org-1 (Drosophila melanogaster)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 FBgn0021767 T340629_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity. Involved in positive regulation of transcription by RNA polymerase II and somatic muscle development. Predicted to be located in nucleus. Is expressed in abdominal lateral adult muscle precursor cell; embryonic somatic muscle cell; embryonic/larval muscle cell; trunk mesoderm; and visceral muscle primordium. Human ortholog(s) of this gene implicated in DiGeorge syndrome; tetralogy of Fallot; and velocardiofacial syndrome. Orthologous to several human genes including TBX1 (T-box transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
org-1
M03988_2.00		 Drosophila melanogaster
DRGTGTBAD
HTVACACYH		 SELEX
Nitta et al.(2015)
org-1_1		 (Direct) (Direct)
org-1
M03989_2.00		 Drosophila melanogaster
TRACACYTARGTGTGA
TCACACYTARGTGTYA		 SELEX
Nitta et al.(2015)
org-1_2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbx1
M00832_2.00 		Mus musculus
NRGTGTGAANN
NNTTCACACYN		 PBM
Weirauch et al.(2013)
pTH3822 		0.739 0.725
TBX1
M03570_2.00 		Homo sapiens
ARGTGTKAAAWHARGTGTGA
TCACACYTDWTTTMACACYT		 SELEX
Jolma et al.(2013)
TBX1_1 		0.739 0.725
TBX1
M03571_2.00 		Homo sapiens
AGGTGTGAWWTTCACACCT
AGGTGTGAAWWTCACACCT		 SELEX
Jolma et al.(2013)
TBX1_2 		0.739 0.725
TBX1
M03572_2.00 		Homo sapiens
AGGTGTGA
TCACACCT		 SELEX
Jolma et al.(2013)
TBX1_3 		0.739 0.725
TBX1
M03573_2.00 		Homo sapiens
YYTCACACMTYWRAGGTGTGAAA
TTTCACACCTYWRAKGTGTGARR		 SELEX
Jolma et al.(2013)
TBX1_4 		0.739 0.725
TBX1
M03574_2.00 		Homo sapiens
YTCACACCTDKAGGTGTGAA
TTCACACCTMHAGGTGTGAR		 SELEX
Jolma et al.(2013)
TBX1_5 		0.739 0.725
TBX1
M05821_2.00 		Homo sapiens
BDRGGTGTGARV
BYTCACACCYHV		 SELEX
Yin et al.(2017)
TBX1_eDBD_HT-SELEX 		0.739 0.725
Tbx1
M11386_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX1_07 		0.739 0.725
TBX1
M05822_2.00 		Homo sapiens
DNWGGTGTGARN
NYTCACACCWNH		 SELEX
Yin et al.(2017)
TBX1_eDBD_Methyl-HT-SELEX 		0.739 0.725
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0071187 T-box 198 385
FBpp0311870 T-box 198 385

Links

Other T-box family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

90 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action