Dp (Drosophila melanogaster)
E2F

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02319 (E2F_TDP) IPR003316 FBgn0011763 T173067_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including dorsal/ventral axis specification, ovarian follicular epithelium; intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of nurse cell apoptotic process. Located in nucleus. Part of Myb complex and Rb-E2F complex. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; gut section; imaginal disc; and testis. Orthologous to several human genes including TFDP1 (transcription factor Dp-1) and TFDP2 (transcription factor Dp-2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TFDP1
M08108_2.00 		Homo sapiens
NSGCGGGAAVN
NBTTCCCGCSN		 ChIP-seq
Mathelier et al.(2014)
MA1122.1 		0.809 0.809
TFDP1
M09035_2.00 		Homo sapiens
VRDDGGCGGGAMDN
NHKTCCCGCCHHYB		 Misc
Kulakovskiy et al.(2013)
TFDP1_HUMAN.H11MO.0.C 		0.809 0.809
dpl-1
M09525_2.00 		Caenorhabditis elegans
GCGCGYHW
WDRCGCGC		 Misc
Heinz et al.(2010)
cElegans-Adult_modEncode 		0.735 0.735
For this family, TFs with SR scores > 0.429 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0086853 E2F 166 243
FBpp0086854 E2F 162 239
FBpp0305354 E2F 138 215

Links

Other E2F family TFs
Other Drosophila melanogaster TFs

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539 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action