Tbx21 (Rattus norvegicus)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSRNOG00000009427 T340429_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of T-helper 17 cell lineage commitment; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of gene expression. Predicted to act upstream of or within T cell differentiation; cellular response to organic substance; and positive regulation of isotype switching to IgG isotypes. Predicted to be located in neuronal cell body and nucleus. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TBX21
M03546_2.00 		Homo sapiens
GGTGTGAHDTMACACY
RGTGTKAHDTCACACC		 SELEX
Jolma et al.(2013)
TBX21_1 		0.915 0.945
TBX21
M03547_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_2 		0.915 0.945
TBX21
M03548_2.00 		Homo sapiens
TMACACYTNNDAGGTGTGA
TCACACCTHNNARGTGTKA		 SELEX
Jolma et al.(2013)
TBX21_3 		0.915 0.945
TBX21
M03549_2.00 		Homo sapiens
GGTGTGAWATCACACC
GGTGTGATWTCACACC		 SELEX
Jolma et al.(2013)
TBX21_4 		0.915 0.945
TBX21
M03550_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_5 		0.915 0.945
TBX21
M03551_2.00 		Homo sapiens
TSACACCWNMRAGGTGTGA
TCACACCTYKNWGGTGTSA		 SELEX
Jolma et al.(2013)
TBX21_6 		0.915 0.945
TBX21
M05793_2.00 		Homo sapiens
DAGGTGTKAN
NTMACACCTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_HT-SELEX 		0.915 0.945
TBX21
M09425_2.00 		Homo sapiens
NDSDRGSTGWBRN
NYVWCASCYHSHN		 Misc
Kulakovskiy et al.(2013)
TBX21_HUMAN.H11MO.0.A 		0.915 0.945
Tbx21
M09428_2.00 		Mus musculus
DNDDSTGWSDND
HNHSWCASHHNH		 Misc
Kulakovskiy et al.(2013)
TBX21_MOUSE.H11MO.0.A 		0.915 0.945
Tbx21
M09648_2.00 		Mus musculus
ADGTGWSAHN
NDTSWCACHT		 Misc
Heinz et al.(2010)
CD8-Tbet_GSE33802 		0.915 0.945
TBX21
M05794_2.00 		Homo sapiens
DASGTGTKAW
WTMACACSTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_Methyl-HT-SELEX 		0.915 0.945
Eomes
M00215_2.00 		Mus musculus
RDGTGYBANN
NNTVRCACHY		 PBM
Badis et al.(2009)
Eomes_0921 		0.817 0.749
EOMES
M03563_2.00 		Homo sapiens
DAGGTGTGAWNNN
NNNWTCACACCTH		 SELEX
Jolma et al.(2013)
EOMES_1 		0.817 0.743
EOMES
M03564_2.00 		Homo sapiens
TVACACNTNNNDRNGTGTGA
TCACACNYHNNNANGTGTBA		 SELEX
Jolma et al.(2013)
EOMES_2 		0.817 0.743
EOMES
M02752_2.00 		Homo sapiens
AGGTGTGAW
WTCACACCT		 SELEX
Jolma et al.(2010)
EOMES_monomer 		0.817 0.743
EOMES
M05807_2.00 		Homo sapiens
DAGGTGTGAN
NTCACACCTH		 SELEX
Yin et al.(2017)
EOMES_eDBD_HT-SELEX 		0.817 0.743
EOMES
M09647_2.00 		Homo sapiens
ARGTGWKAAN
NTTMWCACYT		 Misc
Heinz et al.(2010)
H9-Eomes_GSE26097 		0.817 0.743
EOMES
M05808_2.00 		Homo sapiens
NABGTGYKAH
DTMRCACVTN		 SELEX
Yin et al.(2017)
EOMES_eDBD_Methyl-HT-SELEX 		0.817 0.743
Tbr1
M01028_2.00 		Mus musculus
DTVRCAMNYH
DRNKTGYBAH		 PBM
SebePedros et al.(2013)
pTH2659 		0.770 0.738
TBR1
M03560_2.00 		Homo sapiens
AGGTGTGAAN
NTTCACACCT		 SELEX
Jolma et al.(2013)
TBR1_1 		0.770 0.738
TBR1
M03561_2.00 		Homo sapiens
RAGGTGTGAAH
DTTCACACCTY		 SELEX
Jolma et al.(2013)
TBR1_2 		0.770 0.738
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000012538 T-box 138 324

Links

Other T-box family TFs
Other Rattus norvegicus TFs

161 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Tbx21 Dipodomys ordii ENSDORG00000013302 I 0.915
TBX21 Sus scrofa ENSSSCG00000017517 I 0.915
TBX21 Canis familiaris ENSCAFG00000016705 I 0.915
TBX21 Felis catus ENSFCAG00000010607 I 0.915
ENSOARG00000008340 Ovis aries ENSOARG00000008340 I 0.915
TBX21 Homo sapiens ENSG00000073861 D 0.915
TBX21 Pan troglodytes ENSPTRG00000009335 I 0.915
ENSCSAG00000002587 Chlorocebus sabaeus ENSCSAG00000002587 I 0.915
ENSPPYG00000008879 Pongo abelii ENSPPYG00000008879 I 0.915
ENSMPUG00000015272 Mustela putorius furo ENSMPUG00000015272 I 0.915
ENSSTOG00000001626 Ictidomys tridecemlineatus ENSSTOG00000001626 I 0.915
TBX21 Gorilla gorilla ENSGGOG00000002208 I 0.915
Myotis_brandtii_KPNB1_10030428 Myotis brandtii Myotis_brandtii_KPNB1_10030428 I 0.915
TBX21 Otolemur garnettii ENSOGAG00000006160 I 0.915
ENSAMEG00000004661 Ailuropoda melanoleuca ENSAMEG00000004661 I 0.915
Tbx21 Mus musculus ENSMUSG00000001444 D 0.915
TBX21 Macaca mulatta ENSMMUG00000007098 I 0.915
ENSP00000177694 Macaca fascicularis ENSP00000177694 I 0.915
TBX21 Myotis lucifugus ENSMLUG00000014542 I 0.913
TBX21 Bos taurus ENSBTAG00000014199 I 0.912
ENSBTAP00000018875-D1 Bos grunniens ENSBTAP00000018875-D1 I 0.912
TBX21 Oryctolagus cuniculus ENSOCUG00000012907 I 0.908
TBX21 Callithrix jacchus ENSCJAG00000007796 I 0.907
ENSNLEG00000001655 Nomascus leucogenys ENSNLEG00000001655 I 0.906
TBX21 Pteropus vampyrus ENSPVAG00000004921 I 0.888
TBX21 Cavia porcellus ENSCPOG00000026273 I 0.875
ENSMODG00000012526 Monodelphis domestica ENSMODG00000012526 I 0.830
ENSSHAG00000018315 Sarcophilus harrisii ENSSHAG00000018315 I 0.830
ENSMICG00000015729 Microcebus murinus ENSMICG00000015729 I 0.817
ENSMMUG00000001904 Macaca mulatta ENSMMUG00000001904 I 0.817
Eomes Mus musculus ENSMUSG00000032446 D 0.817
ENSNLEG00000004050 Nomascus leucogenys ENSNLEG00000004050 I 0.817
ENSMPUG00000011981 Mustela putorius furo ENSMPUG00000011981 I 0.817
ENSPSIG00000005360 Pelodiscus sinensis ENSPSIG00000005360 I 0.817
ENSSTOG00000020918 Ictidomys tridecemlineatus ENSSTOG00000020918 I 0.817
ENSSSCG00000022626 Sus scrofa ENSSSCG00000022626 I 0.817
ENSP00000388620 Macaca fascicularis ENSP00000388620 I 0.817
Ogr17175 Ophisaurus gracilis Ogr17175 I 0.817
eomes.S Xenopus laevis XB-GENE-6487182 I 0.817
eomes Xenopus tropicalis XB-GENE-479769 I 0.817
ENSSSCG00000011219 Sus scrofa ENSSSCG00000011219 I 0.817
ENSSHAG00000017378 Sarcophilus harrisii ENSSHAG00000017378 I 0.817
ENSPANG00000011539 Papio anubis ENSPANG00000011539 I 0.817
EOMES Otolemur garnettii ENSOGAG00000030966 I 0.817
EOMES Procavia capensis ENSPCAG00000013650 I 0.817
ENSPPYG00000014055 Pongo abelii ENSPPYG00000014055 I 0.817
EOMES Pan troglodytes ENSPTRG00000014705 I 0.817
EOMES Loxodonta africana ENSLAFG00000004142 I 0.817
ENSOARG00000014467 Ovis aries ENSOARG00000014467 I 0.817
ENSOCUG00000000451 Oryctolagus cuniculus ENSOCUG00000000451 I 0.817
EOMES Gallus gallus ENSGALG00000027247 I 0.817
EOMES Gorilla gorilla ENSGGOG00000008358 I 0.817
ENSAMEG00000012731 Ailuropoda melanoleuca ENSAMEG00000012731 I 0.817
EOMES Erinaceus europaeus ENSEEUG00000005958 I 0.817
ENSFALG00000009181 Ficedula albicollis ENSFALG00000009181 I 0.817
EOMES Felis catus ENSFCAG00000003602 I 0.817
EOMES Homo sapiens ENSG00000163508 D 0.817
EOMES Bos taurus ENSBTAG00000016920 I 0.817
Eomes Dipodomys ordii ENSDORG00000016346 I 0.817
EOMES Anolis carolinensis ENSACAG00000014201 I 0.817
EOMES Cavia porcellus ENSCPOG00000004381 I 0.817
EOMES Canis familiaris ENSCAFG00000005510 I 0.817
ENSLOCG00000002398 Lepisosteus oculatus ENSLOCG00000002398 I 0.815
EOMES Equus caballus ENSECAG00000021052 I 0.813
EOMES Myotis lucifugus ENSMLUG00000001462 I 0.813
EOMES Callithrix jacchus ENSCJAG00000004263 I 0.812
ENSPANG00000022107 Papio anubis ENSPANG00000022107 I 0.805
Alligator_sinensis_CCG014450.1 Alligator sinensis Alligator_sinensis_CCG014450.1 I 0.800
ENSAMXG00000010492 Astyanax mexicanus ENSAMXG00000010492 I 0.800
tbx21 Danio rerio ENSDARG00000004473 I 0.800
ENSONIG00000018223 Oreochromis niloticus ENSONIG00000018223 I 0.798
tbx21 Tetraodon nigroviridis ENSTNIG00000010103 I 0.797
ENSPFOG00000018019 Poecilia formosa ENSPFOG00000018019 I 0.797
tbx21 Takifugu rubripes ENSTRUG00000012995 I 0.797
ENSXMAG00000013655 Xiphophorus maculatus ENSXMAG00000013655 I 0.797
ENSLOCG00000013335 Lepisosteus oculatus ENSLOCG00000013335 I 0.797
eomes.L Xenopus laevis XB-GENE-865305 I 0.794
ENSGMOG00000002634 Gadus morhua ENSGMOG00000002634 I 0.793
eomesb Tetraodon nigroviridis ENSTNIG00000019116 I 0.793
ENSONIG00000007180 Oreochromis niloticus ENSONIG00000007180 I 0.793
eomesa Gasterosteus aculeatus ENSGACG00000003160 I 0.793
eomesb Takifugu rubripes ENSTRUG00000008966 I 0.790
Brh_R007719 Buceros rhinoceros Brh_R007719 I 0.790
eomesa Takifugu rubripes ENSTRUG00000005361 I 0.790
eomesa Oryzias latipes ENSORLG00000002320 I 0.790
eomesa Tetraodon nigroviridis ENSTNIG00000017582 I 0.790
AAI66068 Xenopus tropicalis AAI66068 I 0.790
eomesa Danio rerio ENSDARG00000006640 I 0.790
ENSAMXG00000012247 Astyanax mexicanus ENSAMXG00000012247 I 0.790
ENSPFOG00000017938 Poecilia formosa ENSPFOG00000017938 I 0.790
ENSXMAG00000000528 Xiphophorus maculatus ENSXMAG00000000528 I 0.790
ENSP00000388620-D1 Bos grunniens ENSP00000388620-D1 I 0.790
ENSPFOG00000006471 Poecilia formosa ENSPFOG00000006471 I 0.790
ENSONIG00000019678 Oreochromis niloticus ENSONIG00000019678 I 0.787
eomesb Oryzias latipes ENSORLG00000005393 I 0.784
ENSLACG00000016985 Latimeria chalumnae ENSLACG00000016985 I 0.777
eomesb Gasterosteus aculeatus ENSGACG00000006345 I 0.771
ENSP00000374205-D1 Bos grunniens ENSP00000374205-D1 I 0.770
TBR1 Canis familiaris ENSCAFG00000009984 I 0.770
Alligator_sinensis_CCG012002.1 Alligator sinensis Alligator_sinensis_CCG012002.1 I 0.770
tbr1 Xenopus tropicalis XB-GENE-942241 I 0.770
ENSAMEG00000012360 Ailuropoda melanoleuca ENSAMEG00000012360 I 0.770
TBR1 Callithrix jacchus ENSCJAG00000005603 I 0.770
ENSSTOG00000023843 Ictidomys tridecemlineatus ENSSTOG00000023843 I 0.770
ENSP00000374205 Macaca fascicularis ENSP00000374205 I 0.770
Pvit_15940 Pogona vitticeps Pvit_15940 I 0.770
TBR1 Tupaia belangeri ENSTBEG00000014183 I 0.770
ENSXMAG00000011427 Xiphophorus maculatus ENSXMAG00000011427 I 0.770
Myotis_brandtii_SLC4A10_10035570 Myotis brandtii Myotis_brandtii_SLC4A10_10035570 I 0.770
ENSCPOG00000005881 Cavia porcellus ENSCPOG00000005881 I 0.770
TBR1 Bos taurus ENSBTAG00000021692 I 0.770
ENSPSIG00000004373 Pelodiscus sinensis ENSPSIG00000004373 I 0.770
TBR1 Oryctolagus cuniculus ENSOCUG00000005884 I 0.770
TBR1 Macaca mulatta ENSMMUG00000011911 I 0.770
ENSFALG00000004466 Ficedula albicollis ENSFALG00000004466 I 0.770
TBR1 Gorilla gorilla ENSGGOG00000015752 I 0.770
TBR1 Otolemur garnettii ENSOGAG00000004936 I 0.770
TBR1 Monodelphis domestica ENSMODG00000005353 I 0.770
ENSOARG00000006620 Ovis aries ENSOARG00000006620 I 0.770
TBR1 Homo sapiens ENSG00000136535 D 0.770
Tbr1 Mus musculus ENSMUSG00000035033 D 0.770
ENSNLEG00000002040 Nomascus leucogenys ENSNLEG00000002040 I 0.770
ENSSHAG00000016616 Sarcophilus harrisii ENSSHAG00000016616 I 0.770
ENSMPUG00000000551 Mustela putorius furo ENSMPUG00000000551 I 0.770
ENSONIG00000008933 Oreochromis niloticus ENSONIG00000008933 I 0.770
TBR1 Ochotona princeps ENSOPRG00000005150 I 0.770
eomesb Danio rerio ENSDARG00000104243 I 0.770
ENSPPYG00000012882 Pongo abelii ENSPPYG00000012882 I 0.770
TBR1 Loxodonta africana ENSLAFG00000011541 I 0.770
TBR1 Pan troglodytes ENSPTRG00000012576 I 0.770
ENSCSAG00000015663 Chlorocebus sabaeus ENSCSAG00000015663 I 0.770
tbr1b Gasterosteus aculeatus ENSGACG00000005648 I 0.770
ENSLOCG00000008583 Lepisosteus oculatus ENSLOCG00000008583 I 0.770
ENSPFOG00000017461 Poecilia formosa ENSPFOG00000017461 I 0.770
tbr1b Oryzias latipes ENSORLG00000016828 I 0.770
ENSPANG00000018688 Papio anubis ENSPANG00000018688 I 0.770
TBR1 Dasypus novemcinctus ENSDNOG00000009816 I 0.770
ENSLACG00000003893 Latimeria chalumnae ENSLACG00000003893 I 0.769
ENSGMOG00000014981 Gadus morhua ENSGMOG00000014981 I 0.769
ENSAMXG00000009990 Astyanax mexicanus ENSAMXG00000009990 I 0.768
TBR1 Felis catus ENSFCAG00000025073 I 0.768
tbr1b Danio rerio ENSDARG00000004712 I 0.768
ENSVPAG00000002720 Vicugna pacos ENSVPAG00000002720 I 0.768
ENSXMAG00000014284 Xiphophorus maculatus ENSXMAG00000014284 I 0.767
TBX21 Loxodonta africana ENSLAFG00000028463 I 0.764
ENSGMOG00000003675 Gadus morhua ENSGMOG00000003675 I 0.759
TBR1 Myotis lucifugus ENSMLUG00000006008 I 0.759
tbx21 Xenopus tropicalis XB-GENE-479103 I 0.756
csin100383 Clonorchis sinensis csin100383 I 0.754
T265_12717 Opisthorchis viverrini T265_12717 I 0.754
Sjc_0040480 Schistosoma japonicum Sjc_0040480 I 0.752
Sakowv30012255m.g Saccoglossus kowalevskii Sakowv30012255m.g I 0.752
tbr1b Takifugu rubripes ENSTRUG00000005183 I 0.749
EOMES Ornithorhynchus anatinus ENSOANG00000012619 I 0.749
D915_09218 Fasciola hepatica D915_09218 I 0.748
Smp_003900 Schistosoma mansoni Smp_003900 I 0.747
Ocbimv22029974m.g Octopus bimaculoides Ocbimv22029974m.g I 0.746
SMU15033270 Schmidtea mediterranea SMU15033270 I 0.738
CGI_10020437 Crassostrea gigas CGI_10020437 I 0.737
MCOS_0000012101 Mesocestoides corti MCOS_0000012101 I 0.736
tbr1a Danio rerio ENSDARG00000076259 I 0.735