Thap1 (Rattus norvegicus)
THAP finger

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF05485 (THAP) IPR006612 ENSRNOG00000056956 T348683_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including endothelial cell proliferation; negative regulation of transcription by RNA polymerase II; and transcription, DNA-templated. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in torsion dystonia 6. Orthologous to human THAP1 (THAP domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
THAP1
M08176_2.00 		Homo sapiens
DNHKGGMRR
YYKCCMDNH		 ChIP-seq
Mathelier et al.(2014)
MA0597.1 		0.987 0.987
THAP1
M08020_2.00 		Homo sapiens
SGCCATBTTKRNWVHGGGCRR
YYGCCCDBWNYMAAVATGGCS		 ChIP-seq
Gerstein et al.(2012)
K562_THAP1_HudsonAlpha 		0.987 0.987
THAP1
M09439_2.00 		Homo sapiens
GCCCDVVNBVRVSVKGGCBSCB
VGSVGCCMBSBYBVNBBHGGGC		 Misc
Kulakovskiy et al.(2013)
THAP1_HUMAN.H11MO.0.C 		0.987 0.987
THAP1
M11412_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_01 		0.987 0.987
THAP1
M11413_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_02 		0.987 0.987
THAP1
M11414_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_04 		0.987 0.987
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000071777 THAP finger 4 83

Links

Other THAP finger family TFs
Other Rattus norvegicus TFs

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58 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action