sage (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0037672 T038445_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and salivary gland development. Located in polytene chromosome. Is expressed in adult salivary gland; embryonic primordium of adult salivary gland; embryonic/larval salivary gland; embryonic/larval salivary gland body; and salivary gland body primordium. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to several human genes including MESP1 (mesoderm posterior bHLH transcription factor 1) and MESP2 (mesoderm posterior bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
sage
M03621_2.00		 Drosophila melanogaster
AAAACAGCTGTTTT
AAAACAGCTGTTTT		 SELEX
Nitta et al.(2015)
sage_1		 (Direct) (Direct)
sage
M05992_2.00		 Drosophila melanogaster
DAAMCABCTGY
RCAGVTGKTTH		 B1H
Zhu et al.(2011)
sage_da_SANGER_5_FBgn0037672		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0081462 bHLH 180 233
FBpp0312049 bHLH 180 233

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

17 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action