THAP1 (Homo sapiens)
THAP finger

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF05485 (THAP) IPR006612 ENSG00000131931 T348348_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
THAP1
M08020_2.00		 Homo sapiens
SGCCATBTTKRNWVHGGGCRR
YYGCCCDBWNYMAAVATGGCS		 ChIP-seq
Gerstein et al.(2012)
K562_THAP1_HudsonAlpha		 (Direct) (Direct)
THAP1
M08176_2.00		 Homo sapiens
DNHKGGMRR
YYKCCMDNH		 ChIP-seq
Mathelier et al.(2014)
MA0597.1		 (Direct) (Direct)
THAP1
M09439_2.00		 Homo sapiens
GCCCDVVNBVRVSVKGGCBSCB
VGSVGCCMBSBYBVNBBHGGGC		 Misc
Kulakovskiy et al.(2013)
THAP1_HUMAN.H11MO.0.C		 (Direct) (Direct)
THAP1
M11412_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_01		 (Direct) (Direct)
THAP1
M11413_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_02		 (Direct) (Direct)
THAP1
M11414_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_04		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000254250 THAP finger 4 83
ENSP00000433912 THAP finger 4 83

Links

Other THAP finger family TFs
Other Homo sapiens TFs

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57 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action