CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Glis3
(
Mus musculus
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSMUSG00000052942
T101288_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
GLIS3
M02880_2.00
Homo sapiens
CTTYGTGGGGGGTM
KACCCCCCACRAAG
SELEX
Jolma et al.(2013)
GLIS3_1
0.827
0.991
GLIS3
M10169_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_01
0.827
0.991
GLIS3
M10170_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_Q6_01
0.827
0.991
GLIS3
M10171_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_Q6
0.827
0.991
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000108231
C2H2 ZF
500
525
HCCRWIDCSALYDQQEELVRHIEKVH
ENSMUSP00000108231
C2H2 ZF
534
561
FTCFWTGCPRRYKPFNARYKLLIHMRVH
ENSMUSP00000108231
C2H2 ZF
568
591
KCTFEGCKKAFSRLENLKIHLRSH
ENSMUSP00000108231
C2H2 ZF
597
621
YLCQHPGCQKAFSNSSDRAKHQRTH
ENSMUSP00000108231
C2H2 ZF
627
651
YACQIPGCTKRYTDPSSLRKHVKAH
ENSMUSP00000124635
C2H2 ZF
500
525
HCCRWIDCSALYDQQEELVRHIEKVH
ENSMUSP00000124635
C2H2 ZF
534
561
FTCFWTGCPRRYKPFNARYKLLIHMRVH
ENSMUSP00000124635
C2H2 ZF
568
591
KCTFEGCKKAFSRLENLKIHLRSH
ENSMUSP00000124635
C2H2 ZF
597
621
YLCQHPGCQKAFSNSSDRAKHQRTH
ENSMUSP00000124635
C2H2 ZF
627
651
YACQIPGCTKRYTDPSSLRKHVKAH
Links
Other
C2H2 ZF
family TFs
Other
Mus musculus
TFs
81 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy