SIX6 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000184302 T209927_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SIX6
M00325_2.00
Homo sapiens
NNNDATMB

VKATHNNN
PBM
Barrera et al.(2016)
SIX6_H141N
(Direct) (Direct)
SIX6
M00326_2.00
Homo sapiens
NNDATMB

VKATHNN
PBM
Barrera et al.(2016)
SIX6_REF
(Direct) (Direct)
SIX6
M00327_2.00
Homo sapiens
NHDAYMBNN

NNVKRTHDN
PBM
Barrera et al.(2016)
SIX6_T165A
(Direct) (Direct)
SIX6
M05357_2.00
Homo sapiens
NNYGATASVB

VBSTATCRNN
SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX
(Direct) (Direct)
SIX6
M05358_2.00
Homo sapiens
VBVYAYCRNN

NNYGRTRBVB
SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Six6
M00169_2.00
Mus musculus
NNAYMNN

NNKRTNN
PBM
Badis et al.(2009)
Six6_2267
0.867 1.000
Six6
M00412_2.00
Mus musculus
NNNTGATAYCN

NGRTATCANNN
PBM
Berger et al.(2008)
Six6_2267
0.867 1.000
Six3
M00483_2.00
Mus musculus
NNNAYMN

NKRTNNN
PBM
Berger et al.(2008)
Six3_1732
0.865 0.982
SIX3
M05159_2.00
Homo sapiens
NNYGATABBN

NVVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX
0.865 0.982
SIX3
M10698_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SIX3_Q6
0.865 0.982
SIX3
M05160_2.00
Homo sapiens
NNYGATABVB

VBVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX
0.865 0.982
six3
M02102_2.00
Oryzias latipes
NNDAYMBNNN

NNNVKRTHNN
PBM
Weirauch et al.(2014)
pTH5928
0.865 0.947
Optix
M02124_2.00
Drosophila melanogaster
NNNNNDATMN

NKATHNNNNN
PBM
Weirauch et al.(2014)
pTH5437
0.865 0.930
Optix
M03850_2.00
Drosophila melanogaster
TAATYTAATTA

TAATTARATTA
SELEX
Nitta et al.(2015)
Optix_1
0.865 0.930
Optix
M06526_2.00
Drosophila melanogaster
TGATA

TATCA
B1H
Mathelier et al.(2014)
MA0199.1
0.865 0.930
Optix
M06327_2.00
Drosophila melanogaster
HHVTGATA

TATCABDD
B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360
0.865 0.930
Optix
M06328_2.00
Drosophila melanogaster
NNNTGATA

TATCANNN
B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360
0.865 0.930
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00325_2.00 Homeodomain 11 67
M00326_2.00 Homeodomain 11 67
M00327_2.00 Homeodomain 11 67

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000328596 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

296 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000007611 Ailuropoda melanoleuca ENSAMEG00000007611 I
ENSBTAG00000043974 Bos taurus ENSBTAG00000043974 I
ZNF768 Canis familiaris ENSCAFG00000029911 I
ZNF768 Cavia porcellus ENSCPOG00000005238 I
ENSCSAG00000005878 Chlorocebus sabaeus ENSCSAG00000005878 I
ZNF768 Dasypus novemcinctus ENSDNOG00000017198 I
Zfp768 Dipodomys ordii ENSDORG00000009870 I
ZNF768 Equus caballus ENSECAG00000008014 I
ZNF768 Felis catus ENSFCAG00000009798 I
ZNF768 Homo sapiens ENSG00000169957 D
ZNF768 Gorilla gorilla ENSGGOG00000002196 I
ENSLAFG00000031653 Loxodonta africana ENSLAFG00000031653 I
ENSMEUG00000000503 Macropus eugenii ENSMEUG00000000503 I
ZNF768 Macaca mulatta ENSMMUG00000016879 I
ZNF768 Monodelphis domestica ENSMODG00000027841 I
Zfp768 Mus musculus ENSMUSG00000047371 I
ENSNLEG00000015875 Nomascus leucogenys ENSNLEG00000015875 I
ENSOARG00000010779 Ovis aries ENSOARG00000010779 I
ZNF768 Otolemur garnettii ENSOGAG00000033980 I
ENSP00000369777 Macaca fascicularis ENSP00000369777 I
ENSPANG00000016539 Papio anubis ENSPANG00000016539 I
ENSPPYG00000007277 Pongo abelii ENSPPYG00000007277 I
ZNF768 Pteropus vampyrus ENSPVAG00000010064 I
Znf768 Rattus norvegicus ENSRNOG00000029490 I
ENSSHAG00000008255 Sarcophilus harrisii ENSSHAG00000008255 I
ZNF768 Sus scrofa ENSSSCG00000023349 I
ZNF768 Tupaia belangeri ENSTBEG00000004851 I
ZNF768 Tursiops truncatus ENSTTRG00000001737 I
ZNF768 Vicugna pacos ENSVPAG00000010456 I
Myotis_brandtii_ZNF768_10014481 Myotis brandtii Myotis_brandtii_ZNF768_10014481 I