ENSP00000374205 (Macaca fascicularis)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00907 (T-box) IPR001699 ENSP00000374205 T341072_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbr1
M01028_2.00 		Mus musculus
DTVRCAMNYH
DRNKTGYBAH		 PBM
SebePedros et al.(2013)
pTH2659 		0.920 1.000
TBR1
M03560_2.00 		Homo sapiens
AGGTGTGAAN
NTTCACACCT		 SELEX
Jolma et al.(2013)
TBR1_1 		0.920 1.000
TBR1
M03561_2.00 		Homo sapiens
RAGGTGTGAAH
DTTCACACCTY		 SELEX
Jolma et al.(2013)
TBR1_2 		0.920 1.000
Eomes
M00215_2.00 		Mus musculus
RDGTGYBANN
NNTVRCACHY		 PBM
Badis et al.(2009)
Eomes_0921 		0.865 0.874
EOMES
M03563_2.00 		Homo sapiens
DAGGTGTGAWNNN
NNNWTCACACCTH		 SELEX
Jolma et al.(2013)
EOMES_1 		0.865 0.869
EOMES
M03564_2.00 		Homo sapiens
TVACACNTNNNDRNGTGTGA
TCACACNYHNNNANGTGTBA		 SELEX
Jolma et al.(2013)
EOMES_2 		0.865 0.869
EOMES
M02752_2.00 		Homo sapiens
AGGTGTGAW
WTCACACCT		 SELEX
Jolma et al.(2010)
EOMES_monomer 		0.865 0.869
EOMES
M05807_2.00 		Homo sapiens
DAGGTGTGAN
NTCACACCTH		 SELEX
Yin et al.(2017)
EOMES_eDBD_HT-SELEX 		0.865 0.869
EOMES
M09647_2.00 		Homo sapiens
ARGTGWKAAN
NTTMWCACYT		 Misc
Heinz et al.(2010)
H9-Eomes_GSE26097 		0.865 0.869
EOMES
M05808_2.00 		Homo sapiens
NABGTGYKAH
DTMRCACVTN		 SELEX
Yin et al.(2017)
EOMES_eDBD_Methyl-HT-SELEX 		0.865 0.869
A0A075Q982_PATMI
M00734_2.00 		Patiria miniata
NAGGTGTBAN
NTVACACCTN		 PBM
Cheatle-Jarvela et al.(2014)
PmTbr 		0.789 0.645
TBX21
M03546_2.00 		Homo sapiens
GGTGTGAHDTMACACY
RGTGTKAHDTCACACC		 SELEX
Jolma et al.(2013)
TBX21_1 		0.766 0.732
TBX21
M03547_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_2 		0.766 0.732
TBX21
M03548_2.00 		Homo sapiens
TMACACYTNNDAGGTGTGA
TCACACCTHNNARGTGTKA		 SELEX
Jolma et al.(2013)
TBX21_3 		0.766 0.732
TBX21
M03549_2.00 		Homo sapiens
GGTGTGAWATCACACC
GGTGTGATWTCACACC		 SELEX
Jolma et al.(2013)
TBX21_4 		0.766 0.732
TBX21
M03550_2.00 		Homo sapiens
DAGGTGTGAW
WTCACACCTH		 SELEX
Jolma et al.(2013)
TBX21_5 		0.766 0.732
TBX21
M03551_2.00 		Homo sapiens
TSACACCWNMRAGGTGTGA
TCACACCTYKNWGGTGTSA		 SELEX
Jolma et al.(2013)
TBX21_6 		0.766 0.732
TBX21
M05793_2.00 		Homo sapiens
DAGGTGTKAN
NTMACACCTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_HT-SELEX 		0.766 0.732
TBX21
M09425_2.00 		Homo sapiens
NDSDRGSTGWBRN
NYVWCASCYHSHN		 Misc
Kulakovskiy et al.(2013)
TBX21_HUMAN.H11MO.0.A 		0.766 0.732
Tbx21
M09428_2.00 		Mus musculus
DNDDSTGWSDND
HNHSWCASHHNH		 Misc
Kulakovskiy et al.(2013)
TBX21_MOUSE.H11MO.0.A 		0.766 0.732
Tbx21
M09648_2.00 		Mus musculus
ADGTGWSAHN
NDTSWCACHT		 Misc
Heinz et al.(2010)
CD8-Tbet_GSE33802 		0.766 0.732
TBX21
M05794_2.00 		Homo sapiens
DASGTGTKAW
WTMACACSTH		 SELEX
Yin et al.(2017)
TBX21_eDBD_Methyl-HT-SELEX 		0.766 0.732
SPU_025584
M00733_2.00 		Strongylocentrotus purpuratus
RGGTGTGANN
NNTCACACCY		 PBM
Cheatle-Jarvela et al.(2014)
SpTbr 		0.762 0.617
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000374205 T-box 206 393

Links

Other T-box family TFs
Other Macaca fascicularis TFs

Invalid Input OrderBy

166 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action