ac (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0000022 T038386_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; chaeta morphogenesis; and positive regulation of antibacterial peptide biosynthetic process. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including ectoderm; extended germ band embryo; neuroblasts; presumptive embryonic/larval system; and thoracic segment. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ac
M03592_2.00
Drosophila melanogaster
AAAARCAGCTGYTTTT

AAAARCAGCTGYTTTT
SELEX
Nitta et al.(2015)
ac_1
(Direct) (Direct)
ac
M05902_2.00
Drosophila melanogaster
RCACCTGC

GCAGGTGY
B1H
Zhu et al.(2011)
ac_da_SANGER_5_FBgn0000022
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0070071 bHLH 27 91

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

3 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
GM19060 Drosophila sechellia FBgn0173962 I 0.914
ac Drosophila erecta FBgn0028822 I 0.914
ac Drosophila yakuba FBgn0022828 I 0.914