Gadus morhua ENSGMOG00000014981 I 0.897
ENSGMOG00000003675 Gadus morhua ENSGMOG00000003675 I 0.825
ENSGMOG00000002634 Gadus morhua ENSGMOG00000002634 I 0.849
ENSGMOG00000001960 Gadus morhua ENSGMOG00000001960 N 0.816
EOMES Gallus gallus ENSGALG00000027247 I 0.873
eomesb Gasterosteus aculeatus ENSGACG00000006345 I 0.846
tbr1b Gasterosteus aculeatus ENSGACG00000005648 I 0.902
tbx21 Gasterosteus aculeatus ENSGACG00000003829 N 0.826
eomesa Gasterosteus aculeatus ENSGACG00000003160 I 0.849
Gfo_R006963 Geospiza fortis Gfo_R006963 N 0.867
TBR1 Gorilla gorilla ENSGGOG00000015752 I 0.920
EOMES Gorilla gorilla ENSGGOG00000008358 I 0.865
TBX21 Gorilla gorilla ENSGGOG00000002208 I 0.766
HelroG89689 Helobdella robusta HelroG89689 N 0.816
EOMES Homo sapiens ENSG00000163508 D 0.865
TBX21 Homo sapiens ENSG00000073861 D 0.766
ENSSTOG00000020918 Ictidomys tridecemlineatus ENSSTOG00000020918 I 0.865
ENSSTOG00000001626 Ictidomys tridecemlineatus ENSSTOG00000001626 I 0.766
ENSSTOG00000023843 Ictidomys tridecemlineatus ENSSTOG00000023843 I 0.920
ISCW019280 Ixodes scapularis ISCW019280 N 0.788
ENSLACG00000002795 Latimeria chalumnae ENSLACG00000002795 N 0.757
ENSLACG00000016985 Latimeria chalumnae ENSLACG00000016985 I 0.805
ENSLACG00000003893 Latimeria chalumnae ENSLACG00000003893 I 0.918
ENSLOCG00000002398 Lepisosteus oculatus ENSLOCG00000002398 I 0.872
ENSLOCG00000008583 Lepisosteus oculatus ENSLOCG00000008583 I 0.911
ENSLOCG00000013335 Lepisosteus oculatus ENSLOCG00000013335 I 0.881
LotgiG129911 Lottia gigantea LotgiG129911 I 0.766
TBR1 Loxodonta africana ENSLAFG00000011541 I 0.920
EOMES Loxodonta africana ENSLAFG00000004142 I 0.865
ENSP00000177694 Macaca fascicularis ENSP00000177694 I 0.766
ENSP00000388620 Macaca fascicularis ENSP00000388620 I 0.837
ENSP00000374205 Macaca fascicularis ENSP00000374205 I 0.920
TBR1 Macaca mulatta ENSMMUG00000011911 I 0.920
ENSMMUG00000001904 Macaca mulatta ENSMMUG00000001904 I 0.865
TBX21 Macaca mulatta ENSMMUG00000007098 I 0.766
ENSMEUG00000014480 Macropus eugenii ENSMEUG00000014480 I 0.242
ENSMGAG00000011118 Meleagris gallopavo ENSMGAG00000011118 N 0.757
ENSMGAG00000006532 Meleagris gallopavo ENSMGAG00000006532 N 0.818
ENSMICG00000015729 Microcebus murinus ENSMICG00000015729 I 0.865
ENSMICG00000005972 Microcebus murinus ENSMICG00000005972 I 0.808
ENSMODG00000012526 Monodelphis domestica ENSMODG00000012526 I 0.736
TBR1 Monodelphis domestica ENSMODG00000005353 I 0.920
ENSMPUG00000011981 Mustela putorius furo ENSMPUG00000011981 I 0.865
ENSMPUG00000015272 Mustela putorius furo ENSMPUG00000015272 I 0.766
ENSMPUG00000000551 Mustela putorius furo ENSMPUG00000000551 I 0.920
Eomes Mus musculus ENSMUSG00000032446 D 0.865
Tbx21 Mus musculus ENSMUSG00000001444 D 0.766
Tbr1 Mus musculus ENSMUSG00000035033 D 0.920
T Mus musculus ENSMUSG00000062327 D 0.768
Myotis_brandtii_KPNB1_10030428 Myotis brandtii Myotis_brandtii_KPNB1_10030428 I 0.766
Myotis_brandtii_SLC4A10_10035570 Myotis brandtii Myotis_brandtii_SLC4A10_10035570 I 0.913
Myotis_brandtii_Eomes_10021705 Myotis brandtii Myotis_brandtii_Eomes_10021705 N 0.771
TBR1 Myotis lucifugus ENSMLUG00000006008 I 0.908
EOMES Myotis lucifugus ENSMLUG00000001462 I 0.861
TBX21 Myotis lucifugus ENSMLUG00000014542 I 0.763
NBR_0001696801 Nippostrongylus brasiliensis NBR_0001696801 N 0.803
ENSNLEG00000004050 Nomascus leucogenys ENSNLEG00000004050 I 0.865
ENSNLEG00000002040 Nomascus leucogenys ENSNLEG00000002040 I 0.920
ENSNLEG00000001655 Nomascus leucogenys ENSNLEG00000001655 I 0.766
TBR1 Ochotona princeps ENSOPRG00000005150 I 0.918
Ocbimv22013221m.g Octopus bimaculoides Ocbimv22013221m.g N 0.756
Ogr17175 Ophisaurus gracilis Ogr17175 I 0.873
Ogr12599 Ophisaurus gracilis Ogr12599 N 0.799
ENSONIG00000018223 Oreochromis niloticus ENSONIG00000018223 I 0.871
ENSONIG00000019678 Oreochromis niloticus ENSONIG00000019678 I 0.843
ENSONIG00000007180 Oreochromis niloticus ENSONIG00000007180 I 0.868
ENSONIG00000008933 Oreochromis niloticus ENSONIG00000008933 I 0.902
ENSOANG00000012287 Ornithorhynchus anatinus ENSOANG00000012287 N 0.738
ENSOANG00000028644 Ornithorhynchus anatinus ENSOANG00000028644 N 0.900
EOMES Ornithorhynchus anatinus ENSOANG00000012619 I 0.783
TBR1 Oryctolagus cuniculus ENSOCUG00000005884 I 0.920
ENSOCUG00000000451 Oryctolagus cuniculus ENSOCUG00000000451 I 0.865
TBX21 Oryctolagus cuniculus ENSOCUG00000012907 I 0.766
eomesa Oryzias latipes ENSORLG00000002320 I 0.846
eomesb Oryzias latipes ENSORLG00000005393 I 0.850
tbr1b Oryzias latipes ENSORLG00000016828 I 0.902
tbx21 Oryzias latipes ENSORLG00000012193 N 0.826
TBR1 Otolemur garnettii ENSOGAG00000004936 I 0.920
TBX21 Otolemur garnettii ENSOGAG00000006160 I 0.766
EOMES Otolemur garnettii ENSOGAG00000030966 I 0.865
ENSOARG00000014467 Ovis aries ENSOARG00000014467 I 0.865
ENSOARG00000006620 Ovis aries ENSOARG00000006620 I 0.920
ENSOARG00000008340 Ovis aries ENSOARG00000008340 I 0.766
EOMES Pan troglodytes ENSPTRG00000014705 I 0.865
TBX21 Pan troglodytes ENSPTRG00000009335 I 0.766
TBR1 Pan troglodytes ENSPTRG00000012576 I 0.920
ENSPANG00000011539 Papio anubis ENSPANG00000011539 I 0.865
ENSPANG00000018688 Papio anubis ENSPANG00000018688 I 0.920
A0A075Q982_PATMI Patiria miniata A0A075Q982_PATMI D 0.789
ENSPSIG00000005360 Pelodiscus sinensis ENSPSIG00000005360 I 0.873
ENSPSIG00000004373 Pelodiscus sinensis ENSPSIG00000004373 I 0.920
ENSPMAG00000003985 Petromyzon marinus ENSPMAG00000003985 I 0.815
ENSPFOG00000018019 Poecilia formosa ENSPFOG00000018019 I 0.870
ENSPFOG00000017938 Poecilia formosa ENSPFOG00000017938 I 0.863
ENSPFOG00000006471 Poecilia formosa ENSPFOG00000006471 I 0.846
ENSPFOG00000017461 Poecilia formosa ENSPFOG00000017461 I 0.902
Pvit_15940 Pogona vitticeps Pvit_15940 I 0.920
Pvit_13952 Pogona vitticeps Pvit_13952 N 0.799
Pvit_16634 Pogona vitticeps Pvit_16634 I 0.748
ENSPPYG00000014055 Pongo abelii ENSPPYG00000014055 I 0.865
ENSPPYG00000012882 Pongo abelii ENSPPYG00000012882 I 0.920
ENSPPYG00000011585 Pongo abelii ENSPPYG00000011585 N 0.743
ENSPPYG00000008879 Pongo abelii ENSPPYG00000008879 I 0.766
EOMES Procavia capensis ENSPCAG00000013650 I 0.865
TBX21 Pteropus vampyrus ENSPVAG00000004921 I 0.766
EOMES Pteropus vampyrus ENSPVAG00000009999 I 0.752
Tbr1 Rattus norvegicus ENSRNOG00000005049 I 0.857
Tbx21 Rattus norvegicus ENSRNOG00000009427 I 0.770
Sakowv30001714m.g Saccoglossus kowalevskii Sakowv30001714m.g I 0.763
Sakowv30002752m.g Saccoglossus kowalevskii Sakowv30002752m.g I 0.815
ENSSHAG00000016616 Sarcophilus harrisii ENSSHAG00000016616 I 0.920
ENSSHAG00000018315 Sarcophilus harrisii ENSSHAG00000018315 I 0.736
ENSSHAG00000017378 Sarcophilus harrisii ENSSHAG00000017378 I 0.865
L893_g18550 Steinernema glaseri L893_g18550 N 0.803
SPU_025584 Strongylocentrotus purpuratus SPU_025584 D 0.762
TBX21 Sus scrofa ENSSSCG00000017517 I 0.766
ENSSSCG00000011219 Sus scrofa ENSSSCG00000011219 I 0.865
ENSSSCG00000022626 Sus scrofa ENSSSCG00000022626 I 0.865
ENSTGUG00000003557 Taeniopygia guttata ENSTGUG00000003557 N 0.782
ENSTGUG00000006709 Taeniopygia guttata ENSTGUG00000006709 N 0.920
ENSTRUG00000007811 Takifugu rubripes ENSTRUG00000007811 N 0.756
tbx21 Takifugu rubripes ENSTRUG00000012995 I 0.870
tbr1b Takifugu rubripes ENSTRUG00000005183 I 0.881
eomesa Takifugu rubripes ENSTRUG00000005361 I 0.846
eomesb Takifugu rubripes ENSTRUG00000008966 I 0.863
ENSTSYG00000004047 Tarsius syrichta ENSTSYG00000004047 N 0.817
tbx21 Tetraodon nigroviridis ENSTNIG00000010103 I 0.870
tbr1b Tetraodon nigroviridis ENSTNIG00000016497 I 0.841
eomesa Tetraodon nigroviridis ENSTNIG00000017582 I 0.846
eomesb Tetraodon nigroviridis ENSTNIG00000019116 I 0.868
TBR1 Tupaia belangeri ENSTBEG00000014183 I 0.920
ENSTTRG00000006645 Tursiops truncatus ENSTTRG00000006645 I 0.825
Tal_R010698 Tyto alba Tal_R010698 N 0.769
ENSVPAG00000011101 Vicugna pacos ENSVPAG00000011101 I 0.776
ENSVPAG00000002720 Vicugna pacos ENSVPAG00000002720 I 0.918
eomes.S Xenopus laevis XB-GENE-6487182 I 0.873
tbx5.S Xenopus laevis XB-GENE-6253071 N 0.784
eomes.L Xenopus laevis XB-GENE-865305 I 0.851
tbx4.L Xenopus laevis XB-GENE-951383 N 0.767
tbr1 Xenopus tropicalis XB-GENE-942241 I 0.920
eomes Xenopus tropicalis XB-GENE-479769 I 0.873
tbx21 Xenopus tropicalis XB-GENE-479103 I 0.843
AAI66068 Xenopus tropicalis AAI66068 I 0.846
ENSXMAG00000014284 Xiphophorus maculatus ENSXMAG00000014284 I 0.842
ENSXMAG00000000528 Xiphophorus maculatus ENSXMAG00000000528 I 0.846
ENSXMAG00000013655 Xiphophorus maculatus ENSXMAG00000013655 I 0.870
ENSXMAG00000011427 Xiphophorus maculatus ENSXMAG00000011427 I 0.902