sd (Drosophila melanogaster)
TEA

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01285 (TEA) IPR000818 FBgn0003345 T346700_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coregulator binding activity. Involved in several processes, including animal organ development; negative regulation of neuroblast proliferation; and regulation of transcription, DNA-templated. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including extended germ band embryo; head segment; nervous system; somatic muscle cell; and thorax. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD3 (TEA domain transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
sd
M03995_2.00		 Drosophila melanogaster
HGGAATGYRN
NYRCATTCCD		 SELEX
Nitta et al.(2015)
sd_1		 (Direct) (Direct)
sd
M03996_2.00		 Drosophila melanogaster
DDWGGAATGYRN
NYRCATTCCWHH		 SELEX
Nitta et al.(2015)
sd_2		 (Direct) (Direct)
sd
M06455_2.00		 Drosophila melanogaster
NYBHNRWATKWH
DWMATWYNDVRN		 B1H
Zhu et al.(2011)
sd_FlyReg_FBgn0003345		 (Direct) (Direct)
sd
M07545_2.00		 Drosophila melanogaster
NYBHNRWATKWH
DWMATWYNDVRN		 DNaseI footprinting
Mathelier et al.(2014)
MA0243.1		 (Direct) (Direct)
sd
M11410_2.00		 Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$SD_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TEAD1
M03577_2.00 		Homo sapiens
DHGGAATGYN
NRCATTCCDH		 SELEX
Jolma et al.(2013)
TEAD1_1 		0.700 0.700
TEAD1
M03578_2.00 		Homo sapiens
HGGWATKYNHGGAATGY
RCATTCCDNRMATWCCD		 SELEX
Jolma et al.(2013)
TEAD1_2 		0.700 0.700
TEAD1
M05825_2.00 		Homo sapiens
HGGWATGYN
NRCATWCCD		 SELEX
Yin et al.(2017)
TEAD1_FL_HT-SELEX 		0.700 0.700
TEAD1
M09434_2.00 		Homo sapiens
DBBNWGGAATGY
RCATTCCWNVVH		 Misc
Kulakovskiy et al.(2013)
TEAD1_HUMAN.H11MO.0.A 		0.700 0.700
TEAD1
M11404_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF_01 		0.700 0.700
TEAD1
M11405_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF_07 		0.700 0.700
TEAD1
M11406_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF1_Q6_03 		0.717 0.717
TEAD1
M11407_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF1_Q6_04 		0.717 0.717
TEAD1
M11408_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF1_Q6 		0.700 0.700
TEAD1
M05826_2.00 		Homo sapiens
HGGWATGYN
NRCATWCCD		 SELEX
Yin et al.(2017)
TEAD1_FL_Methyl-HT-SELEX 		0.700 0.700
Tead1
M09438_2.00 		Mus musculus
BSYWGGAATGY
RCATTCCWRSV		 Misc
Kulakovskiy et al.(2013)
TEAD1_MOUSE.H11MO.0.A 		0.707 0.707
Tead2
M09437_2.00 		Mus musculus
SCWGGAATGYNN
NNRCATTCCWGS		 Misc
Kulakovskiy et al.(2013)
TEAD2_MOUSE.H11MO.0.C 		0.775 0.775
TEAD4
M03579_2.00 		Homo sapiens
NHRGAATKYN
NRMATTCYDN		 SELEX
Jolma et al.(2013)
TEAD4_1 		0.784 0.784
Tead2
M09653_2.00 		Mus musculus
BCWGGAATGY
RCATTCCWGV		 Misc
Heinz et al.(2010)
Py2T-Tead2_GSE55709 		0.775 0.775
TEAD4
M09435_2.00 		Homo sapiens
NDBNNWGGAATKY
RMATTCCWNNVHN		 Misc
Kulakovskiy et al.(2013)
TEAD4_HUMAN.H11MO.0.A 		0.784 0.784
TEAD2
M05823_2.00 		Homo sapiens
NWGGAATGYR
YRCATTCCWN		 SELEX
Yin et al.(2017)
TEAD2_FL_HT-SELEX 		0.764 0.764
TEAD2
M08175_2.00 		Homo sapiens
NNNWGGAATGTNN
NNACATTCCWNNN		 ChIP-seq
Mathelier et al.(2014)
MA1121.1 		0.764 0.764
TEAD4
M11409_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF3_Q3 		0.784 0.784
TEAD2
M11403_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ETF_Q6_01 		0.764 0.764
TEAD2
M05824_2.00 		Homo sapiens
NHGGAATGYR
YRCATTCCDN		 SELEX
Yin et al.(2017)
TEAD2_FL_Methyl-HT-SELEX 		0.764 0.764
TEAD3
M03575_2.00 		Homo sapiens
HGGWATGHNHRGAATGY
RCATTCYDNDCATWCCD		 SELEX
Jolma et al.(2013)
TEAD3_1 		0.753 0.753
TEAD3
M03576_2.00 		Homo sapiens
HGGAATGY
RCATTCCD		 SELEX
Jolma et al.(2013)
TEAD3_2 		0.753 0.753
TEAD3
M11401_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF5_Q2 		0.753 0.753
TEAD3
M11402_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF5_Q6_01 		0.753 0.753
ENSTNIG00000008857_CONSTRUCT
M01323_2.00 		PBM CONSTRUCTS
NRGWATKYN
NRMATWCYN		 PBM
Lambert et al.(2019)
pTH9815 		0.730 0.730
Tead4
M09436_2.00 		Mus musculus
VNRHBHNWGGAATKY
RMATTCCWNDVDYNB		 Misc
Kulakovskiy et al.(2013)
TEAD4_MOUSE.H11MO.0.A 		0.705 0.705
Tead4
M09652_2.00 		Mus musculus
NNNGGAATBY
RVATTCCNNN		 Misc
Heinz et al.(2010)
Tropoblast-Tead4_GSE37350 		0.705 0.705
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0073914 TEA 59 159
FBpp0073915 TEA 5 96
FBpp0089157 TEA 5 96
FBpp0111736 TEA 34 136
FBpp0111737 TEA 59 159
FBpp0111738 TEA 59 159
FBpp0111739 TEA 59 159
FBpp0290758 TEA 59 161
FBpp0290759 TEA 59 161
FBpp0300450 TEA 34 136
FBpp0300451 TEA 59 159
FBpp0300452 TEA 5 96
FBpp0300453 TEA 59 161
FBpp0300454 TEA 5 96
FBpp0300455 TEA 34 136
FBpp0300456 TEA 34 136
FBpp0301994 TEA 5 96
FBpp0301995 TEA 59 159
FBpp0301996 TEA 59 159
FBpp0309110 TEA 5 94
FBpp0312377 TEA 34 136

Links

Other TEA family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

226 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action