ENSBTAP00000008406-D1 (Bos grunniens)
THAP finger

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF05485 (THAP) IPR006612 ENSBTAP00000008406-D1 T349334_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
THAP11
M09440_2.00
Homo sapiens
KGCMTBCTGGGARWTGTAGTYY

RRACTACAWYTCCCAGVAKGCM
Misc
Kulakovskiy et al.(2013)
THA11_HUMAN.H11MO.0.B
1.000 1.000
Thap11
M09441_2.00
Mus musculus
KGCMTBCTGGGARWTGTAGTYY

RRACTACAWYTCCCAGVAKGCM
Misc
Kulakovskiy et al.(2013)
THA11_MOUSE.H11MO.0.B
1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSBTAP00000008406-D1 THAP finger 5 123

Links

Other THAP finger family TFs
Other Bos grunniens TFs

44 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSOARG00000010537 Ovis aries ENSOARG00000010537 I 1.000
THAP11 Oryctolagus cuniculus ENSOCUG00000009342 I 1.000
THAP11 Otolemur garnettii ENSOGAG00000034339 I 1.000
THAP11 Ornithorhynchus anatinus ENSOANG00000006140 I 1.000
Thap11 Mus musculus ENSMUSG00000036442 D 1.000
THAP11 Macaca mulatta ENSMMUG00000013240 I 1.000
THAP11 Monodelphis domestica ENSMODG00000005522 I 1.000
ENSPANG00000011972 Papio anubis ENSPANG00000011972 I 1.000
ENSPPYG00000007471 Pongo abelii ENSPPYG00000007471 I 1.000
THAP11 Sus scrofa ENSSSCG00000002769 I 1.000
ENSSTOG00000021807 Ictidomys tridecemlineatus ENSSTOG00000021807 I 1.000
Myotis_brandtii_Thap11_10015084 Myotis brandtii Myotis_brandtii_Thap11_10015084 I 1.000
THAP11 Sorex araneus ENSSARG00000013268 I 1.000
Thap11 Rattus norvegicus ENSRNOG00000019109 I 1.000
THAP11 Pan troglodytes ENSPTRG00000008247 I 1.000
THAP11 Pteropus vampyrus ENSPVAG00000016604 I 1.000
THAP11 Myotis lucifugus ENSMLUG00000005845 I 1.000
ENSMPUG00000019895 Mustela putorius furo ENSMPUG00000019895 I 1.000
THAP11 Homo sapiens ENSG00000168286 D 1.000
THAP11 Felis catus ENSFCAG00000012850 I 1.000
ENSCSAG00000018473 Chlorocebus sabaeus ENSCSAG00000018473 I 1.000
THAP11 Dasypus novemcinctus ENSDNOG00000009718 I 1.000
THAP11 Cavia porcellus ENSCPOG00000001016 I 1.000
THAP11 Gorilla gorilla ENSGGOG00000013846 I 1.000
THAP11 Bos taurus ENSBTAG00000006411 I 1.000
THAP11 Canis familiaris ENSCAFG00000020344 I 1.000
THAP11 Choloepus hoffmanni ENSCHOG00000008297 I 1.000
ENSAMEG00000017547 Ailuropoda melanoleuca ENSAMEG00000017547 I 1.000
Pvit_14747 Pogona vitticeps Pvit_14747 I 0.930
THAP11 Anolis carolinensis ENSACAG00000001520 I 0.930
ENSFALG00000007023 Ficedula albicollis ENSFALG00000007023 I 0.930
THAP11 Microcebus murinus ENSMICG00000012247 I 0.873
ENSLACG00000016376 Latimeria chalumnae ENSLACG00000016376 I 0.845
thap11.L Xenopus laevis XB-GENE-5954813 I 0.845
thap11 Xenopus tropicalis XB-GENE-5954792 I 0.845
ENSAMXG00000025848 Astyanax mexicanus ENSAMXG00000025848 I 0.817
ENSXMAG00000019795 Xiphophorus maculatus ENSXMAG00000019795 I 0.817
ENSPFOG00000020599 Poecilia formosa ENSPFOG00000020599 I 0.817
thap11 Danio rerio ENSDARG00000036055 I 0.817
thap11 Gasterosteus aculeatus ENSGACG00000015879 I 0.803
thap11 Oryzias latipes ENSORLG00000008903 I 0.803
ENSLOCG00000017596 Lepisosteus oculatus ENSLOCG00000017596 I 0.789
thap11 Tetraodon nigroviridis ENSTNIG00000009306 I 0.789
ENSONIG00000021394 Oreochromis niloticus ENSONIG00000021394 I 0.789