CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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SIX6
(
Homo sapiens
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSG00000184302
T209927_2.00
Ensembl (2018-Dec-8)
Link out
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
SIX6
M00325_2.00
Homo sapiens
NNNDATMB
VKATHNNN
PBM
Barrera et al.(2016)
SIX6_H141N
(Direct)
(Direct)
SIX6
M00326_2.00
Homo sapiens
NNDATMB
VKATHNN
PBM
Barrera et al.(2016)
SIX6_REF
(Direct)
(Direct)
SIX6
M00327_2.00
Homo sapiens
NHDAYMBNN
NNVKRTHDN
PBM
Barrera et al.(2016)
SIX6_T165A
(Direct)
(Direct)
SIX6
M05357_2.00
Homo sapiens
NNYGATASVB
VBSTATCRNN
SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX
(Direct)
(Direct)
SIX6
M05358_2.00
Homo sapiens
VBVYAYCRNN
NNYGRTRBVB
SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Six6
M00169_2.00
Mus musculus
NNAYMNN
NNKRTNN
PBM
Badis et al.(2009)
Six6_2267
0.867
1.000
Six6
M00412_2.00
Mus musculus
NNNTGATAYCN
NGRTATCANNN
PBM
Berger et al.(2008)
Six6_2267
0.867
1.000
Six3
M00483_2.00
Mus musculus
NNNAYMN
NKRTNNN
PBM
Berger et al.(2008)
Six3_1732
0.865
0.982
SIX3
M05159_2.00
Homo sapiens
NNYGATABBN
NVVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX
0.865
0.982
SIX3
M10698_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SIX3_Q6
0.865
0.982
SIX3
M05160_2.00
Homo sapiens
NNYGATABVB
VBVTATCRNN
SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX
0.865
0.982
six3
M02102_2.00
Oryzias latipes
NNDAYMBNNN
NNNVKRTHNN
PBM
Weirauch et al.(2014)
pTH5928
0.865
0.947
Optix
M02124_2.00
Drosophila melanogaster
NNNNNDATMN
NKATHNNNNN
PBM
Weirauch et al.(2014)
pTH5437
0.865
0.930
Optix
M03850_2.00
Drosophila melanogaster
TAATYTAATTA
TAATTARATTA
SELEX
Nitta et al.(2015)
Optix_1
0.865
0.930
Optix
M06526_2.00
Drosophila melanogaster
TGATA
TATCA
B1H
Mathelier et al.(2014)
MA0199.1
0.865
0.930
Optix
M06327_2.00
Drosophila melanogaster
HHVTGATA
TATCABDD
B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360
0.865
0.930
Optix
M06328_2.00
Drosophila melanogaster
NNNTGATA
TATCANNN
B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360
0.865
0.930
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00325_2.00
Homeodomain
11
67
EQKTHCFKERTRNLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
M00326_2.00
Homeodomain
11
67
EQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
M00327_2.00
Homeodomain
11
67
EQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQAAGLTPTQVGNWFKNRRQRDRA
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000328596
Homeodomain
129
185
EQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRA
Links
Other
Homeodomain
family TFs
Other
Homo sapiens
TFs
296 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
ENSAMEG00000007611
Ailuropoda melanoleuca
ENSAMEG00000007611
I
ENSBTAG00000043974
Bos taurus
ENSBTAG00000043974
I
ZNF768
Canis familiaris
ENSCAFG00000029911
I
ZNF768
Cavia porcellus
ENSCPOG00000005238
I
ENSCSAG00000005878
Chlorocebus sabaeus
ENSCSAG00000005878
I
ZNF768
Dasypus novemcinctus
ENSDNOG00000017198
I
Zfp768
Dipodomys ordii
ENSDORG00000009870
I
ZNF768
Equus caballus
ENSECAG00000008014
I
ZNF768
Felis catus
ENSFCAG00000009798
I
ZNF768
Homo sapiens
ENSG00000169957
D
ZNF768
Gorilla gorilla
ENSGGOG00000002196
I
ENSLAFG00000031653
Loxodonta africana
ENSLAFG00000031653
I
ENSMEUG00000000503
Macropus eugenii
ENSMEUG00000000503
I
ZNF768
Macaca mulatta
ENSMMUG00000016879
I
ZNF768
Monodelphis domestica
ENSMODG00000027841
I
Zfp768
Mus musculus
ENSMUSG00000047371
I
ENSNLEG00000015875
Nomascus leucogenys
ENSNLEG00000015875
I
ENSOARG00000010779
Ovis aries
ENSOARG00000010779
I
ZNF768
Otolemur garnettii
ENSOGAG00000033980
I
ENSP00000369777
Macaca fascicularis
ENSP00000369777
I
ENSPANG00000016539
Papio anubis
ENSPANG00000016539
I
ENSPPYG00000007277
Pongo abelii
ENSPPYG00000007277
I
ZNF768
Pteropus vampyrus
ENSPVAG00000010064
I
Znf768
Rattus norvegicus
ENSRNOG00000029490
I
ENSSHAG00000008255
Sarcophilus harrisii
ENSSHAG00000008255
I
ZNF768
Sus scrofa
ENSSSCG00000023349
I
ZNF768
Tupaia belangeri
ENSTBEG00000004851
I
ZNF768
Tursiops truncatus
ENSTTRG00000001737
I
ZNF768
Vicugna pacos
ENSVPAG00000010456
I
Myotis_brandtii_ZNF768_10014481
Myotis brandtii
Myotis_brandtii_ZNF768_10014481
I