Tbx6 (Mus musculus)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSMUSG00000030699 T340145_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of neuron maturation; regulation of gene expression; and somite rostral/caudal axis specification. Located in chromatin and nucleus. Is expressed in several structures, including 4-cell stage embryo; embryo ectoderm; embryo mesenchyme; genitourinary system; and primitive streak. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TBX6
M05805_2.00 		Homo sapiens
NRSGTGTBAN
NTVACACSYN		 SELEX
Yin et al.(2017)
TBX6_eDBD_HT-SELEX 		0.884 0.956
TBX6
M05806_2.00 		Homo sapiens
NTVRCACBHN
NDVGTGYBAN		 SELEX
Yin et al.(2017)
TBX6_eDBD_Methyl-HT-SELEX 		0.884 0.956
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000091579 T-box 93 273
ENSMUSP00000126418 T-box 93 273

Links

Other T-box family TFs
Other Mus musculus TFs

Invalid Input OrderBy

35 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action