WT1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000184937 T095226_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
WT1
M00243_2.00		 Homo sapiens
NNNNNNN
NNNNNNN		 PBM
Barrera et al.(2016)
WT1_F392L		 (Direct) (Direct)
WT1
M00244_2.00		 Homo sapiens
NNNWAMWATATN
NATATWKTWNNN		 PBM
Barrera et al.(2016)
WT1_H373Y		 (Direct) (Direct)
WT1
M00245_2.00		 Homo sapiens
NNNNNNN
NNNNNNN		 PBM
Barrera et al.(2016)
WT1_R366C		 (Direct) (Direct)
WT1
M00246_2.00		 Homo sapiens
NNNNNNN
NNNNNNN		 PBM
Barrera et al.(2016)
WT1_R366L		 (Direct) (Direct)
WT1
M00247_2.00		 Homo sapiens
NWATATDAHNN
NNDTHATATWN		 PBM
Barrera et al.(2016)
WT1_R394L		 (Direct) (Direct)
WT1
M00248_2.00		 Homo sapiens
NNTATTWTATNNN
NNNATAWAATANN		 PBM
Barrera et al.(2016)
WT1_R394W		 (Direct) (Direct)
WT1
M00249_2.00		 Homo sapiens
NCYCCCCCVNN
NNBGGGGGRGN		 PBM
Barrera et al.(2016)
WT1_REF		 (Direct) (Direct)
WT1
M08937_2.00		 Homo sapiens
YYYCBBYYCCTCCYYCNCBY
RVGNGRRGGAGGRRVVGRRR		 Misc
Kulakovskiy et al.(2013)
WT1_HUMAN.H11MO.0.C		 (Direct) (Direct)
WT1
M10290_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q4		 (Direct) (Direct)
WT1
M10291_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q6_01		 (Direct) (Direct)
WT1
M10292_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q6_02		 (Direct) (Direct)
WT1
M10293_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Wt1
M08968_2.00 		Mus musculus
YYYCBBYYCCTCCYYCNCBY
RVGNGRRGGAGGRRVVGRRR		 Misc
Kulakovskiy et al.(2013)
WT1_MOUSE.H11MO.0.B 		0.827 1.000
Wt1
M10337_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_02 		0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00243_2.00 C2H2 ZF 15 39
M00243_2.00 C2H2 ZF 45 69
M00243_2.00 C2H2 ZF 75 97
M00243_2.00 C2H2 ZF 103 127
M00244_2.00 C2H2 ZF 15 39
M00244_2.00 C2H2 ZF 45 69
M00244_2.00 C2H2 ZF 75 97
M00244_2.00 C2H2 ZF 103 127
M00245_2.00 C2H2 ZF 15 39
M00245_2.00 C2H2 ZF 45 69
M00245_2.00 C2H2 ZF 75 97
M00245_2.00 C2H2 ZF 103 127
M00246_2.00 C2H2 ZF 15 39
M00246_2.00 C2H2 ZF 45 69
M00246_2.00 C2H2 ZF 75 97
M00246_2.00 C2H2 ZF 103 127
M00247_2.00 C2H2 ZF 15 39
M00247_2.00 C2H2 ZF 45 69
M00247_2.00 C2H2 ZF 75 97
M00247_2.00 C2H2 ZF 103 127
M00248_2.00 C2H2 ZF 15 39
M00248_2.00 C2H2 ZF 45 69
M00248_2.00 C2H2 ZF 75 97
M00248_2.00 C2H2 ZF 103 127
M00249_2.00 C2H2 ZF 15 39
M00249_2.00 C2H2 ZF 45 69
M00249_2.00 C2H2 ZF 75 97
M00249_2.00 C2H2 ZF 103 127

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000331327 C2H2 ZF 391 415
ENSP00000331327 C2H2 ZF 421 445
ENSP00000331327 C2H2 ZF 451 473
ENSP00000331327 C2H2 ZF 482 506
ENSP00000368370 C2H2 ZF 179 203
ENSP00000368370 C2H2 ZF 209 233
ENSP00000368370 C2H2 ZF 239 261
ENSP00000368370 C2H2 ZF 267 291
ENSP00000413452 C2H2 ZF 391 415
ENSP00000413452 C2H2 ZF 421 445
ENSP00000413452 C2H2 ZF 451 473
ENSP00000413452 C2H2 ZF 479 503
ENSP00000415516 C2H2 ZF 374 398
ENSP00000415516 C2H2 ZF 404 428
ENSP00000415516 C2H2 ZF 434 456
ENSP00000415516 C2H2 ZF 462 486
ENSP00000435307 C2H2 ZF 162 186
ENSP00000435307 C2H2 ZF 192 216
ENSP00000435307 C2H2 ZF 222 244
ENSP00000435624 C2H2 ZF 82 106
ENSP00000435624 C2H2 ZF 112 134
ENSP00000435624 C2H2 ZF 143 167
ENSP00000436292 C2H2 ZF 1 24

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

77 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSAMEG00000006957 Ailuropoda melanoleuca ENSAMEG00000006957 I 0.827
ENSAPLG00000005775 Anas platyrhynchos ENSAPLG00000005775 I 0.827
WT1 Bos taurus ENSBTAG00000047268 I 0.827
WT1 Canis familiaris ENSCAFG00000007426 I 0.827
WT1 Choloepus hoffmanni ENSCHOG00000006244 I 0.827
WT1 Callithrix jacchus ENSCJAG00000005900 I 0.827
ENSCSAG00000005257 Chlorocebus sabaeus ENSCSAG00000005257 I 0.827
WT1 Dasypus novemcinctus ENSDNOG00000003652 I 0.827
Wt1 Dipodomys ordii ENSDORG00000013725 I 0.827
ENSECAG00000022308 Equus caballus ENSECAG00000022308 I 0.827
ENSEEUG00000007221 Erinaceus europaeus ENSEEUG00000007221 I 0.827
WT1 Echinops telfairi ENSETEG00000000684 I 0.827
ENSFALG00000010820 Ficedula albicollis ENSFALG00000010820 I 0.827
WT1 Felis catus ENSFCAG00000000308 I 0.827
WT1 Gallus gallus ENSGALG00000012115 I 0.827
WT1 Gorilla gorilla ENSGGOG00000011586 I 0.827
WT1 Loxodonta africana ENSLAFG00000006160 I 0.827
ENSMGAG00000001489 Meleagris gallopavo ENSMGAG00000001489 I 0.827
WT1 Microcebus murinus ENSMICG00000004097 I 0.827
WT1 Myotis lucifugus ENSMLUG00000027523 I 0.827
WT1 Macaca mulatta ENSMMUG00000009881 I 0.827
WT1 Monodelphis domestica ENSMODG00000009646 I 0.827
ENSMPUG00000011307 Mustela putorius furo ENSMPUG00000011307 I 0.827
Wt1 Mus musculus ENSMUSG00000016458 D 0.827
ENSNLEG00000017890 Nomascus leucogenys ENSNLEG00000017890 I 0.827
ENSOANG00000015147 Ornithorhynchus anatinus ENSOANG00000015147 I 0.827
ENSOARG00000016334 Ovis aries ENSOARG00000016334 I 0.827
WT1 Oryctolagus cuniculus ENSOCUG00000005882 I 0.827
WT1 Otolemur garnettii ENSOGAG00000007118 I 0.827
ENSOPRG00000015709 Ochotona princeps ENSOPRG00000015709 I 0.827
ENSPANG00000019482 Papio anubis ENSPANG00000019482 I 0.827
ENSPPYG00000029822 Pongo abelii ENSPPYG00000029822 I 0.827
ENSPSIG00000013679 Pelodiscus sinensis ENSPSIG00000013679 I 0.827
WT1 Pan troglodytes ENSPTRG00000003476 I 0.827
ENSPVAG00000006895 Pteropus vampyrus ENSPVAG00000006895 N 0.827
Wt1 Rattus norvegicus ENSRNOG00000013074 I 0.827
ENSSARG00000000207 Sorex araneus ENSSARG00000000207 I 0.827
ENSSHAG00000017390 Sarcophilus harrisii ENSSHAG00000017390 I 0.827
WT1 Sus scrofa ENSSSCG00000013316 I 0.827
ENSSTOG00000023716 Ictidomys tridecemlineatus ENSSTOG00000023716 I 0.827
WT1 Taeniopygia guttata ENSTGUG00000004906 I 0.827
ENSTTRG00000012819 Tursiops truncatus ENSTTRG00000012819 N 0.827
ENSVPAG00000007788 Vicugna pacos ENSVPAG00000007788 I 0.827
Aan_R006616 Calypte anna Aan_R006616 I 0.827
Afo_R014628 Aptenodytes forsteri Afo_R014628 I 0.827
Alligator_sinensis_CCG012951.1 Alligator sinensis Alligator_sinensis_CCG012951.1 I 0.827
Cmyd_10016389 Chelonia mydas Cmyd_10016389 N 0.827
ENSP00000331327-D1 Bos grunniens ENSP00000331327-D1 I 0.827
ENSP00000331327 Macaca fascicularis ENSP00000331327 I 0.827
Gfo_R001970 Geospiza fortis Gfo_R001970 I 0.827
B5DE03 Xenopus tropicalis B5DE03 I 0.827
B7ZSG3 Xenopus laevis B7ZSG3 I 0.827
wt1 Xenopus tropicalis XB-GENE-484999 I 0.827
wt1.L Xenopus laevis XB-GENE-6252376 I 0.827
wt1.S Xenopus laevis XB-GENE-864792 I 0.827
ENSACAG00000002480 Anolis carolinensis ENSACAG00000002480 I 0.825
Pvit_09510 Pogona vitticeps Pvit_09510 I 0.825
ENSLACG00000016378 Latimeria chalumnae ENSLACG00000016378 I 0.824
WT1 Procavia capensis ENSPCAG00000002213 I 0.812
ENSAMXG00000013017 Astyanax mexicanus ENSAMXG00000013017 I 0.810
wt1a Danio rerio ENSDARG00000031420 I 0.810
ENSLOCG00000004537 Lepisosteus oculatus ENSLOCG00000004537 I 0.810
ENSONIG00000011043 Oreochromis niloticus ENSONIG00000011043 I 0.807
ENSPMAG00000008950 Petromyzon marinus ENSPMAG00000008950 I 0.807
ENSGMOG00000012296 Gadus morhua ENSGMOG00000012296 I 0.795
ENSONIG00000005545 Oreochromis niloticus ENSONIG00000005545 I 0.793
wt1 Oryzias latipes ENSORLG00000012424 I 0.793
wt1b Danio rerio ENSDARG00000007990 I 0.790
wt1b Gasterosteus aculeatus ENSGACG00000016020 I 0.790
wt1 Oryzias latipes ENSORLG00000009859 I 0.787
ENSPFOG00000010572 Poecilia formosa ENSPFOG00000010572 I 0.783
ENSXMAG00000005139 Xiphophorus maculatus ENSXMAG00000005139 I 0.783
wt1b Takifugu rubripes ENSTRUG00000006559 I 0.763
wt1b Tetraodon nigroviridis ENSTNIG00000013806 I 0.760
fgenesh2_pg.scaffold_80000039 Branchiostoma floridae fgenesh2_pg.scaffold_80000039 I 0.758
fgenesh2_pm.scaffold_110000013 Branchiostoma floridae fgenesh2_pm.scaffold_110000013 I 0.758