Six6 (Mus musculus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSMUSG00000021099 T212416_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Six6
M00169_2.00		 Mus musculus
NNAYMNN
NNKRTNN		 PBM
Badis et al.(2009)
Six6_2267		 (Direct) (Direct)
Six6
M00412_2.00		 Mus musculus
NNNTGATAYCN
NGRTATCANNN		 PBM
Berger et al.(2008)
Six6_2267		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SIX6
M00326_2.00 		Homo sapiens
NNDATMB
VKATHNN		 PBM
Barrera et al.(2016)
SIX6_REF 		0.867 1.000
SIX6
M05357_2.00 		Homo sapiens
NNYGATASVB
VBSTATCRNN		 SELEX
Yin et al.(2017)
SIX6_eDBD_HT-SELEX 		0.867 1.000
SIX6
M05358_2.00 		Homo sapiens
VBVYAYCRNN
NNYGRTRBVB		 SELEX
Yin et al.(2017)
SIX6_eDBD_Methyl-HT-SELEX 		0.867 1.000
Six3
M00483_2.00 		Mus musculus
NNNAYMN
NKRTNNN		 PBM
Berger et al.(2008)
Six3_1732 		0.865 0.982
SIX3
M05159_2.00 		Homo sapiens
NNYGATABBN
NVVTATCRNN		 SELEX
Yin et al.(2017)
SIX3_eDBD_HT-SELEX 		0.865 0.982
SIX3
M10698_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIX3_Q6 		0.865 0.982
SIX6
M00325_2.00 		Homo sapiens
NNNDATMB
VKATHNNN		 PBM
Barrera et al.(2016)
SIX6_H141N 		0.865 0.982
SIX3
M05160_2.00 		Homo sapiens
NNYGATABVB
VBVTATCRNN		 SELEX
Yin et al.(2017)
SIX3_eDBD_Methyl-HT-SELEX 		0.865 0.982
six3
M02102_2.00 		Oryzias latipes
NNDAYMBNNN
NNNVKRTHNN		 PBM
Weirauch et al.(2014)
pTH5928 		0.865 0.947
Optix
M02124_2.00 		Drosophila melanogaster
NNNNNDATMN
NKATHNNNNN		 PBM
Weirauch et al.(2014)
pTH5437 		0.865 0.930
Optix
M03850_2.00 		Drosophila melanogaster
TAATYTAATTA
TAATTARATTA		 SELEX
Nitta et al.(2015)
Optix_1 		0.865 0.930
Optix
M06526_2.00 		Drosophila melanogaster
TGATA
TATCA		 B1H
Mathelier et al.(2014)
MA0199.1 		0.865 0.930
Optix
M06327_2.00 		Drosophila melanogaster
HHVTGATA
TATCABDD		 B1H
Zhu et al.(2011)
Optix_Cell_FBgn0025360 		0.865 0.930
Optix
M06328_2.00 		Drosophila melanogaster
NNNTGATA
TATCANNN		 B1H
Zhu et al.(2011)
Optix_SOLEXA_FBgn0025360 		0.865 0.930
SIX6
M00327_2.00 		Homo sapiens
NHDAYMBNN
NNVKRTHDN		 PBM
Barrera et al.(2016)
SIX6_T165A 		0.860 0.982
For this family, TFs with SR scores > 0.599 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00169_2.00 Homeodomain 16 72
M00412_2.00 Homeodomain 16 72

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000021519 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Mus musculus TFs

296 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
AALB000417 Anopheles albimanus AALB000417 N 0.000
AALB008493 Anopheles albimanus AALB008493 N 0.000
AARA000520 Anopheles arabiensis AARA000520 N 0.000
AARA011013 Anopheles arabiensis AARA011013 N 0.000
AATE002453 Anopheles atroparvus AATE002453 N 0.000
ACEP16054 Atta cephalotes ACEP16054 N 0.000
ACEP16128 Atta cephalotes ACEP16128 N 0.000
ACEP18777 Atta cephalotes ACEP18777 N 0.000
ACHR005918 Anopheles christyi ACHR005918 N 0.000
ACHR009374 Anopheles christyi ACHR009374 N 0.000
ACUA008906 Anopheles culicifacies ACUA008906 N 0.000
ACUA018702 Anopheles culicifacies ACUA018702 N 0.000
ACUA028082 Anopheles culicifacies ACUA028082 N 0.000
ADAC010198 Anopheles darlingi ADAC010198 N 0.000
ADIR000207 Anopheles dirus ADIR000207 N 0.000
ADIR010892 Anopheles dirus ADIR010892 N 0.000
AEPI001841 Anopheles epiroticus AEPI001841 N 0.000
AEPI001845 Anopheles epiroticus AEPI001845 N 0.000
AEPI004511 Anopheles epiroticus AEPI004511 N 0.000
AFAF007434 Anopheles farauti AFAF007434 N 0.000
Afo_R005342 Aptenodytes forsteri Afo_R005342 N 0.000
AFUN001004 Anopheles funestus AFUN001004 N 0.000
AFUN010567 Anopheles funestus AFUN010567 N 0.000
AGAP011712 Anopheles gambiae AGAP011712 N 0.000
Alligator_sinensis_CCG010046.1 Alligator sinensis Alligator_sinensis_CCG010046.1 N 0.000
AMEC005290 Anopheles melas AMEC005290 N 0.000
AMEM005938 Anopheles merus AMEM005938 N 0.000
AMEM014364 Anopheles merus AMEM014364 N 0.000
AMIN000991 Anopheles minimus AMIN000991 N 0.000
AMIN008749 Anopheles minimus AMIN008749 N 0.000
ANCCAN_04327 Ancylostoma caninum ANCCAN_04327 N 0.000
ANCCEY_00583 Ancylostoma ceylanicum ANCCEY_00583 N 0.000
ANCDUO_17822 Ancylostoma duodenale ANCDUO_17822 N 0.000
ANCDUO_24135 Ancylostoma duodenale ANCDUO_24135 N 0.000
ANCDUO_27140 Ancylostoma duodenale ANCDUO_27140 N 0.000
AQUA000257 Anopheles quadriannulatus AQUA000257 N 0.000
AQUA010449 Anopheles quadriannulatus AQUA010449 N 0.000
ASIS020776 Anopheles sinensis ASIS020776 N 0.000
ASTEI10438 Anopheles stephensi ASTEI10438 N 0.000
A_04261 Schistosoma haematobium A_04261 N 0.000
BGIBMGA003174 Bombyx mori BGIBMGA003174 N 0.000
BGIBMGA006719 Bombyx mori BGIBMGA006719 N 0.000
BGIBMGA012898 Bombyx mori BGIBMGA012898 N 0.000
Bm3498 Brugia malayi Bm3498 I 0.000
Brh_R011566 Buceros rhinoceros Brh_R011566 N 0.000
Cflo_02417--XP_001121225.1_APIME Camponotus floridanus Cflo_02417--XP_001121225.1_APIME N 0.000
Cflo_07689--XP_001122560.1_APIME Camponotus floridanus Cflo_07689--XP_001122560.1_APIME N 0.000
CGOC_0001264301 Cylicostephanus goldi CGOC_0001264301 N 0.000
CLEC007098 Cimex lectularius CLEC007098 N 0.000
CPIJ000721 Culex quinquefasciatus CPIJ000721 N 0.000
CpipJ_CPIJ000721 Culex pipiens CpipJ_CPIJ000721 N 0.000
D915_02167 Fasciola hepatica D915_02167 N 0.000
DICVIV_10715 Dictyocaulus viviparus DICVIV_10715 N 0.000
DME_0000818901 Dracunculus medinensis DME_0000818901 N 0.000
ECANG7_07880 Echinococcus canadensis ECANG7_07880 N 0.000
ECPE_0000395601 Echinostoma caproni ECPE_0000395601 N 0.000
ENSCJAG00000000826 Callithrix jacchus ENSCJAG00000000826 N 0.000
ENSCSAVG00000000786 Ciona savignyi ENSCSAVG00000000786 I 0.000
ENSDORG00000012736 Dipodomys ordii ENSDORG00000012736 I 0.000
ENSECAG00000018160 Equus caballus ENSECAG00000018160 N 0.000
ENSETEG00000007920 Echinops telfairi ENSETEG00000007920 N 0.000
ENSOANG00000020395 Ornithorhynchus anatinus ENSOANG00000020395 I 0.000
ENSOANG00000029773 Ornithorhynchus anatinus ENSOANG00000029773 I 0.000
ENSPCAG00000011680 Procavia capensis ENSPCAG00000011680 N 0.000
ENSXMAG00000002873 Xiphophorus maculatus ENSXMAG00000002873 N 0.000
ENSXMAG00000005990 Xiphophorus maculatus ENSXMAG00000005990 N 0.000
EVEC_0000447801 Enterobius vermicularis EVEC_0000447801 N 0.000
GD16691 Drosophila simulans FBgn0188280 N 0.000
GF19461 Drosophila ananassae FBgn0096470 N 0.000
GG18707 Drosophila erecta FBgn0110916 N 0.000
GPUH_0002190501 Gongylonema pulchrum GPUH_0002190501 N 0.000
HCOI01136500 Haemonchus contortus HCOI01136500 N 0.000
HelroG89689 Helobdella robusta HelroG89689 N 0.000
HHAL010563-PA Halyomorpha halys HHAL010563-PA N 0.000
HMEL004264 Heliconius melpomene HMEL004264 N 0.000
HPBE_0001971401 Heligmosomoides bakeri HPBE_0001971401 N 0.000
Hsal_04126--XP_001122560.1_APIME Harpegnathos saltator Hsal_04126--XP_001122560.1_APIME I 0.000
Hsal_09269--XP_394607.3_APIME Harpegnathos saltator Hsal_09269--XP_394607.3_APIME N 0.000
ISCW019287 Ixodes scapularis ISCW019287 N 0.000
KGM_15500 Danaus plexippus KGM_15500 N 0.000
L798_01365 Zootermopsis nevadensis L798_01365 N 0.000
L798_14238 Zootermopsis nevadensis L798_14238 N 0.000
L892_g20532 Steinernema scapterisci L892_g20532 N 0.000
LCUP008640 Lucilia cuprina LCUP008640 N 0.000
LDEC010813 Leptinotarsa decemlineata LDEC010813 N 0.000
MCINX008208 Melitaea cinxia MCINX008208 N 0.000
MCINX015508 Melitaea cinxia MCINX015508 N 0.000
NBR_0000542501 Nippostrongylus brasiliensis NBR_0000542501 N 0.000
NBR_0001177301 Nippostrongylus brasiliensis NBR_0001177301 N 0.000
NBR_0002182001 Nippostrongylus brasiliensis NBR_0002182001 N 0.000
NECAME_11635 Necator americanus NECAME_11635 N 0.000
NECAME_19347 Necator americanus NECAME_19347 N 0.000
nOo.2.0.1.g12879 Onchocerca ochengi nOo.2.0.1.g12879 N 0.000
Ocbimv22001571m.g Octopus bimaculoides Ocbimv22001571m.g N 0.000
Ocbimv22013221m.g Octopus bimaculoides Ocbimv22013221m.g N 0.000
OESDEN_02780 Oesophagostomum dentatum OESDEN_02780 N 0.000
OESDEN_07954 Oesophagostomum dentatum OESDEN_07954 N 0.000
OFLC_0001184101 Onchocerca flexuosa OFLC_0001184101 N 0.000
Ogr11253 Ophisaurus gracilis Ogr11253 N 0.000
PPA14512 Pristionchus pacificus PPA14512 N 0.000
PPAI002123 Phlebotomus papatasi PPAI002123 N 0.000
PPAI007567 Phlebotomus papatasi PPAI007567 N 0.000
PXEA_0000704401 Protopolystoma xenopodis PXEA_0000704401 N 0.000
PXEA_0001803801 Protopolystoma xenopodis PXEA_0001803801 N 0.000
SINV10951 Solenopsis invicta SINV10951 N 0.000
SINV16738 Solenopsis invicta SINV16738 N 0.000
SINV17750 Solenopsis invicta SINV17750 I 0.000
SINV20004 Solenopsis invicta SINV20004 N 0.000
Smp_156650 Schistosoma mansoni Smp_156650 N 0.000
SMTD_0001100101 Schistosoma mattheei SMTD_0001100101 N 0.000
SMUV_0000075501 Syphacia muris SMUV_0000075501 N 0.000
SNAPOd2T00025688001 Oikopleura dioica SNAPOd2T00025688001 N 0.000
SPER_0002063901 Spirometra erinaceieuropaei SPER_0002063901 N 0.000
SPER_0003769001 Spirometra erinaceieuropaei SPER_0003769001 N 0.000
SPER_0003779701 Spirometra erinaceieuropaei SPER_0003779701 N 0.000
SPU_020346 Strongylocentrotus purpuratus SPU_020346 N 0.000
SVE_1701500 Strongyloides venezuelensis SVE_1701500 N 0.000
Tal_R004166 Tyto alba Tal_R004166 N 0.000
Tal_R010698 Tyto alba Tal_R010698 N 0.000
TBX10 Canis familiaris ENSCAFG00000011264 I 0.000
TBX15 Bos taurus ENSBTAG00000007767 I 0.000
Tbx22 Mus musculus ENSMUSG00000031241 I 0.000
TBX5 Vicugna pacos ENSVPAG00000009445 I 0.000
TC015796 Tribolium castaneum TC015796 N 0.000
TELCIR_17829 Teladorsagia circumcincta TELCIR_17829 N 0.000
TRE_0001207201 Trichobilharzia regenti TRE_0001207201 N 0.000
TsM_001062700 Taenia solium TsM_001062700 N 0.000
YQE_06268 Dendroctonus ponderosae YQE_06268 N 0.000
YQE_10906 Dendroctonus ponderosae YQE_10906 N 0.000