ENSP00000374205 (Macaca fascicularis)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00907 (T-box) IPR001699 ENSP00000374205 T341072_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbr1
M01028_2.00 		Mus musculus
DTVRCAMNYH
DRNKTGYBAH		 PBM
SebePedros et al.(2013)
pTH2659 		0.920 1.000
TBR1
M03560_2.00 		Homo sapiens
AGGTGTGAAN
NTTCACACCT		 SELEX
Jolma et al.(2013)
TBR1_1 		0.920 1.000
TBR1
M03561_2.00 		Homo sapiens
RAGGTGTGAAH
DTTCACACCTY		 SELEX
Jolma et al.(2013)
TBR1_2 		0.920 1.000
Eomes
M00215_2.00 		Mus musculus
RDGTGYBANN
NNTVRCACHY		 PBM
Badis et al.(2009)
Eomes_0921 		0.865 0.874
EOMES
M03563_2.00 		Homo sapiens
DAGGTGTGAWNNN
NNNWTCACACCTH		 SELEX
Jolma et al.(2013)
EOMES_1 		0.865 0.869
EOMES
M03564_2.00 		Homo sapiens
TVACACNTNNNDRNGTGTGA
TCACACNYHNNNANGTGTBA		 SELEX
Jolma et al.(2013)
EOMES_2 		0.865 0.869
EOMES
M02752_2.00 		Homo sapiens
AGGTGTGAW
WTCACACCT		 SELEX
Jolma et al.(2010)
EOMES_monomer 		0.865 0.869
EOMES
M05807_2.00 		Homo sapiens
DAGGTGTGAN
NTCACACCTH		 SELEX
Yin et al.(2017)
EOMES_eDBD_HT-SELEX 		0.865 0.869
EOMES
M09647_2.00 		Homo sapiens
ARGTGWKAAN
NTTMWCACYT		 Misc
Heinz et al.(2010)
H9-Eomes_GSE26097 		0.865 0.869
EOMES
M05808_2.00 		Homo sapiens
NABGTGYKAH
DTMRCACVTN		 SELEX
Yin et al.(2017)
EOMES_eDBD_Methyl-HT-SELEX 		0.865 0.869
A0A075Q982_PATMI
M00734_2.00 		Patiria miniata
NAGGTGTBAN
NTVACACCTN		 PBM
Cheatle-Jarvela et al.(2014)
PmTbr 		0.789 0.645
TBX21
M03546_2.00 		Homo sapiens
GGTGTGAHDTMACACY
RGTGTKAHDTCACACC		 SELEX
Jolma et al.(2013)
TBX21_1 		0.766 0.732
TBX21
M03547_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_2 		0.766 0.732
TBX21
M03548_2.00 		Homo sapiens
TMACACYTNNDAGGTGTGA
TCACACCTHNNARGTGTKA		 SELEX
Jolma et al.(2013)
TBX21_3 		0.766 0.732
TBX21
M03549_2.00 		Homo sapiens
GGTGTGAWATCACACC
GGTGTGATWTCACACC		 SELEX
Jolma et al.(2013)
TBX21_4 		0.766 0.732
TBX21
M03550_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_5 		0.766 0.732
TBX21
M03551_2.00 		Homo sapiens
TSACACCWNMRAGGTGTGA
TCACACCTYKNWGGTGTSA		 SELEX
Jolma et al.(2013)
TBX21_6 		0.766 0.732
TBX21
M05793_2.00 		Homo sapiens
DAGGTGTKAN
NTMACACCTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_HT-SELEX 		0.766 0.732
TBX21
M09425_2.00 		Homo sapiens
NDSDRGSTGWBRN
NYVWCASCYHSHN		 Misc
Kulakovskiy et al.(2013)
TBX21_HUMAN.H11MO.0.A 		0.766 0.732
Tbx21
M09428_2.00 		Mus musculus
DNDDSTGWSDND
HNHSWCASHHNH		 Misc
Kulakovskiy et al.(2013)
TBX21_MOUSE.H11MO.0.A 		0.766 0.732
Tbx21
M09648_2.00 		Mus musculus
ADGTGWSAHN
NDTSWCACHT		 Misc
Heinz et al.(2010)
CD8-Tbet_GSE33802 		0.766 0.732
TBX21
M05794_2.00 		Homo sapiens
DASGTGTKAW
WTMACACSTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_Methyl-HT-SELEX 		0.766 0.732
SPU_025584
M00733_2.00 		Strongylocentrotus purpuratus
RGGTGTGANN
NNTCACACCY		 PBM
Cheatle-Jarvela et al.(2014)
SpTbr 		0.762 0.617
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000374205 T-box 206 393

Links

Other T-box family TFs
Other Macaca fascicularis TFs

166 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSSHAG00000016616 Sarcophilus harrisii ENSSHAG00000016616 I 0.920
ENSFALG00000004466 Ficedula albicollis ENSFALG00000004466 I 0.920
Tbr1 Mus musculus ENSMUSG00000035033 D 0.920
TBR1 Pan troglodytes ENSPTRG00000012576 I 0.920
TBR1 Otolemur garnettii ENSOGAG00000004936 I 0.920
ENSNLEG00000002040 Nomascus leucogenys ENSNLEG00000002040 I 0.920
TBR1 Tupaia belangeri ENSTBEG00000014183 I 0.920
ENSSTOG00000023843 Ictidomys tridecemlineatus ENSSTOG00000023843 I 0.920
TBR1 Dasypus novemcinctus ENSDNOG00000009816 I 0.920
TBR1 Homo sapiens ENSG00000136535 D 0.920
ENSPSIG00000004373 Pelodiscus sinensis ENSPSIG00000004373 I 0.920
TBR1 Monodelphis domestica ENSMODG00000005353 I 0.920
TBR1 Loxodonta africana ENSLAFG00000011541 I 0.920
TBR1 Macaca mulatta ENSMMUG00000011911 I 0.920
ENSPANG00000018688 Papio anubis ENSPANG00000018688 I 0.920
TBR1 Oryctolagus cuniculus ENSOCUG00000005884 I 0.920
ENSMPUG00000000551 Mustela putorius furo ENSMPUG00000000551 I 0.920
ENSPPYG00000012882 Pongo abelii ENSPPYG00000012882 I 0.920
TBR1 Gorilla gorilla ENSGGOG00000015752 I 0.920
ENSCSAG00000015663 Chlorocebus sabaeus ENSCSAG00000015663 I 0.920
ENSOARG00000006620 Ovis aries ENSOARG00000006620 I 0.920
TBR1 Canis familiaris ENSCAFG00000009984 I 0.920
TBR1 Callithrix jacchus ENSCJAG00000005603 I 0.920
TBR1 Bos taurus ENSBTAG00000021692 I 0.920
ENSAMEG00000012360 Ailuropoda melanoleuca ENSAMEG00000012360 I 0.920
tbr1 Xenopus tropicalis XB-GENE-942241 I 0.920
ENSCPOG00000005881 Cavia porcellus ENSCPOG00000005881 I 0.920
Pvit_15940 Pogona vitticeps Pvit_15940 I 0.920
ENSLACG00000003893 Latimeria chalumnae ENSLACG00000003893 I 0.918
ENSVPAG00000002720 Vicugna pacos ENSVPAG00000002720 I 0.918
TBR1 Ochotona princeps ENSOPRG00000005150 I 0.918
TBR1 Felis catus ENSFCAG00000025073 I 0.917
Myotis_brandtii_SLC4A10_10035570 Myotis brandtii Myotis_brandtii_SLC4A10_10035570 I 0.913
Alligator_sinensis_CCG012002.1 Alligator sinensis Alligator_sinensis_CCG012002.1 I 0.913
ENSP00000374205-D1 Bos grunniens ENSP00000374205-D1 I 0.913
ENSLOCG00000008583 Lepisosteus oculatus ENSLOCG00000008583 I 0.911
TBR1 Myotis lucifugus ENSMLUG00000006008 I 0.908
tbr1b Danio rerio ENSDARG00000004712 I 0.908
ENSAMXG00000009990 Astyanax mexicanus ENSAMXG00000009990 I 0.908
ENSPFOG00000017461 Poecilia formosa ENSPFOG00000017461 I 0.902
ENSXMAG00000011427 Xiphophorus maculatus ENSXMAG00000011427 I 0.902
tbr1b Gasterosteus aculeatus ENSGACG00000005648 I 0.902
tbr1b Oryzias latipes ENSORLG00000016828 I 0.902
ENSONIG00000008933 Oreochromis niloticus ENSONIG00000008933 I 0.902
ENSGMOG00000014981 Gadus morhua ENSGMOG00000014981 I 0.897
ENSLOCG00000013335 Lepisosteus oculatus ENSLOCG00000013335 I 0.881
tbr1b Takifugu rubripes ENSTRUG00000005183 I 0.881
tbx21 Danio rerio ENSDARG00000004473 I 0.874
EOMES Anolis carolinensis ENSACAG00000014201 I 0.873
eomes.S Xenopus laevis XB-GENE-6487182 I 0.873
EOMES Gallus gallus ENSGALG00000027247 I 0.873
Ogr17175 Ophisaurus gracilis Ogr17175 I 0.873
ENSPSIG00000005360 Pelodiscus sinensis ENSPSIG00000005360 I 0.873
ENSAMXG00000010492 Astyanax mexicanus ENSAMXG00000010492 I 0.873
ENSFALG00000009181 Ficedula albicollis ENSFALG00000009181 I 0.873
eomes Xenopus tropicalis XB-GENE-479769 I 0.873
ENSLOCG00000002398 Lepisosteus oculatus ENSLOCG00000002398 I 0.872
ENSONIG00000018223 Oreochromis niloticus ENSONIG00000018223 I 0.871
tbx21 Tetraodon nigroviridis ENSTNIG00000010103 I 0.870
ENSPFOG00000018019 Poecilia formosa ENSPFOG00000018019 I 0.870
ENSXMAG00000013655 Xiphophorus maculatus ENSXMAG00000013655 I 0.870
tbx21 Takifugu rubripes ENSTRUG00000012995 I 0.870
eomesb Tetraodon nigroviridis ENSTNIG00000019116 I 0.868
ENSONIG00000007180 Oreochromis niloticus ENSONIG00000007180 I 0.868
ENSOCUG00000000451 Oryctolagus cuniculus ENSOCUG00000000451 I 0.865
ENSNLEG00000004050 Nomascus leucogenys ENSNLEG00000004050 I 0.865
EOMES Pan troglodytes ENSPTRG00000014705 I 0.865
ENSSSCG00000011219 Sus scrofa ENSSSCG00000011219 I 0.865
ENSSSCG00000022626 Sus scrofa ENSSSCG00000022626 I 0.865
ENSSTOG00000020918 Ictidomys tridecemlineatus ENSSTOG00000020918 I 0.865
ENSSHAG00000017378 Sarcophilus harrisii ENSSHAG00000017378 I 0.865
ENSPPYG00000014055 Pongo abelii ENSPPYG00000014055 I 0.865
ENSPANG00000011539 Papio anubis ENSPANG00000011539 I 0.865
EOMES Procavia capensis ENSPCAG00000013650 I 0.865
EOMES Otolemur garnettii ENSOGAG00000030966 I 0.865
ENSOARG00000014467 Ovis aries ENSOARG00000014467 I 0.865
Eomes Dipodomys ordii ENSDORG00000016346 I 0.865
EOMES Erinaceus europaeus ENSEEUG00000005958 I 0.865
ENSMICG00000015729 Microcebus murinus ENSMICG00000015729 I 0.865
EOMES Gorilla gorilla ENSGGOG00000008358 I 0.865
EOMES Bos taurus ENSBTAG00000016920 I 0.865
EOMES Felis catus ENSFCAG00000003602 I 0.865
EOMES Canis familiaris ENSCAFG00000005510 I 0.865
EOMES Homo sapiens ENSG00000163508 D 0.865
ENSMMUG00000001904 Macaca mulatta ENSMMUG00000001904 I 0.865
EOMES Loxodonta africana ENSLAFG00000004142 I 0.865
EOMES Cavia porcellus ENSCPOG00000004381 I 0.865
Eomes Mus musculus ENSMUSG00000032446 D 0.865
ENSMPUG00000011981 Mustela putorius furo ENSMPUG00000011981 I 0.865
ENSAMEG00000012731 Ailuropoda melanoleuca ENSAMEG00000012731 I 0.865
eomesb Takifugu rubripes ENSTRUG00000008966 I 0.863
ENSPFOG00000017938 Poecilia formosa ENSPFOG00000017938 I 0.863
Alligator_sinensis_CCG014450.1 Alligator sinensis Alligator_sinensis_CCG014450.1 I 0.862
EOMES Myotis lucifugus ENSMLUG00000001462 I 0.861
EOMES Equus caballus ENSECAG00000021052 I 0.861
EOMES Callithrix jacchus ENSCJAG00000004263 I 0.860
Tbr1 Rattus norvegicus ENSRNOG00000005049 I 0.857
eomes.L Xenopus laevis XB-GENE-865305 I 0.851
eomesb Oryzias latipes ENSORLG00000005393 I 0.850
ENSGMOG00000002634 Gadus morhua ENSGMOG00000002634 I 0.849
eomesa Gasterosteus aculeatus ENSGACG00000003160 I 0.849
eomesb Danio rerio ENSDARG00000104243 I 0.848
eomesa Takifugu rubripes ENSTRUG00000005361 I 0.846
eomesb Gasterosteus aculeatus ENSGACG00000006345 I 0.846
ENSXMAG00000000528 Xiphophorus maculatus ENSXMAG00000000528 I 0.846
ENSAMXG00000012247 Astyanax mexicanus ENSAMXG00000012247 I 0.846
AAI66068 Xenopus tropicalis AAI66068 I 0.846
eomesa Tetraodon nigroviridis ENSTNIG00000017582 I 0.846
eomesa Oryzias latipes ENSORLG00000002320 I 0.846
ENSPFOG00000006471 Poecilia formosa ENSPFOG00000006471 I 0.846
eomesa Danio rerio ENSDARG00000006640 I 0.846
Brh_R007719 Buceros rhinoceros Brh_R007719 I 0.843
ENSONIG00000019678 Oreochromis niloticus ENSONIG00000019678 I 0.843
tbx21 Xenopus tropicalis XB-GENE-479103 I 0.843
ENSXMAG00000014284 Xiphophorus maculatus ENSXMAG00000014284 I 0.842
tbr1b Tetraodon nigroviridis ENSTNIG00000016497 I 0.841
ENSP00000388620 Macaca fascicularis ENSP00000388620 I 0.837
tbr1a Danio rerio ENSDARG00000076259 I 0.835
ENSGMOG00000003675 Gadus morhua ENSGMOG00000003675 I 0.825
ENSP00000388620-D1 Bos grunniens ENSP00000388620-D1 I 0.825
ENSPMAG00000003985 Petromyzon marinus ENSPMAG00000003985 I 0.815
Sakowv30002752m.g Saccoglossus kowalevskii Sakowv30002752m.g I 0.815
ENSLACG00000016985 Latimeria chalumnae ENSLACG00000016985 I 0.805
fgenesh2_pg.scaffold_55000054 Branchiostoma floridae fgenesh2_pg.scaffold_55000054 I 0.799
estExt_fgenesh2_kg.C_1840001 Branchiostoma floridae estExt_fgenesh2_kg.C_1840001 I 0.799
A0A075Q982_PATMI Patiria miniata A0A075Q982_PATMI D 0.789
EOMES Ornithorhynchus anatinus ENSOANG00000012619 I 0.783
Tbx21 Rattus norvegicus ENSRNOG00000009427 I 0.770
ENSAMEG00000004661 Ailuropoda melanoleuca ENSAMEG00000004661 I 0.766
TBX21 Canis familiaris ENSCAFG00000016705 I 0.766
ENSP00000177694 Macaca fascicularis ENSP00000177694 I 0.766
Myotis_brandtii_KPNB1_10030428 Myotis brandtii Myotis_brandtii_KPNB1_10030428 I 0.766
LotgiG129911 Lottia gigantea LotgiG129911 I 0.766
ENSNLEG00000001655 Nomascus leucogenys ENSNLEG00000001655 I 0.766
TBX21 Gorilla gorilla ENSGGOG00000002208 I 0.766
ENSPPYG00000008879 Pongo abelii ENSPPYG00000008879 I 0.766
TBX21 Homo sapiens ENSG00000073861 D 0.766
TBX21 Felis catus ENSFCAG00000010607 I 0.766
TBX21 Otolemur garnettii ENSOGAG00000006160 I 0.766
TBX21 Macaca mulatta ENSMMUG00000007098 I 0.766
Tbx21 Mus musculus ENSMUSG00000001444 D 0.766
ENSMPUG00000015272 Mustela putorius furo ENSMPUG00000015272 I 0.766
ENSOARG00000008340 Ovis aries ENSOARG00000008340 I 0.766
TBX21 Oryctolagus cuniculus ENSOCUG00000012907 I 0.766
TBX21 Pteropus vampyrus ENSPVAG00000004921 I 0.766
TBX21 Pan troglodytes ENSPTRG00000009335 I 0.766
ENSSTOG00000001626 Ictidomys tridecemlineatus ENSSTOG00000001626 I 0.766
ENSCSAG00000002587 Chlorocebus sabaeus ENSCSAG00000002587 I 0.766
TBX21 Sus scrofa ENSSSCG00000017517 I 0.766
Tbx21 Dipodomys ordii ENSDORG00000013302 I 0.766
ENSBTAP00000018875-D1 Bos grunniens ENSBTAP00000018875-D1 I 0.763
TBX21 Myotis lucifugus ENSMLUG00000014542 I 0.763
TBX21 Bos taurus ENSBTAG00000014199 I 0.763
SPU_025584 Strongylocentrotus purpuratus SPU_025584 D 0.762
TBX21 Callithrix jacchus ENSCJAG00000007796 I 0.758
CapteG223644 Capitella teleta CapteG223644 I 0.758
EOMES Pteropus vampyrus ENSPVAG00000009999 I 0.752
Pvit_16634 Pogona vitticeps Pvit_16634 I 0.748
ENSCSAG00000009676 Chlorocebus sabaeus ENSCSAG00000009676 I 0.740
TBX21 Cavia porcellus ENSCPOG00000026273 I 0.739
ENSSHAG00000018315 Sarcophilus harrisii ENSSHAG00000018315 I 0.736
ENSMODG00000012526 Monodelphis domestica ENSMODG00000012526 I 0.736
CGI_10020437 Crassostrea gigas CGI_10020437 I 0.734
ENSTTRG00000006645 Tursiops truncatus ENSTTRG00000006645 I 0.667
ENSMEUG00000014480 Macropus eugenii ENSMEUG00000014480 I 0.242
ENSECAG00000002502 Equus caballus ENSECAG00000002502 I 0.156