TEAD4 (Homo sapiens)
TEA

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01285 (TEA) IPR000818 ENSG00000197905 T346531_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TEAD4
M03579_2.00		 Homo sapiens
NHRGAATKYN
NRMATTCYDN		 SELEX
Jolma et al.(2013)
TEAD4_1		 (Direct) (Direct)
TEAD4
M09435_2.00		 Homo sapiens
NDBNNWGGAATKY
RMATTCCWNNVHN		 Misc
Kulakovskiy et al.(2013)
TEAD4_HUMAN.H11MO.0.A		 (Direct) (Direct)
TEAD4
M11409_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF3_Q3		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TEAD1
M03577_2.00 		Homo sapiens
DHGGAATGYN
NRCATTCCDH		 SELEX
Jolma et al.(2013)
TEAD1_1 		0.818 0.818
ENSTNIG00000008857_CONSTRUCT
M01323_2.00 		PBM CONSTRUCTS
NRGWATKYN
NRMATWCYN		 PBM
Lambert et al.(2019)
pTH9815 		0.708 0.708
TEAD1
M03578_2.00 		Homo sapiens
HGGWATKYNHGGAATGY
RCATTCCDNRMATWCCD		 SELEX
Jolma et al.(2013)
TEAD1_2 		0.818 0.818
Tead1
M09438_2.00 		Mus musculus
BSYWGGAATGY
RCATTCCWRSV		 Misc
Kulakovskiy et al.(2013)
TEAD1_MOUSE.H11MO.0.A 		0.963 0.963
TEAD1
M05825_2.00 		Homo sapiens
HGGWATGYN
NRCATWCCD		 SELEX
Yin et al.(2017)
TEAD1_FL_HT-SELEX 		0.818 0.818
TEAD1
M09434_2.00 		Homo sapiens
DBBNWGGAATGY
RCATTCCWNVVH		 Misc
Kulakovskiy et al.(2013)
TEAD1_HUMAN.H11MO.0.A 		0.818 0.818
TEAD1
M11404_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF_01 		0.818 0.818
TEAD1
M11405_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF_07 		0.818 0.818
TEAD1
M11406_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF1_Q6_03 		0.818 0.818
TEAD1
M11407_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF1_Q6_04 		0.818 0.818
TEAD1
M11408_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF1_Q6 		0.818 0.818
TEAD1
M05826_2.00 		Homo sapiens
HGGWATGYN
NRCATWCCD		 SELEX
Yin et al.(2017)
TEAD1_FL_Methyl-HT-SELEX 		0.939 0.939
TEAD3
M03575_2.00 		Homo sapiens
HGGWATGHNHRGAATGY
RCATTCYDNDCATWCCD		 SELEX
Jolma et al.(2013)
TEAD3_1 		0.890 0.890
TEAD3
M03576_2.00 		Homo sapiens
HGGAATGY
RCATTCCD		 SELEX
Jolma et al.(2013)
TEAD3_2 		0.890 0.890
TEAD3
M11401_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF5_Q2 		0.890 0.890
TEAD3
M11402_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF5_Q6_01 		0.890 0.890
sd
M03995_2.00 		Drosophila melanogaster
HGGAATGYRN
NYRCATTCCD		 SELEX
Nitta et al.(2015)
sd_1 		0.841 0.841
Tead4
M09436_2.00 		Mus musculus
VNRHBHNWGGAATKY
RMATTCCWNDVDYNB		 Misc
Kulakovskiy et al.(2013)
TEAD4_MOUSE.H11MO.0.A 		0.812 0.812
sd
M03996_2.00 		Drosophila melanogaster
DDWGGAATGYRN
NYRCATTCCWHH		 SELEX
Nitta et al.(2015)
sd_2 		0.841 0.841
Tead4
M09652_2.00 		Mus musculus
NNNGGAATBY
RVATTCCNNN		 Misc
Heinz et al.(2010)
Tropoblast-Tead4_GSE37350 		0.812 0.812
sd
M06455_2.00 		Drosophila melanogaster
NYBHNRWATKWH
DWMATWYNDVRN		 B1H
Zhu et al.(2011)
sd_FlyReg_FBgn0003345 		0.841 0.841
TEAD2
M05823_2.00 		Homo sapiens
NWGGAATGYR
YRCATTCCWN		 SELEX
Yin et al.(2017)
TEAD2_FL_HT-SELEX 		0.771 0.771
sd
M07545_2.00 		Drosophila melanogaster
NYBHNRWATKWH
DWMATWYNDVRN		 DNaseI footprinting
Mathelier et al.(2014)
MA0243.1 		0.841 0.841
TEAD2
M08175_2.00 		Homo sapiens
NNNWGGAATGTNN
NNACATTCCWNNN		 ChIP-seq
Mathelier et al.(2014)
MA1121.1 		0.771 0.771
Tead2
M09437_2.00 		Mus musculus
SCWGGAATGYNN
NNRCATTCCWGS		 Misc
Kulakovskiy et al.(2013)
TEAD2_MOUSE.H11MO.0.C 		0.771 0.771
Tead2
M09653_2.00 		Mus musculus
BCWGGAATGY
RCATTCCWGV		 Misc
Heinz et al.(2010)
Py2T-Tead2_GSE55709 		0.771 0.771
sd
M11410_2.00 		Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$SD_Q6 		0.841 0.841
TEAD2
M11403_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ETF_Q6_01 		0.771 0.771
TEAD2
M05824_2.00 		Homo sapiens
NHGGAATGYR
YRCATTCCDN		 SELEX
Yin et al.(2017)
TEAD2_FL_Methyl-HT-SELEX 		0.771 0.771
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000351184 TEA 31 114
ENSP00000352926 TEA 31 155
ENSP00000411475 TEA 29 78
ENSP00000438453 TEA 28 71
ENSP00000441959 TEA 1 23
ENSP00000444528 TEA 30 152

Links

Other TEA family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

322 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action