CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Mlx
(
Rattus norvegicus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSRNOG00000019983
T037221_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MLX (MAX dimerization protein MLX). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Mlx
M00752_2.00
Mus musculus
CACGTGNNN
NNNCACGTG
PBM
Weirauch et al.(2013)
pTH2882
0.914
1.000
Mlx
M01721_2.00
Mus musculus
NCRCGTGNNN
NNNCACGYGN
PBM
Weirauch et al.(2014)
pTH5070
0.914
1.000
MLX
M02779_2.00
Homo sapiens
RTCACGTGAY
RTCACGTGAY
SELEX
Jolma et al.(2013)
MLX_1
0.914
1.000
Mlx
M02815_2.00
Mus musculus
RTCACGTGAY
RTCACGTGAY
SELEX
Jolma et al.(2013)
Mlx_1
0.914
1.000
MLX
M04080_2.00
Homo sapiens
NCACGTGN
NCACGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_HT-SELEX
0.914
1.000
MLX
M04082_2.00
Homo sapiens
NVCACGTGVYN
NRBCACGTGBN
SELEX
Yin et al.(2017)
MLX_FL_HT-SELEX
0.914
1.000
MLX
M04081_2.00
Homo sapiens
NCACRTGV
BCAYGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_Methyl-HT-SELEX
0.914
1.000
MLX
M04083_2.00
Homo sapiens
NDBCACRTGBV
BVCAYGTGVHN
SELEX
Yin et al.(2017)
MLX_FL_Methyl-HT-SELEX
0.914
1.000
MLX
M01114_2.00
Monodelphis domestica
NNNCACGTGN
NCACGTGNNN
PBM
Lambert et al.(2019)
pTH11463
0.914
0.982
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000027116
bHLH
130
188
RRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLH
Links
Other
bHLH
family TFs
Other
Rattus norvegicus
TFs
51 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy