CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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LYS14
(
Saccharomyces cerevisiae
)
Zinc cluster
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00172 (Zn_clus)
IPR001138
YDR034C
T388338_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables RNA polymerase II complex binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone binding activity. Involved in several processes, including chromosome organization; regulation of cell cycle process; and regulation of nucleobase-containing compound metabolic process. Located in cellular bud neck; endoplasmic reticulum; and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Used to study cancer. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; prostate cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to several human genes including CDK1 (cyclin dependent kinase 1) and CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
LYS14
M00080_2.00
Saccharomyces cerevisiae
NNNNGVDWHN
NDWHBCNNNN
PBM
Badis et al.(2008)
LYS14_2065
(Direct)
(Direct)
LYS14
M01574_2.00
Saccharomyces cerevisiae
NNGGRAWNN
NNWTYCCNN
PBM
Zhu et al.(2009)
Lys14
(Direct)
(Direct)
LYS14
M07507_2.00
Saccharomyces cerevisiae
VCGGAATT
AATTCCGB
PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0325.1
(Direct)
(Direct)
LYS14
M08651_2.00
Saccharomyces cerevisiae
WWTTCCRVYGGRAWH
DWTYCCRBYGGAAWW
Misc
DeBoer et al.(2011)
YDR034C_133
(Direct)
(Direct)
LYS14
M08652_2.00
Saccharomyces cerevisiae
DNNVHVCGGAATTTNKNNNN
NNNNMNAAATTCCGBDBNNH
Misc
DeBoer et al.(2011)
YDR034C_865
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.537
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00080_2.00
Zinc cluster
51
90
NGCSECKRRRMKCDETKPTCWQCARLNRQCVYVLNPKNKK
M01574_2.00
Zinc cluster
157
196
NGCSECKRRRMKCDETKPTCWQCARLNRQCVYVLNPKNKK
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
YDR034C
Zinc cluster
157
196
NGCSECKRRRMKCDETKPTCWQCARLNRQCVYVLNPKNKK
Links
Other
Zinc cluster
family TFs
Other
Saccharomyces cerevisiae
TFs
19 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy