HNF1A (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000135100 T209844_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HNF1A
M03150_2.00		 Homo sapiens
NGTTAATNATTAAYN
NRTTAATNATTAACN		 SELEX
Jolma et al.(2013)
HNF1A_1		 (Direct) (Direct)
HNF1A
M09144_2.00		 Homo sapiens
DGTTAATKATTAACH
DGTTAATMATTAACH		 Misc
Kulakovskiy et al.(2013)
HNF1A_HUMAN.H11MO.0.C		 (Direct) (Direct)
HNF1A
M10690_2.00		 Homo sapiens
RGTTAATDWTTRMHV
BDKYAAWHATTAACY		 Transfac
Matys et al.(2006)
V$HNF1_01		 (Direct) (Direct)
HNF1A
M10691_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF1A_Q4		 (Direct) (Direct)
HNF1A
M10692_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF1A_Q5		 (Direct) (Direct)
HNF1A
M10693_2.00		 Homo sapiens
DGBTAATBAWTHAMYWM
KWRKTDAWTVATTAVCH		 Transfac
Matys et al.(2006)
V$HNF1_C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hnf1b
M00408_2.00 		Mus musculus
NNHWCNNN
NNNGWDNN		 PBM
Berger et al.(2008)
Tcf2_0913 		0.866 0.945
HNF1B
M03245_2.00 		Homo sapiens
GTTAATNATTAAY
RTTAATNATTAAC		 SELEX
Jolma et al.(2013)
HNF1B_1 		0.866 0.945
HNF1B
M03246_2.00 		Homo sapiens
NGTTAATNATTAAYN
NRTTAATNATTAACN		 SELEX
Jolma et al.(2013)
HNF1B_2 		0.866 0.945
HNF1B
M09168_2.00 		Homo sapiens
DGTTAATRATTAACH
DGTTAATYATTAACH		 Misc
Kulakovskiy et al.(2013)
HNF1B_HUMAN.H11MO.0.A 		0.866 0.945
Hnf1b
M09179_2.00 		Mus musculus
DGTTAATRATTAACH
DGTTAATYATTAACH		 Misc
Kulakovskiy et al.(2013)
HNF1B_MOUSE.H11MO.0.A 		0.866 0.945
HNF1B
M10758_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF1B_Q6_01 		0.866 0.945
HNF1B
M10759_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF1B_Q6 		0.866 0.945
HNF1B
M10760_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$LFA1_Q6 		0.866 0.945
Hnf1a
M00171_2.00 		Mus musculus
HTAAYYNN
NNRRTTAD		 PBM
Badis et al.(2009)
Tcf1_2666 		0.860 0.982
Hnf1a
M00444_2.00 		Mus musculus
HTAAYYNNN
NNNRRTTAD		 PBM
Berger et al.(2008)
Tcf1_2666 		0.860 0.982
Hnf1a
M09191_2.00 		Mus musculus
RGTTAATNWTTDMHN
NDKHAAWNATTAACY		 Misc
Kulakovskiy et al.(2013)
HNF1A_MOUSE.H11MO.0.A 		0.860 0.982
Hmbox1
M00419_2.00 		Mus musculus
NNNGWNNN
NNNWCNNN		 PBM
Berger et al.(2008)
Hmbox1_2674 		0.638 0.382
HMBOX1
M03167_2.00 		Homo sapiens
BKTAACTARB
VYTAGTTAMV		 SELEX
Jolma et al.(2013)
HMBOX1_1 		0.638 0.382
HMBOX1
M05180_2.00 		Homo sapiens
BTAACYAGB
VCTRGTTAV		 SELEX
Yin et al.(2017)
HMBOX1_eDBD_HT-SELEX 		0.638 0.382
HMBOX1
M05181_2.00 		Homo sapiens
NTAACTAGB
VCTAGTTAN		 SELEX
Yin et al.(2017)
HMBOX1_eDBD_Methyl-HT-SELEX 		0.638 0.382
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000257555 Homeodomain 200 275
ENSP00000438804 Homeodomain 200 275
ENSP00000440361 Homeodomain 200 238
ENSP00000443112 Homeodomain 200 275
ENSP00000453965 Homeodomain 248 294
ENSP00000476181 Homeodomain 200 275

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

221 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSAMEG00000008387 Ailuropoda melanoleuca ENSAMEG00000008387 I 0.867
ENSAMEG00000013125 Ailuropoda melanoleuca ENSAMEG00000013125 I 0.866
ENSAMEG00000016028 Ailuropoda melanoleuca ENSAMEG00000016028 I 0.638
Alligator_sinensis_CCG002074.1 Alligator sinensis Alligator_sinensis_CCG002074.1 I 0.866
Alligator_sinensis_CCG014136.1 Alligator sinensis Alligator_sinensis_CCG014136.1 I 0.867
ENSAPLG00000002580 Anas platyrhynchos ENSAPLG00000002580 I 0.867
ENSAPLG00000006003 Anas platyrhynchos ENSAPLG00000006003 I 0.638
HNF1B Anolis carolinensis ENSACAG00000006458 I 0.866
HMBOX1 Anolis carolinensis ENSACAG00000010160 I 0.638
Afo_R009049 Aptenodytes forsteri Afo_R009049 I 0.867
Afo_R011837 Aptenodytes forsteri Afo_R011837 I 0.638
Afo_R013605 Aptenodytes forsteri Afo_R013605 I 0.866
ENSAMXG00000004039 Astyanax mexicanus ENSAMXG00000004039 I 0.867
ENSAMXG00000005661 Astyanax mexicanus ENSAMXG00000005661 I 0.867
ENSAMXG00000011241 Astyanax mexicanus ENSAMXG00000011241 I 0.683
ENSAMXG00000018539 Astyanax mexicanus ENSAMXG00000018539 I 0.638
ENSAMXG00000024376 Astyanax mexicanus ENSAMXG00000024376 I 0.865
ENSBTAP00000006184-D1 Bos grunniens ENSBTAP00000006184-D1 I 0.866
ENSBTAP00000029049-D1 Bos grunniens ENSBTAP00000029049-D1 I 0.867
ENSP00000401769-D1 Bos grunniens ENSP00000401769-D1 I 0.638
HNF1B Bos taurus ENSBTAG00000004710 I 0.866
HMBOX1 Bos taurus ENSBTAG00000010819 I 0.638
HNF1A Bos taurus ENSBTAG00000021795 I 0.867
fgenesh2_kg.scaffold_157000001 Branchiostoma floridae fgenesh2_kg.scaffold_157000001 I 0.859
fgenesh2_kg.scaffold_214000001 Branchiostoma floridae fgenesh2_kg.scaffold_214000001 I 0.859
Brh_R011090 Buceros rhinoceros Brh_R011090 I 0.867
Brh_R012838 Buceros rhinoceros Brh_R012838 I 0.638
HNF1B Callithrix jacchus ENSCJAG00000015174 I 0.866
HMBOX1 Callithrix jacchus ENSCJAG00000015654 I 0.638
Aan_R008292 Calypte anna Aan_R008292 I 0.867
Aan_R010756 Calypte anna Aan_R010756 I 0.638
Aan_R014136 Calypte anna Aan_R014136 I 0.866
HMBOX1 Canis familiaris ENSCAFG00000008237 I 0.638
HNF1A Canis familiaris ENSCAFG00000010502 I 0.867
HNF1B Canis familiaris ENSCAFG00000018150 I 0.866
CapteG124171 Capitella teleta CapteG124171 I 0.631
HNF1B Cavia porcellus ENSCPOG00000001234 I 0.866
HNF1A Cavia porcellus ENSCPOG00000007242 I 0.867
HMBOX1 Cavia porcellus ENSCPOG00000011124 I 0.638
Cmyd_10005161 Chelonia mydas Cmyd_10005161 I 0.867
Cmyd_10005786 Chelonia mydas Cmyd_10005786 I 0.638
Cmyd_10016186 Chelonia mydas Cmyd_10016186 I 0.866
ENSCSAG00000002227 Chlorocebus sabaeus ENSCSAG00000002227 I 0.867
ENSCSAG00000006125 Chlorocebus sabaeus ENSCSAG00000006125 I 0.866
ENSCSAG00000015894 Chlorocebus sabaeus ENSCSAG00000015894 I 0.638
HMBOX1 Choloepus hoffmanni ENSCHOG00000005538 I 0.638
HNF1B Choloepus hoffmanni ENSCHOG00000006010 I 0.866
ENSCING00000007645 Ciona intestinalis ENSCING00000007645 I 0.827
ENSCSAVG00000009827 Ciona savignyi ENSCSAVG00000009827 I 0.829
hnf1ba Danio rerio ENSDARG00000006615 I 0.867
hnf1a Danio rerio ENSDARG00000009470 I 0.822
hmbox1b Danio rerio ENSDARG00000018913 I 0.638
hnf1bb Danio rerio ENSDARG00000022295 I 0.865
hmbox1a Danio rerio ENSDARG00000027082 I 0.638
zgc:91944 Danio rerio ENSDARG00000035887 I 0.683
HNF1A Dasypus novemcinctus ENSDNOG00000000374 I 0.867
HNF1B Dasypus novemcinctus ENSDNOG00000001586 I 0.866
HMBOX1 Dasypus novemcinctus ENSDNOG00000031840 I 0.638
Hnf1a Dipodomys ordii ENSDORG00000007676 I 0.867
Hnf1b Dipodomys ordii ENSDORG00000009669 I 0.866
Hmbox1 Dipodomys ordii ENSDORG00000015971 N 0.676
HMBOX1 Equus caballus ENSECAG00000008240 I 0.638
HNF1B Equus caballus ENSECAG00000015854 I 0.866
HNF1A Equus caballus ENSECAG00000019954 I 0.867
HNF1B Erinaceus europaeus ENSEEUG00000004998 I 0.867
HNF1B Felis catus ENSFCAG00000000241 I 0.866
HNF1A Felis catus ENSFCAG00000009638 I 0.867
HMBOX1 Felis catus ENSFCAG00000022672 I 0.638
ENSFALG00000005101 Ficedula albicollis ENSFALG00000005101 I 0.867
ENSFALG00000007499 Ficedula albicollis ENSFALG00000007499 I 0.867
ENSFALG00000010859 Ficedula albicollis ENSFALG00000010859 I 0.638
ENSGMOG00000001038 Gadus morhua ENSGMOG00000001038 I 0.867
ENSGMOG00000002742 Gadus morhua ENSGMOG00000002742 I 0.638
ENSGMOG00000004622 Gadus morhua ENSGMOG00000004622 I 0.683
ENSGMOG00000006872 Gadus morhua ENSGMOG00000006872 I 0.638
ENSGMOG00000016065 Gadus morhua ENSGMOG00000016065 I 0.867
HNF1B Gallus gallus ENSGALG00000005504 I 0.866
HNF1A Gallus gallus ENSGALG00000006968 I 0.867
HMBOX1 Gallus gallus ENSGALG00000016633 I 0.638
hmbox1b Gasterosteus aculeatus ENSGACG00000004391 I 0.638
zgc:91944 Gasterosteus aculeatus ENSGACG00000009223 I 0.683
hnf1ba Gasterosteus aculeatus ENSGACG00000011101 I 0.867
hnf1a Gasterosteus aculeatus ENSGACG00000012691 I 0.809
Gfo_R008926 Geospiza fortis Gfo_R008926 I 0.638
Gfo_R010877 Geospiza fortis Gfo_R010877 I 0.867
Gfo_R012758 Geospiza fortis Gfo_R012758 I 0.867
HMBOX1 Gorilla gorilla ENSGGOG00000000860 I 0.638
HNF1A Gorilla gorilla ENSGGOG00000004329 I 0.867
HNF1B Gorilla gorilla ENSGGOG00000006322 I 0.866
HelroG166133 Helobdella robusta HelroG166133 I 0.631
HMBOX1 Homo sapiens ENSG00000147421 D 0.676
HNF1B Homo sapiens ENSG00000275410 D 0.866
ENSSTOG00000004719 Ictidomys tridecemlineatus ENSSTOG00000004719 I 0.867
ENSSTOG00000012440 Ictidomys tridecemlineatus ENSSTOG00000012440 I 0.866
ENSLACG00000003225 Latimeria chalumnae ENSLACG00000003225 N 0.676
ENSLACG00000011304 Latimeria chalumnae ENSLACG00000011304 I 0.638
ENSLACG00000012983 Latimeria chalumnae ENSLACG00000012983 I 0.867
ENSLACG00000017915 Latimeria chalumnae ENSLACG00000017915 I 0.867
ENSLOCG00000001916 Lepisosteus oculatus ENSLOCG00000001916 I 0.638
ENSLOCG00000002874 Lepisosteus oculatus ENSLOCG00000002874 I 0.867
ENSLOCG00000005942 Lepisosteus oculatus ENSLOCG00000005942 I 0.867
ENSLOCG00000015994 Lepisosteus oculatus ENSLOCG00000015994 I 0.638
HNF1B Loxodonta africana ENSLAFG00000002573 I 0.866
HNF1A Loxodonta africana ENSLAFG00000017872 I 0.867
HMBOX1 Loxodonta africana ENSLAFG00000032318 I 0.638
ENSP00000225893 Macaca fascicularis ENSP00000225893 I 0.866
ENSP00000257555 Macaca fascicularis ENSP00000257555 I 0.867
ENSP00000401769 Macaca fascicularis ENSP00000401769 I 0.638
HNF1B Macaca mulatta ENSMMUG00000003431 I 0.866
HMBOX1 Macaca mulatta ENSMMUG00000014981 I 0.638
ENSMEUG00000004163 Macropus eugenii ENSMEUG00000004163 I 0.867
ENSMEUG00000015023 Macropus eugenii ENSMEUG00000015023 I 0.638
HNF1B Meleagris gallopavo ENSMGAG00000008126 I 0.867
HNF1A Meleagris gallopavo ENSMGAG00000008538 I 0.867
HMBOX1 Microcebus murinus ENSMICG00000010422 N 0.676
HNF1A Monodelphis domestica ENSMODG00000002966 I 0.867
HMBOX1 Monodelphis domestica ENSMODG00000008788 I 0.638
HNF1B Monodelphis domestica ENSMODG00000019108 I 0.866
ENSMPUG00000001070 Mustela putorius furo ENSMPUG00000001070 I 0.638
ENSMPUG00000003290 Mustela putorius furo ENSMPUG00000003290 I 0.867
ENSMPUG00000015004 Mustela putorius furo ENSMPUG00000015004 I 0.866
Hnf1b Mus musculus ENSMUSG00000020679 D 0.866
Hmbox1 Mus musculus ENSMUSG00000021972 D 0.676
Hnf1a Mus musculus ENSMUSG00000029556 D 0.860
Myotis_brandtii_HMBOX1_10012332 Myotis brandtii Myotis_brandtii_HMBOX1_10012332 I 0.638
Myotis_brandtii_HNF1A_10028127 Myotis brandtii Myotis_brandtii_HNF1A_10028127 I 0.867
Myotis_brandtii_HNF1B_10031016 Myotis brandtii Myotis_brandtii_HNF1B_10031016 I 0.866
HMBOX1 Myotis lucifugus ENSMLUG00000007478 I 0.638
HNF1A Myotis lucifugus ENSMLUG00000009109 I 0.867
HNF1B Myotis lucifugus ENSMLUG00000012260 I 0.866
ENSNLEG00000002919 Nomascus leucogenys ENSNLEG00000002919 I 0.866
ENSNLEG00000016701 Nomascus leucogenys ENSNLEG00000016701 I 0.638
HNF1A Ochotona princeps ENSOPRG00000001671 I 0.867
HNF1B Ochotona princeps ENSOPRG00000003933 I 0.866
HMBOX1 Ochotona princeps ENSOPRG00000013613 N 0.676
SNAPOd2T00002150001 Oikopleura dioica SNAPOd2T00002150001 I 0.843
Ogr03456 Ophisaurus gracilis Ogr03456 I 0.867
Ogr07758 Ophisaurus gracilis Ogr07758 N 0.656
ENSONIG00000001328 Oreochromis niloticus ENSONIG00000001328 I 0.638
ENSONIG00000007704 Oreochromis niloticus ENSONIG00000007704 I 0.683
ENSONIG00000011178 Oreochromis niloticus ENSONIG00000011178 I 0.822
ENSONIG00000013161 Oreochromis niloticus ENSONIG00000013161 I 0.867
HNF1A Ornithorhynchus anatinus ENSOANG00000014646 I 0.867
HNF1B Oryctolagus cuniculus ENSOCUG00000003682 I 0.866
HMBOX1 Oryctolagus cuniculus ENSOCUG00000017211 I 0.638
hnf1ba Oryzias latipes ENSORLG00000004564 I 0.867
hmbox1b Oryzias latipes ENSORLG00000016242 I 0.638
ENSORLG00000018971 Oryzias latipes ENSORLG00000018971 I 0.806
zgc:91944 Oryzias latipes ENSORLG00000020883 I 0.683
HNF1B Otolemur garnettii ENSOGAG00000000869 I 0.866
HMBOX1 Otolemur garnettii ENSOGAG00000001381 I 0.638
HNF1A Otolemur garnettii ENSOGAG00000009071 I 0.867
ENSOARG00000003338 Ovis aries ENSOARG00000003338 I 0.866
ENSOARG00000013764 Ovis aries ENSOARG00000013764 I 0.867
ENSOARG00000015036 Ovis aries ENSOARG00000015036 I 0.638
HNF1A Pan troglodytes ENSPTRG00000005551 I 0.867
HNF1B Pan troglodytes ENSPTRG00000009059 I 0.866
HMBOX1 Pan troglodytes ENSPTRG00000020127 I 0.638
ENSPANG00000008728 Papio anubis ENSPANG00000008728 I 0.867
ENSPANG00000014537 Papio anubis ENSPANG00000014537 I 0.638
ENSPANG00000022102 Papio anubis ENSPANG00000022102 I 0.866
ENSPSIG00000009511 Pelodiscus sinensis ENSPSIG00000009511 I 0.866
ENSPSIG00000013055 Pelodiscus sinensis ENSPSIG00000013055 I 0.867
ENSPSIG00000016826 Pelodiscus sinensis ENSPSIG00000016826 I 0.638
ENSPFOG00000000843 Poecilia formosa ENSPFOG00000000843 I 0.638
ENSPFOG00000009496 Poecilia formosa ENSPFOG00000009496 I 0.867
ENSPFOG00000012263 Poecilia formosa ENSPFOG00000012263 I 0.683
ENSPFOG00000013053 Poecilia formosa ENSPFOG00000013053 I 0.822
Pvit_03697 Pogona vitticeps Pvit_03697 I 0.867
Pvit_13545 Pogona vitticeps Pvit_13545 I 0.866
ENSPPYG00000008222 Pongo abelii ENSPPYG00000008222 I 0.866
ENSPPYG00000018480 Pongo abelii ENSPPYG00000018480 I 0.638
HNF1B Procavia capensis ENSPCAG00000008147 I 0.866
HMBOX1 Procavia capensis ENSPCAG00000012005 I 0.638
HNF1A Pteropus vampyrus ENSPVAG00000008044 I 0.867
HNF1B Pteropus vampyrus ENSPVAG00000010466 I 0.866
Hnf1a Rattus norvegicus ENSRNOG00000001183 I 0.867
Hnf1b Rattus norvegicus ENSRNOG00000002598 I 0.866
Hmbox1 Rattus norvegicus ENSRNOG00000013326 I 0.638
Sakowv30011728m.g Saccoglossus kowalevskii Sakowv30011728m.g I 0.855
ENSSHAG00000005052 Sarcophilus harrisii ENSSHAG00000005052 I 0.866
ENSSHAG00000016211 Sarcophilus harrisii ENSSHAG00000016211 I 0.638
HNF1B Sorex araneus ENSSARG00000007152 I 0.866
HMBOX1 Sorex araneus ENSSARG00000009365 N 0.676
SPU_002791 Strongylocentrotus purpuratus SPU_002791 I 0.675
SPU_008196 Strongylocentrotus purpuratus SPU_008196 N 0.823
SPU_010305 Strongylocentrotus purpuratus SPU_010305 I 0.843
SPU_022737 Strongylocentrotus purpuratus SPU_022737 I 0.675
HMBOX1 Sus scrofa ENSSSCG00000009682 I 0.638
HNF1A Sus scrofa ENSSSCG00000009919 I 0.867
HNF1B Sus scrofa ENSSSCG00000022417 I 0.866
HNF1A Taeniopygia guttata ENSTGUG00000009673 I 0.867
HMBOX1 Taeniopygia guttata ENSTGUG00000013324 I 0.638
hnf1ba Takifugu rubripes ENSTRUG00000003809 I 0.867
hmbox1b Takifugu rubripes ENSTRUG00000004378 I 0.638
zgc:91944 Takifugu rubripes ENSTRUG00000012550 I 0.683
hnf1a Takifugu rubripes ENSTRUG00000016222 I 0.822
ENSTSYG00000001109 Tarsius syrichta ENSTSYG00000001109 I 0.638
ENSTSYG00000010701 Tarsius syrichta ENSTSYG00000010701 I 0.866
hnf1a Tetraodon nigroviridis ENSTNIG00000011468 I 0.822
zgc:91944 Tetraodon nigroviridis ENSTNIG00000014025 I 0.683
hnf1ba Tetraodon nigroviridis ENSTNIG00000016225 I 0.867
EFV59137 Trichinella spiralis EFV59137 N 0.690
TriadG28952 Trichoplax adhaerens TriadG28952 I 0.770
D918_03762 Trichuris suis D918_03762 N 0.709
TTRE_0000607501 Trichuris trichiura TTRE_0000607501 N 0.709
HMBOX1 Tursiops truncatus ENSTTRG00000015467 I 0.638
HNF1B Tursiops truncatus ENSTTRG00000015910 I 0.866
Tal_R010417 Tyto alba Tal_R010417 I 0.867
hnf1b.S Xenopus laevis XB-GENE-17330995 I 0.865
hnf1b.L Xenopus laevis XB-GENE-485656 I 0.865
hmbox1.S Xenopus laevis XB-GENE-6078482 I 0.638
hnf1a.S Xenopus laevis XB-GENE-865049 I 0.867
hnf1a Xenopus tropicalis XB-GENE-484117 I 0.867
hnf1b Xenopus tropicalis XB-GENE-485652 I 0.865
XP_002939680 Xenopus tropicalis XP_002939680 I 0.865
ENSXMAG00000001795 Xiphophorus maculatus ENSXMAG00000001795 I 0.638
ENSXMAG00000003472 Xiphophorus maculatus ENSXMAG00000003472 I 0.822
ENSXMAG00000005730 Xiphophorus maculatus ENSXMAG00000005730 I 0.683
ENSXMAG00000011775 Xiphophorus maculatus ENSXMAG00000011775 I 0.867