SREBF1 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000072310 T034251_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SREBF1
M04062_2.00		 Homo sapiens
VHCACVCSAY
RTSGBGTGDB		 SELEX
Yin et al.(2017)
SREBF1_eDBD_HT-SELEX_1		 (Direct) (Direct)
SREBF1
M04063_2.00		 Homo sapiens
VHCRCGYGDB
VHCRCGYGDB		 SELEX
Yin et al.(2017)
SREBF1_eDBD_HT-SELEX_2		 (Direct) (Direct)
SREBF1
M04064_2.00		 Homo sapiens
MTCACVCCAY
RTGGBGTGAK		 SELEX
Yin et al.(2017)
SREBF1_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
SREBF1
M04065_2.00		 Homo sapiens
RTCACCTGAY
RTCAGGTGAY		 SELEX
Yin et al.(2017)
SREBF1_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
SREBF1
M08048_2.00		 Homo sapiens
VTCACSCCAY
RTGGSGTGAB		 ChIP-seq
Mathelier et al.(2014)
MA0595.1		 (Direct) (Direct)
SREBF1
M08711_2.00		 Homo sapiens
VTCACVYSAYH
DRTSRBGTGAB		 Misc
Kulakovskiy et al.(2013)
SRBP1_HUMAN.H11MO.0.A		 (Direct) (Direct)
SREBF1
M09796_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SREBF1_02		 (Direct) (Direct)
SREBF1
M09797_2.00		 Homo sapiens
NATCACGTGAB
VTCACGTGATN		 Transfac
Matys et al.(2006)
V$SREBP1_01		 (Direct) (Direct)
SREBF1
M09798_2.00		 Homo sapiens
KRTCACCCCAC
GTGGGGTGAYM		 Transfac
Matys et al.(2006)
V$SREBP1_02		 (Direct) (Direct)
SREBF1
M09799_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SREBP1_Q5		 (Direct) (Direct)
SREBF1
M09800_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SREBP1_Q6_01		 (Direct) (Direct)
SREBF1
M09801_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SREBP1_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Srebf1
M00754_2.00 		Mus musculus
VWCAYVYSAB
VTSRBRTGWB		 PBM
Weirauch et al.(2013)
pTH0914 		0.914 0.980
Srebf1
M01724_2.00 		Mus musculus
RWCAYVYBD
HVRBRTGWY		 PBM
Weirauch et al.(2014)
pTH5161 		0.914 0.980
Srebf1
M02816_2.00 		Mus musculus
RTCACGTGAY
RTCACGTGAY		 SELEX
Jolma et al.(2013)
Srebf1_1 		0.914 0.980
Srebf1
M08749_2.00 		Mus musculus
VTCASSYSABN
NVTSRSSTGAB		 Misc
Kulakovskiy et al.(2013)
SRBP1_MOUSE.H11MO.0.B 		0.914 0.980
HLH106
M03626_2.00 		Drosophila melanogaster
RTCACGTGAY
RTCACGTGAY		 SELEX
Nitta et al.(2015)
HLH106_1 		0.890 0.804
HLH106
M03627_2.00 		Drosophila melanogaster
NRTCACGCCAYH
DRTGGCGTGAYN		 SELEX
Nitta et al.(2015)
HLH106_2 		0.890 0.804
Srebf2
M01725_2.00 		Mus musculus
TSRCGTGA
TCACGYSA		 PBM
Weirauch et al.(2014)
pTH4327 		0.862 0.804
SREBF2
M02811_2.00 		Homo sapiens
RTCACGTGAY
RTCACGTGAY		 SELEX
Jolma et al.(2013)
SREBF2_1 		0.862 0.804
SREBF2
M03591_2.00 		Homo sapiens
NRTCACVCCAYH
DRTGGBGTGAYN		 SELEX
Nitta et al.(2015)
SREBF2_1 		0.862 0.804
SREBF2
M04219_2.00 		Homo sapiens
RTCACGCCAY
RTGGCGTGAY		 SELEX
Yin et al.(2017)
SREBF2_eDBD_HT-SELEX_1 		0.862 0.804
SREBF2
M04220_2.00 		Homo sapiens
ATCACGTGAY
RTCACGTGAT		 SELEX
Yin et al.(2017)
SREBF2_eDBD_HT-SELEX_2 		0.862 0.804
SREBF2
M08059_2.00 		Homo sapiens
RTCACVCCAB
VTGGBGTGAY		 ChIP-seq
Mathelier et al.(2014)
MA0596.1 		0.862 0.804
SREBF2
M08741_2.00 		Homo sapiens
NNYCWSBCCABBB
VVVTGGVSWGRNN		 Misc
Kulakovskiy et al.(2013)
SRBP2_HUMAN.H11MO.0.B 		0.862 0.804
Srebf2
M08752_2.00 		Mus musculus
NNYCWSBCCABBB
VVVTGGVSWGRNN		 Misc
Kulakovskiy et al.(2013)
SRBP2_MOUSE.H11MO.0.B 		0.862 0.804
SREBF2
M09462_2.00 		Homo sapiens
MNRTCACVCCAC
GTGGBGTGAYNK		 Misc
Heinz et al.(2010)
HepG2-Srebp2_GSE31477 		0.862 0.804
SREBF2
M09882_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SREBP2_Q6_01 		0.862 0.804
SREBF2
M09883_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SREBP2_Q6 		0.862 0.804
SREBF2
M04221_2.00 		Homo sapiens
RTCACVCCAY
RTGGBGTGAY		 SELEX
Yin et al.(2017)
SREBF2_eDBD_Methyl-HT-SELEX_1 		0.862 0.804
SREBF2
M04222_2.00 		Homo sapiens
RTCACSTGAY
RTCASGTGAY		 SELEX
Yin et al.(2017)
SREBF2_eDBD_Methyl-HT-SELEX_2 		0.862 0.804
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000261646 bHLH 324 374
ENSP00000348069 bHLH 354 404
ENSP00000379100 bHLH 70 120
ENSP00000379106 bHLH 70 120
ENSP00000411516 bHLH 298 325

Links

Other bHLH family TFs
Other Homo sapiens TFs

211 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ACYPI005432 Acyrthosiphon pisum ACYPI005432 I 0.864
AAEL010555 Aedes aegypti AAEL010555 I 0.867
ENSAMEG00000005129 Ailuropoda melanoleuca ENSAMEG00000005129 I 0.914
ENSAMEG00000015506 Ailuropoda melanoleuca ENSAMEG00000015506 I 0.862
Alligator_sinensis_CCG007971.1 Alligator sinensis Alligator_sinensis_CCG007971.1 I 0.862
Alligator_sinensis_CCG012315.1 Alligator sinensis Alligator_sinensis_CCG012315.1 I 0.890
ENSAPLG00000003145 Anas platyrhynchos ENSAPLG00000003145 I 0.860
ANCCAN_02634 Ancylostoma caninum ANCCAN_02634 I 0.848
ANCCEY_06558 Ancylostoma ceylanicum ANCCEY_06558 I 0.848
SREBF1 Anolis carolinensis ENSACAG00000001181 I 0.866
SREBF2 Anolis carolinensis ENSACAG00000004146 I 0.862
AALB006631 Anopheles albimanus AALB006631 I 0.867
AARA001097 Anopheles arabiensis AARA001097 I 0.867
AATE001073 Anopheles atroparvus AATE001073 I 0.867
ACHR009884 Anopheles christyi ACHR009884 I 0.867
ACOM033566 Anopheles coluzzii ACOM033566 I 0.867
ACUA020889 Anopheles culicifacies ACUA020889 I 0.867
ADAC008255 Anopheles darlingi ADAC008255 I 0.867
ADIR000987 Anopheles dirus ADIR000987 I 0.867
AEPI007594 Anopheles epiroticus AEPI007594 I 0.867
AFAF018960 Anopheles farauti AFAF018960 I 0.867
AFUN011560 Anopheles funestus AFUN011560 I 0.867
AGAP000076 Anopheles gambiae AGAP000076 I 0.867
AMAM021165 Anopheles maculatus AMAM021165 I 0.867
AMEC015010 Anopheles melas AMEC015010 I 0.867
AMEM008702 Anopheles merus AMEM008702 I 0.867
AMIN002144 Anopheles minimus AMIN002144 I 0.867
AQUA008327 Anopheles quadriannulatus AQUA008327 I 0.867
ASIS002143 Anopheles sinensis ASIS002143 I 0.867
ASTEI06218 Anopheles stephensi ASTEI06218 I 0.867
GB54953 Apis mellifera GB54953 I 0.888
Afo_R007963 Aptenodytes forsteri Afo_R007963 I 0.862
ENSAMXG00000008028 Astyanax mexicanus ENSAMXG00000008028 I 0.862
ENSAMXG00000009016 Astyanax mexicanus ENSAMXG00000009016 I 0.914
BGIBMGA001211 Bombyx mori BGIBMGA001211 I 0.861
ENSBTAP00000018956-D1 Bos grunniens ENSBTAP00000018956-D1 I 0.862
ENSP00000348069-D1 Bos grunniens ENSP00000348069-D1 I 0.855
SREBF1 Bos taurus ENSBTAG00000007884 I 0.914
SREBF2 Bos taurus ENSBTAG00000014265 I 0.862
ENSCJAG00000002378 Callithrix jacchus ENSCJAG00000002378 I 0.862
SREBF1 Callithrix jacchus ENSCJAG00000008953 I 0.914
Aan_R009070 Calypte anna Aan_R009070 I 0.914
Aan_R013218 Calypte anna Aan_R013218 I 0.862
SREBF2 Canis familiaris ENSCAFG00000001013 I 0.862
SREBF1 Canis familiaris ENSCAFG00000018436 I 0.914
CapteG165299 Capitella teleta CapteG165299 I 0.855
SREBF1 Cavia porcellus ENSCPOG00000002439 I 0.914
SREBF2 Cavia porcellus ENSCPOG00000013199 I 0.862
Cmyd_10007930 Chelonia mydas Cmyd_10007930 I 0.862
Cmyd_10008393 Chelonia mydas Cmyd_10008393 I 0.874
ENSCSAG00000005734 Chlorocebus sabaeus ENSCSAG00000005734 I 0.862
ENSCSAG00000008412 Chlorocebus sabaeus ENSCSAG00000008412 I 0.914
CGI_10004108 Crassostrea gigas CGI_10004108 I 0.866
CpipJ_CPIJ008607 Culex pipiens CpipJ_CPIJ008607 I 0.853
CpipJ_CPIJ018167 Culex pipiens CpipJ_CPIJ018167 I 0.867
CPIJ008607 Culex quinquefasciatus CPIJ008607 I 0.853
CPIJ018167 Culex quinquefasciatus CPIJ018167 I 0.867
KGM_21476 Danaus plexippus KGM_21476 I 0.885
srebf2 Danio rerio ENSDARG00000063438 I 0.862
srebf1 Danio rerio ENSDARG00000067607 I 0.914
DAPPUDRAFT_201893 Daphnia pulex DAPPUDRAFT_201893 I 0.851
SREBF2 Dasypus novemcinctus ENSDNOG00000048031 I 0.862
YQE_07365 Dendroctonus ponderosae YQE_07365 I 0.890
DICVIV_05621 Dictyocaulus viviparus DICVIV_05621 I 0.848
Srebf2 Dipodomys ordii ENSDORG00000000691 I 0.862
Srebf1 Dipodomys ordii ENSDORG00000012333 I 0.914
SREBP Drosophila ananassae FBgn0100584 I 0.890
SREBP Drosophila erecta FBgn0108291 I 0.890
SREBP Drosophila grimshawi FBgn0122129 I 0.890
HLH106 Drosophila melanogaster FBgn0261283 D 0.890
SREBP Drosophila mojavensis FBgn0134398 I 0.869
SREBP Drosophila persimilis FBgn0153336 I 0.890
SREBP Drosophila pseudoobscura FBgn0081122 I 0.890
SREBP Drosophila sechellia FBgn0174544 I 0.890
SREBP Drosophila simulans FBgn0186498 I 0.890
SREBP Drosophila virilis FBgn0198580 I 0.890
SREBP Drosophila willistoni FBgn0219495 I 0.890
SREBP Drosophila yakuba FBgn0236960 I 0.890
SREBF2 Echinops telfairi ENSETEG00000000459 I 0.862
SREBF1 Echinops telfairi ENSETEG00000004179 I 0.914
SREBF1 Equus caballus ENSECAG00000019802 I 0.914
SREBF2 Equus caballus ENSECAG00000024608 I 0.862
SREBF2 Erinaceus europaeus ENSEEUG00000003437 I 0.862
SREBF1 Felis catus ENSFCAG00000001983 I 0.914
SREBF2 Felis catus ENSFCAG00000014289 I 0.862
ENSFALG00000011811 Ficedula albicollis ENSFALG00000011811 I 0.862
ENSFALG00000013762 Ficedula albicollis ENSFALG00000013762 I 0.914
ENSGMOG00000006325 Gadus morhua ENSGMOG00000006325 I 0.862
ENSGMOG00000011626 Gadus morhua ENSGMOG00000011626 I 0.882
ENSGALG00000011916 Gallus gallus ENSGALG00000011916 I 0.860
SREBF1 Gallus gallus ENSGALG00000027188 I 0.914
srebf2 Gasterosteus aculeatus ENSGACG00000007259 I 0.862
srebf1 Gasterosteus aculeatus ENSGACG00000012064 I 0.914
Gfo_R004756 Geospiza fortis Gfo_R004756 I 0.862
Gfo_R006283 Geospiza fortis Gfo_R006283 I 0.914
SREBF1 Gorilla gorilla ENSGGOG00000002713 I 0.914
SREBF2 Gorilla gorilla ENSGGOG00000012065 I 0.862
HCOI01299300 Haemonchus contortus HCOI01299300 I 0.848
HCOI02041100 Haemonchus contortus HCOI02041100 I 0.848
HHAL003331-PA Halyomorpha halys HHAL003331-PA I 0.845
Hsal_02671--XP_396866.3_APIME Harpegnathos saltator Hsal_02671--XP_396866.3_APIME I 0.888
HMEL008680 Heliconius melpomene HMEL008680 I 0.885
HelroG138368 Helobdella robusta HelroG138368 I 0.846
HelroG66987 Helobdella robusta HelroG66987 I 0.848
SREBF2 Homo sapiens ENSG00000198911 D 0.862
ENSSTOG00000012916 Ictidomys tridecemlineatus ENSSTOG00000012916 I 0.862
ENSSTOG00000014939 Ictidomys tridecemlineatus ENSSTOG00000014939 I 0.914
ENSLACG00000013149 Latimeria chalumnae ENSLACG00000013149 I 0.914
ENSLOCG00000008766 Lepisosteus oculatus ENSLOCG00000008766 I 0.914
ENSLOCG00000011887 Lepisosteus oculatus ENSLOCG00000011887 I 0.862
LotgiG224211 Lottia gigantea LotgiG224211 I 0.890
SREBF2 Loxodonta africana ENSLAFG00000005791 I 0.862
SREBF1 Loxodonta africana ENSLAFG00000021644 I 0.914
LCUP004742 Lucilia cuprina LCUP004742 I 0.879
ENSP00000348069 Macaca fascicularis ENSP00000348069 I 0.914
ENSP00000354476 Macaca fascicularis ENSP00000354476 I 0.862
SREBF2 Macaca mulatta ENSMMUG00000003357 I 0.862
SREBF1 Macaca mulatta ENSMMUG00000023375 I 0.914
ENSMEUG00000001306 Macropus eugenii ENSMEUG00000001306 I 0.914
ENSMEUG00000011986 Macropus eugenii ENSMEUG00000011986 I 0.862
MESCA001239 Megaselia scalaris MESCA001239 I 0.866
SREBF2 Meleagris gallopavo ENSMGAG00000012074 I 0.860
SREBF2 Microcebus murinus ENSMICG00000000913 I 0.862
SREBF1 Microcebus murinus ENSMICG00000012535 I 0.914
SREBF1 Monodelphis domestica ENSMODG00000014074 I 0.914
SREBF2 Monodelphis domestica ENSMODG00000016612 I 0.862
MDOA000648 Musca domestica MDOA000648 I 0.879
ENSMPUG00000000024 Mustela putorius furo ENSMPUG00000000024 I 0.914
ENSMPUG00000016372 Mustela putorius furo ENSMPUG00000016372 I 0.862
Srebf1 Mus musculus ENSMUSG00000020538 D 0.914
Srebf2 Mus musculus ENSMUSG00000022463 D 0.862
Myotis_brandtii_SREBF1_10023215 Myotis brandtii Myotis_brandtii_SREBF1_10023215 I 0.914
Myotis_brandtii_SREBF2_10014539 Myotis brandtii Myotis_brandtii_SREBF2_10014539 I 0.862
SREBF2 Myotis lucifugus ENSMLUG00000002549 I 0.862
NV10553 Nasonia vitripennis NV10553 I 0.890
NECAME_14255 Necator americanus NECAME_14255 I 0.848
NBR_0002173001 Nippostrongylus brasiliensis NBR_0002173001 I 0.848
ENSNLEG00000013625 Nomascus leucogenys ENSNLEG00000013625 I 0.914
SREBF2 Ochotona princeps ENSOPRG00000008570 N 0.856
SREBF1 Ochotona princeps ENSOPRG00000015069 I 0.914
Ocbimv22024635m.g Octopus bimaculoides Ocbimv22024635m.g I 0.858
Ogr11708 Ophisaurus gracilis Ogr11708 I 0.890
Ogr14454 Ophisaurus gracilis Ogr14454 I 0.862
ENSONIG00000002304 Oreochromis niloticus ENSONIG00000002304 I 0.914
ENSONIG00000008375 Oreochromis niloticus ENSONIG00000008375 I 0.862
SREBF2 Ornithorhynchus anatinus ENSOANG00000002461 I 0.862
SREBF1 Ornithorhynchus anatinus ENSOANG00000012278 I 0.914
SREBF2 Oryctolagus cuniculus ENSOCUG00000003178 I 0.862
srebf1 Oryzias latipes ENSORLG00000009437 I 0.914
srebf2 Oryzias latipes ENSORLG00000014672 I 0.862
SREBF1 Otolemur garnettii ENSOGAG00000002910 I 0.914
SREBF2 Otolemur garnettii ENSOGAG00000014736 I 0.862
ENSOARG00000001504 Ovis aries ENSOARG00000001504 I 0.914
ENSOARG00000018717 Ovis aries ENSOARG00000018717 I 0.862
SREBF2 Pan troglodytes ENSPTRG00000014439 I 0.862
ENSPANG00000008691 Papio anubis ENSPANG00000008691 I 0.862
ENSPANG00000023675 Papio anubis ENSPANG00000023675 I 0.914
ENSPSIG00000005996 Pelodiscus sinensis ENSPSIG00000005996 I 0.887
ENSPSIG00000014746 Pelodiscus sinensis ENSPSIG00000014746 I 0.862
ENSPMAG00000001400 Petromyzon marinus ENSPMAG00000001400 I 0.885
ENSPMAG00000009384 Petromyzon marinus ENSPMAG00000009384 I 0.847
PPAI004928 Phlebotomus papatasi PPAI004928 I 0.849
ENSPFOG00000000475 Poecilia formosa ENSPFOG00000000475 I 0.862
ENSPFOG00000010306 Poecilia formosa ENSPFOG00000010306 I 0.914
Pvit_05020 Pogona vitticeps Pvit_05020 I 0.890
Pvit_18605 Pogona vitticeps Pvit_18605 I 0.862
ENSPPYG00000008037 Pongo abelii ENSPPYG00000008037 I 0.914
ENSPPYG00000011880 Pongo abelii ENSPPYG00000011880 I 0.862
SREBF2 Procavia capensis ENSPCAG00000006497 I 0.862
SREBF1 Procavia capensis ENSPCAG00000014903 I 0.914
SREBF2 Pteropus vampyrus ENSPVAG00000001177 I 0.862
SREBF1 Pteropus vampyrus ENSPVAG00000005765 I 0.914
Srebf1 Rattus norvegicus ENSRNOG00000003463 I 0.914
Srebf2 Rattus norvegicus ENSRNOG00000007400 I 0.862
RPRC014734 Rhodnius prolixus RPRC014734 I 0.845
Sakowv30028178m.g Saccoglossus kowalevskii Sakowv30028178m.g I 0.875
ENSSHAG00000011682 Sarcophilus harrisii ENSSHAG00000011682 I 0.862
ENSSHAG00000018607 Sarcophilus harrisii ENSSHAG00000018607 I 0.914
SINV16629 Solenopsis invicta SINV16629 I 0.888
ENSSARG00000002330 Sorex araneus ENSSARG00000002330 I 0.350
ENSSARG00000006597 Sorex araneus ENSSARG00000006597 I 0.862
L596_g18997 Steinernema carpocapsae L596_g18997 I 0.846
L889_g16826 Steinernema feltiae L889_g16826 I 0.846
L893_g8503 Steinernema glaseri L893_g8503 I 0.846
L898_g465 Steinernema monticolum L898_g465 I 0.846
L892_g28061 Steinernema scapterisci L892_g28061 I 0.846
SMAR011485 Strigamia maritima SMAR011485 I 0.888
ENSSSCG00000023124 Sus scrofa ENSSSCG00000023124 I 0.914
SREBF2 Sus scrofa ENSSSCG00000026092 I 0.862
SREBF1 Taeniopygia guttata ENSTGUG00000007313 I 0.914
ENSTGUG00000009772 Taeniopygia guttata ENSTGUG00000009772 I 0.862
srebf2 Takifugu rubripes ENSTRUG00000007413 I 0.862
srebf1 Takifugu rubripes ENSTRUG00000008197 I 0.882
TELCIR_06021 Teladorsagia circumcincta TELCIR_06021 I 0.848
TELCIR_07862 Teladorsagia circumcincta TELCIR_07862 I 0.848
tetur08g03870 Tetranychus urticae tetur08g03870 I 0.890
srebf2 Tetraodon nigroviridis ENSTNIG00000010835 I 0.862
srebf1 Tetraodon nigroviridis ENSTNIG00000011957 I 0.914
TC007163 Tribolium castaneum TC007163 I 0.864
SREBF2 Tupaia belangeri ENSTBEG00000016542 I 0.862
SREBF2 Tursiops truncatus ENSTTRG00000017350 I 0.862
Tal_R010023 Tyto alba Tal_R010023 I 0.862
SREBF2 Vicugna pacos ENSVPAG00000001280 N 0.856
srebf2.L Xenopus laevis XB-GENE-1011364 I 0.862
srebf2 Xenopus tropicalis XB-GENE-1011360 I 0.862
srebf1 Xenopus tropicalis XB-GENE-987572 I 0.914
XP_002944649 Xenopus tropicalis XP_002944649 I 0.914
ENSXMAG00000003080 Xiphophorus maculatus ENSXMAG00000003080 I 0.862
ENSXMAG00000014774 Xiphophorus maculatus ENSXMAG00000014774 I 0.914
L798_14382 Zootermopsis nevadensis L798_14382 I 0.888