Tbx18 (Rattus norvegicus)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 ENSRNOG00000010685 T340430_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; sinoatrial node cell differentiation; and somitogenesis. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and sensory perception of sound. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription repressor complex. Human ortholog(s) of this gene implicated in CAKUT2. Orthologous to human TBX18 (T-box transcription factor 18). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TBX18
M05797_2.00 		Homo sapiens
DDAGGTGTGARV
BYTCACACCTHH		 SELEX
Yin et al.(2017)
TBX18_eDBD_HT-SELEX 		0.905 0.995
TBX18
M11380_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX18_01 		0.905 0.995
TBX18
M05798_2.00 		Homo sapiens
NDAGGYGTGAAN
NTTCACRCCTHN		 SELEX
Yin et al.(2017)
TBX18_eDBD_Methyl-HT-SELEX 		0.905 0.995
TBX15
M03554_2.00 		Homo sapiens
AGGTGTGAAATTCACACCT
AGGTGTGAATTTCACACCT		 SELEX
Jolma et al.(2013)
TBX15_1 		0.886 0.923
TBX15
M03555_2.00 		Homo sapiens
AGGTGTGA
TCACACCT		 SELEX
Jolma et al.(2013)
TBX15_2 		0.886 0.923
TBX15
M05795_2.00 		Homo sapiens
NRSGTGTBAN
NTVACACSYN		 SELEX
Yin et al.(2017)
TBX15_eDBD_HT-SELEX 		0.886 0.923
TBX15
M11378_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX15_01 		0.886 0.923
TBX15
M11379_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX15_02 		0.886 0.923
TBX15
M05796_2.00 		Homo sapiens
NDSGYGTBAN
NTVACRCSHN		 SELEX
Yin et al.(2017)
TBX15_eDBD_Methyl-HT-SELEX 		0.886 0.923
TBX22
M11383_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX22_01 		0.815 0.736
mid
M03994_2.00 		Drosophila melanogaster
DAGGTGTKAN
NTMACACCTH		 SELEX
Nitta et al.(2015)
mid_1 		0.776 0.604
Tbx20
M00835_2.00 		Mus musculus
NRRGTGTBAN
NTVACACYYN		 PBM
Weirauch et al.(2013)
pTH3777 		0.767 0.665
TBX20
M03565_2.00 		Homo sapiens
AGGTGTKARVGYGTGA
TCACRCBYTMACACCT		 SELEX
Jolma et al.(2013)
TBX20_1 		0.767 0.665
TBX20
M03566_2.00 		Homo sapiens
AGGTGTGAAWDTSACACBT
AVGTGTSAHWTTCACACCT		 SELEX
Jolma et al.(2013)
TBX20_2 		0.767 0.665
TBX20
M03567_2.00 		Homo sapiens
NNNDAGGTGTGAAND
HNTTCACACCTHNNN		 SELEX
Jolma et al.(2013)
TBX20_3 		0.767 0.665
TBX20
M03568_2.00 		Homo sapiens
DAGGTGTGAWR
YWTCACACCTH		 SELEX
Jolma et al.(2013)
TBX20_4 		0.767 0.665
TBX20
M03569_2.00 		Homo sapiens
AGGTGTKANGKTGTSA
TSACAMCNTMACACCT		 SELEX
Jolma et al.(2013)
TBX20_5 		0.767 0.665
TBX20
M05813_2.00 		Homo sapiens
DAGGTGTKARSGTGTGAA
TTCACACSYTMACACCTH		 SELEX
Yin et al.(2017)
TBX20_eDBD_HT-SELEX_1 		0.767 0.665
TBX20
M05814_2.00 		Homo sapiens
NAGGTGTGAAWTTCACACCTN
NAGGTGTGAAWTTCACACCTN		 SELEX
Yin et al.(2017)
TBX20_eDBD_HT-SELEX_2 		0.767 0.665
TBX20
M05817_2.00 		Homo sapiens
DRRGTGTBADVGYGTBAN
NTVACRCBHTVACACYYH		 SELEX
Yin et al.(2017)
TBX20_FL_HT-SELEX_1 		0.767 0.665
TBX20
M05818_2.00 		Homo sapiens
WTCACACYTAGGTGTKAM
KTMACACCTARGTGTGAW		 SELEX
Yin et al.(2017)
TBX20_FL_HT-SELEX_2 		0.767 0.665
Tbx20
M09430_2.00 		Mus musculus
NDSTGNTGACAGSN
NSCTGTCANCASHN		 Misc
Kulakovskiy et al.(2013)
TBX20_MOUSE.H11MO.0.C 		0.767 0.665
Tbx20
M09650_2.00 		Mus musculus
SCTGTCADCASN
NSTGHTGACAGS		 Misc
Heinz et al.(2010)
Heart-Tbx20_GSE29636 		0.767 0.665
TBX20
M11385_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX20_05 		0.767 0.665
TBX20
M05815_2.00 		Homo sapiens
DAGGTGTKAASGYGTKAA
TTMACRCSTTMACACCTH		 SELEX
Yin et al.(2017)
TBX20_eDBD_Methyl-HT-SELEX_1 		0.767 0.665
TBX20
M05816_2.00 		Homo sapiens
DASGTGTGAWWWTCACACCTH
DAGGTGTGAWWWTCACACSTH		 SELEX
Yin et al.(2017)
TBX20_eDBD_Methyl-HT-SELEX_2 		0.767 0.665
TBX20
M05819_2.00 		Homo sapiens
DRGGYGTBARVGYGTKAN
NTMACRCBYTVACRCCYH		 SELEX
Yin et al.(2017)
TBX20_FL_Methyl-HT-SELEX_1 		0.767 0.665
TBX20
M05820_2.00 		Homo sapiens
TTMACRCCTAVGTGTGAA
TTCACACBTAGGYGTKAA		 SELEX
Yin et al.(2017)
TBX20_FL_Methyl-HT-SELEX_2 		0.767 0.665
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000014657 T-box 147 336

Links

Other T-box family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

264 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action