Six2 (Mus musculus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSMUSG00000024134 T212432_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Six2
M00425_2.00		 Mus musculus
NNAYMYNN
NNRKRTNN		 PBM
Berger et al.(2008)
Six2_2307		 (Direct) (Direct)
Six2
M09185_2.00		 Mus musculus
DGWAAYHYRABMYB
VRKVTYRDRTTWCH		 Misc
Kulakovskiy et al.(2013)
SIX2_MOUSE.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SIX2
M05285_2.00 		Homo sapiens
NNYGATACSB
VSGTATCRNN		 SELEX
Yin et al.(2017)
SIX2_eDBD_HT-SELEX 		0.867 1.000
SIX2
M05287_2.00 		Homo sapiens
NSGTRWCRYN
NRYGWYACSN		 SELEX
Yin et al.(2017)
SIX2_FL_HT-SELEX 		0.867 1.000
SIX2
M08133_2.00 		Homo sapiens
NNNTGWAACCTGAKMH
DKMTCAGGTTWCANNN		 ChIP-seq
Mathelier et al.(2014)
MA1119.1 		0.867 1.000
SIX2
M09157_2.00 		Homo sapiens
DGWAAYHHGABMH
DKVTCDDRTTWCH		 Misc
Kulakovskiy et al.(2013)
SIX2_HUMAN.H11MO.0.A 		0.867 1.000
SIX2
M05286_2.00 		Homo sapiens
NBRTATCRNN
NNYGATAYVN		 SELEX
Yin et al.(2017)
SIX2_eDBD_Methyl-HT-SELEX 		0.867 1.000
SIX2
M05288_2.00 		Homo sapiens
VBRTAWCRNN
NNYGWTAYVB		 SELEX
Yin et al.(2017)
SIX2_FL_Methyl-HT-SELEX 		0.867 1.000
so
M02117_2.00 		Drosophila melanogaster
NDATMYNNN
NNNRKATHN		 PBM
Weirauch et al.(2014)
pTH5690 		0.866 0.945
so
M03800_2.00 		Drosophila melanogaster
NYGATAYB
VRTATCRN		 SELEX
Nitta et al.(2015)
so_1 		0.866 0.945
so
M03801_2.00 		Drosophila melanogaster
YKATAYNNNYGATAY
RTATCRNNNRTATMR		 SELEX
Nitta et al.(2015)
so_2 		0.866 0.945
so
M03802_2.00 		Drosophila melanogaster
YGATACGTATCR
YGATACGTATCR		 SELEX
Nitta et al.(2015)
so_3 		0.866 0.945
so
M03803_2.00 		Drosophila melanogaster
RTATCRYGATAC
GTATCRYGATAY		 SELEX
Nitta et al.(2015)
so_4 		0.866 0.945
so
M06497_2.00 		Drosophila melanogaster
TGATAC
GTATCA		 B1H
Mathelier et al.(2014)
MA0246.1 		0.866 0.945
so
M06268_2.00 		Drosophila melanogaster
NRTGATA
TATCAYN		 B1H
Zhu et al.(2011)
So_Cell_FBgn0003460 		0.866 0.945
so
M06269_2.00 		Drosophila melanogaster
NNNTGATA
TATCANNN		 B1H
Zhu et al.(2011)
So_SOLEXA_FBgn0003460 		0.866 0.945
Six1
M00512_2.00 		Mus musculus
NNDATMYNNN
NNNRKATHNN		 PBM
Berger et al.(2008)
Six1_0935 		0.865 0.982
SIX1
M05094_2.00 		Homo sapiens
NNYGATACVB
VBGTATCRNN		 SELEX
Yin et al.(2017)
SIX1_eDBD_HT-SELEX 		0.865 0.982
SIX1
M05096_2.00 		Homo sapiens
NNYGATAYVB
VBRTATCRNN		 SELEX
Yin et al.(2017)
SIX1_FL_HT-SELEX 		0.865 0.982
SIX1
M08130_2.00 		Homo sapiens
GWAACCTGANM
KNTCAGGTTWC		 ChIP-seq
Mathelier et al.(2014)
MA1118.1 		0.865 0.982
SIX1
M09142_2.00 		Homo sapiens
DGWAAYHTGABMYN
NRKVTCADRTTWCH		 Misc
Kulakovskiy et al.(2013)
SIX1_HUMAN.H11MO.0.A 		0.865 0.982
Six1
M09579_2.00 		Mus musculus
GWAAYHTGABMH
DKVTCADRTTWC		 Misc
Heinz et al.(2010)
Myoblast-Six1_GSE20150 		0.865 0.982
SIX1
M10684_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX1_Q3_01 		0.865 0.982
SIX1
M10685_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX1_Q3 		0.865 0.982
SIX1
M05095_2.00 		Homo sapiens
NNYGATABNB
VNVTATCRNN		 SELEX
Yin et al.(2017)
SIX1_eDBD_Methyl-HT-SELEX 		0.865 0.982
SIX1
M05097_2.00 		Homo sapiens
NNYGATAYSB
VSRTATCRNN		 SELEX
Yin et al.(2017)
SIX1_FL_Methyl-HT-SELEX 		0.865 0.982
Six4
M00461_2.00 		Mus musculus
NNKABMHNN
NNDKVTMNN		 PBM
Berger et al.(2008)
Six4_2860 		0.708 0.709
SIX4
M04939_2.00 		Homo sapiens
NVYGATACVB
VBGTATCRBN		 SELEX
Yin et al.(2017)
SIX4_eDBD_HT-SELEX 		0.708 0.709
Six4
M09198_2.00 		Mus musculus
DGDAABHNSASNNN
NNNSTSNDVTTHCH		 Misc
Kulakovskiy et al.(2013)
SIX4_MOUSE.H11MO.0.C 		0.708 0.709
SIX4
M10646_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX4_Q3 		0.708 0.709
SIX4
M04940_2.00 		Homo sapiens
NBGTAWCRHN
NDYGWTACVN		 SELEX
Yin et al.(2017)
SIX4_eDBD_Methyl-HT-SELEX 		0.708 0.709
Six4
M00563_2.00 		Drosophila melanogaster
NNDANMHNN
NNDKNTHNN		 PBM
Busser et al.(2012a)
Six4 		0.708 0.673
Six4
M06530_2.00 		Drosophila melanogaster
TGABAC
GTVTCA		 B1H
Mathelier et al.(2014)
MA0204.1 		0.708 0.673
Six4
M06334_2.00 		Drosophila melanogaster
WDDTGABAC
GTVTCAHHW		 B1H
Zhu et al.(2011)
Six4_Cell_FBgn0027364 		0.708 0.673
Six4
M06335_2.00 		Drosophila melanogaster
NTGAKACB
VGTMTCAN		 B1H
Zhu et al.(2011)
Six4_SOLEXA_2_FBgn0027364 		0.708 0.673
Six4
M06336_2.00 		Drosophila melanogaster
NNNTGABA
TVTCANNN		 B1H
Zhu et al.(2011)
Six4_SOLEXA_FBgn0027364 		0.708 0.673
SIX5
M08208_2.00 		Homo sapiens
GARWTGTAGT
ACTACAWYTC		 ChIP-seq
Contrino et al.(2012)
Mv121 		0.708 0.655
SIX5
M08209_2.00 		Homo sapiens
GGAGTTGT
ACAACTCC		 ChIP-seq
Contrino et al.(2012)
Mv123 		0.708 0.655
SIX5
M10738_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX5_01 		0.708 0.655
SIX5
M10739_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX5_02 		0.708 0.655
ceh-34
M00672_2.00 		Caenorhabditis elegans
NNNRDAWNNN
NNNWTHYNNN		 PBM
Narasimhan et al.(2015)
pTH9708 		0.664 0.618
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00425_2.00 Homeodomain 18 72

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000024947 Homeodomain 127 181
ENSMUSP00000125871 Homeodomain 127 181

Links

Other Homeodomain family TFs
Other Mus musculus TFs

541 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
EBF1 Homo sapiens ENSG00000164330 D 0.000
Myotis_brandtii_Ebf1_10034833 Myotis brandtii Myotis_brandtii_Ebf1_10034833 I 0.000
ebf2.S Xenopus laevis XB-GENE-971141 I 0.000
LDEC007542 Leptinotarsa decemlineata LDEC007542 I 0.000
LCUP013862 Lucilia cuprina LCUP013862 I 0.000
Sakowv30011033m.g Saccoglossus kowalevskii Sakowv30011033m.g I 0.000
Ocbimv22038949m.g Octopus bimaculoides Ocbimv22038949m.g I 0.000
estExt_gwp.C_3380002 Branchiostoma floridae estExt_gwp.C_3380002 I 0.000
Tal_R004164 Tyto alba Tal_R004164 I 0.000
Pvit_12666 Pogona vitticeps Pvit_12666 I 0.000
Pvit_12046 Pogona vitticeps Pvit_12046 I 0.000
Pvit_11383 Pogona vitticeps Pvit_11383 I 0.000
Myotis_brandtii_Ebf3_10024819 Myotis brandtii Myotis_brandtii_Ebf3_10024819 I 0.000
AALB010330 Anopheles albimanus AALB010330 I 0.000
Hsal_03263--XP_394171.3_APIME Harpegnathos saltator Hsal_03263--XP_394171.3_APIME I 0.000
Gfo_R013267 Geospiza fortis Gfo_R013267 I 0.000
ENSMMUP00000028570 Macaca fascicularis ENSMMUP00000028570 I 0.000
ENSBTAP00000053340-D1 Bos grunniens ENSBTAP00000053340-D1 I 0.000
Cflo_00077--XP_394171.3_APIME Camponotus floridanus Cflo_00077--XP_394171.3_APIME I 0.000
Brh_R003197 Buceros rhinoceros Brh_R003197 I 0.000
Brh_R001594 Buceros rhinoceros Brh_R001594 I 0.000
Alligator_sinensis_CCG017609.1 Alligator sinensis Alligator_sinensis_CCG017609.1 I 0.000
Alligator_sinensis_CCG000393.1 Alligator sinensis Alligator_sinensis_CCG000393.1 I 0.000
Afo_R012023 Aptenodytes forsteri Afo_R012023 I 0.000
Aan_R013029 Calypte anna Aan_R013029 I 0.000
AQUA007473 Anopheles quadriannulatus AQUA007473 I 0.000
scaffold24-EXSNAP2012.58 Pristionchus exspectatus scaffold24-EXSNAP2012.58 I 0.000
OESDEN_10293 Oesophagostomum dentatum OESDEN_10293 I 0.000
nRc.2.0.1.g14013 Romanomermis culicivorax nRc.2.0.1.g14013 I 0.000
nRc.2.0.1.g06532 Romanomermis culicivorax nRc.2.0.1.g06532 I 0.000
Hba_09581 Heterorhabditis bacteriophora Hba_09581 I 0.000
DILT_0000082701 Diphyllobothrium latum DILT_0000082701 I 0.000
BTMF_0000130101 Brugia timori BTMF_0000130101 I 0.000
MDOA011385 Musca domestica MDOA011385 I 0.000
BGLB009291 Biomphalaria glabrata BGLB009291 I 0.000
ASTEI06456 Anopheles stephensi ASTEI06456 I 0.000
ASIS004664 Anopheles sinensis ASIS004664 I 0.000
YQE_08127 Dendroctonus ponderosae YQE_08127 I 0.000
AMEM017983 Anopheles merus AMEM017983 I 0.000
AMEC016105 Anopheles melas AMEC016105 I 0.000
AFUN004906 Anopheles funestus AFUN004906 I 0.000
AFAF000230 Anopheles farauti AFAF000230 I 0.000
AEPI003553 Anopheles epiroticus AEPI003553 I 0.000
ACUA010350 Anopheles culicifacies ACUA010350 I 0.000
ACOM041529 Anopheles coluzzii ACOM041529 I 0.000
ACHR004409 Anopheles christyi ACHR004409 I 0.000
AATE014419 Anopheles atroparvus AATE014419 I 0.000
AARA002865 Anopheles arabiensis AARA002865 I 0.000
ENSCSAG00000010520 Chlorocebus sabaeus ENSCSAG00000010520 I 0.000
EBF3 Myotis lucifugus ENSMLUG00000005478 I 0.000
ENSMLUG00000004376 Myotis lucifugus ENSMLUG00000004376 I 0.000
ENSMGAG00000016563 Meleagris gallopavo ENSMGAG00000016563 I 0.000
ENSLACG00000017271 Latimeria chalumnae ENSLACG00000017271 I 0.000
ENSLACG00000005494 Latimeria chalumnae ENSLACG00000005494 I 0.000
ENSGMOG00000012325 Gadus morhua ENSGMOG00000012325 I 0.000
EBF1 Gorilla gorilla ENSGGOG00000000033 I 0.000
ENSFCAG00000027202 Felis catus ENSFCAG00000027202 I 0.000
EBF1 Equus caballus ENSECAG00000007964 I 0.000
EBF3 Dasypus novemcinctus ENSDNOG00000002588 I 0.000
ENSCSAVG00000000458 Ciona savignyi ENSCSAVG00000000458 I 0.000
EBF2 Myotis lucifugus ENSMLUG00000011509 I 0.000
EBF4 Callithrix jacchus ENSCJAG00000021027 I 0.000
EBF3 Bos taurus ENSBTAG00000008272 I 0.000
ENSAMXG00000001200 Astyanax mexicanus ENSAMXG00000001200 I 0.000
ENSAMEG00000006442 Ailuropoda melanoleuca ENSAMEG00000006442 I 0.000
ENSACAG00000010823 Anolis carolinensis ENSACAG00000010823 I 0.000
ENSACAG00000003097 Anolis carolinensis ENSACAG00000003097 I 0.000
CJA00446 Caenorhabditis japonica CJA00446 I 0.000
BGIBMGA011565 Bombyx mori BGIBMGA011565 I 0.000
ADAC003479 Anopheles darlingi ADAC003479 I 0.000
ACYPI007722 Acyrthosiphon pisum ACYPI007722 I 0.000
EBF1 Sus scrofa ENSSSCG00000017046 I 0.000
Ppa-unc-3 Pristionchus pacificus PPA20518 I 0.000
MCINX016126 Melitaea cinxia MCINX016126 I 0.000
LotgiG225788 Lottia gigantea LotgiG225788 I 0.000
HMEL014948 Heliconius melpomene HMEL014948 I 0.000
HelroG112029 Helobdella robusta HelroG112029 I 0.000
GH12956 Drosophila grimshawi FBgn0120434 I 0.000
ENSXMAG00000010351 Xiphophorus maculatus ENSXMAG00000010351 I 0.000
ENSXMAG00000006633 Xiphophorus maculatus ENSXMAG00000006633 I 0.000
EBF1 Tetraodon nigroviridis ENSTNIG00000016148 I 0.000
ENSSTOG00000011505 Ictidomys tridecemlineatus ENSSTOG00000011505 I 0.000
ENSSTOG00000007966 Ictidomys tridecemlineatus ENSSTOG00000007966 I 0.000
ACEP22947 Atta cephalotes ACEP22947 I 0.000
Ebf1 Rattus norvegicus ENSRNOG00000028845 I 0.000
ENSPSIG00000005604 Pelodiscus sinensis ENSPSIG00000005604 I 0.000
ENSPMAG00000003287 Petromyzon marinus ENSPMAG00000003287 I 0.000
ENSPFOG00000002559 Poecilia formosa ENSPFOG00000002559 I 0.000
ENSPANG00000010656 Papio anubis ENSPANG00000010656 I 0.000
ENSOARG00000012836 Ovis aries ENSOARG00000012836 I 0.000
ENSOANG00000004212 Ornithorhynchus anatinus ENSOANG00000004212 I 0.000
ENSMPUG00000013414 Mustela putorius furo ENSMPUG00000013414 I 0.000
EBF1 Macaca mulatta ENSMMUG00000021696 I 0.000
EBF4 Macaca mulatta ENSMMUG00000021331 I 0.000