FOXP2 (Homo sapiens)
Forkhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00250 (Forkhead) IPR001766 ENSG00000128573 T185769_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
FOXP2
M05866_2.00		 Homo sapiens
RTAAAYAWNN
NNWTRTTTAY		 SMiLE-seq
Isakova et al.(2017)
FOXP2		 (Direct) (Direct)
FOXP2
M08116_2.00		 Homo sapiens
NDGTAAACAVN
NBTGTTTACHN		 ChIP-seq
Mathelier et al.(2014)
MA0593.1		 (Direct) (Direct)
FOXP2
M09089_2.00		 Homo sapiens
DGTAAACAV
BTGTTTACH		 Misc
Kulakovskiy et al.(2013)
FOXP2_HUMAN.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Foxp2
M00792_2.00 		Mus musculus
RTAAACAD
HTGTTTAY		 PBM
Weirauch et al.(2013)
pTH1288 		0.713 0.972
Foxp2
M09101_2.00 		Mus musculus
NGTAAACAN
NTGTTTACN		 Misc
Kulakovskiy et al.(2013)
FOXP2_MOUSE.H11MO.0.A 		0.829 1.000
FOXP1
M00836_2.00 		Homo sapiens
NRTMAACANN
NNTGTTKAYN		 PBM
Gabut et al.(2011)
pEX0123 		0.751 0.901
FOXP1
M00837_2.00 		Homo sapiens
DGTAAACAA
TTGTTTACH		 PBM
Gabut et al.(2011)
pEX0124 		0.751 0.901
FOXP1
M01976_2.00 		Homo sapiens
RTAAACAA
TTGTTTAY		 PBM
Weirauch et al.(2014)
pTH5656 		0.751 0.901
Foxp1
M00793_2.00 		Mus musculus
NRTMAAYAN
NTRTTKAYN		 PBM
Weirauch et al.(2013)
pTH3855 		0.751 0.901
FOXP1
M04811_2.00 		Homo sapiens
NTGTTTRYNRTNNNNNNBNAYRVWMAACAN
NTGTTKWBYRTNVNNNNNNAYNRYAAACAN		 SELEX
Yin et al.(2017)
FOXP1_eDBD_HT-SELEX 		0.751 0.901
FOXP1
M08115_2.00 		Homo sapiens
NDGTAAACAVNN
NNBTGTTTACHN		 ChIP-seq
Mathelier et al.(2014)
MA0481.2 		0.751 0.901
FOXP1
M09086_2.00 		Homo sapiens
RKAAACAVM
KBTGTTTMY		 Misc
Kulakovskiy et al.(2013)
FOXP1_HUMAN.H11MO.0.A 		0.751 0.901
FOXP1
M09541_2.00 		Homo sapiens
NDGTAAACAVNN
NNBTGTTTACHN		 Misc
Heinz et al.(2010)
H9-FOXP1_GSE31006 		0.751 0.901
FOXP1
M10536_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$FOXP1_01 		0.751 0.901
FOXP1
M04812_2.00 		Homo sapiens
NTGTTTRYBRTNNNNNNBNAYRVWMAACAH
DTGTTKWBYRTNVNNNNNNAYVRYAAACAN		 SELEX
Yin et al.(2017)
FOXP1_eDBD_Methyl-HT-SELEX 		0.751 0.901
FoxP
M03753_2.00 		Drosophila melanogaster
AAACAACAACAA
TTGTTGTTGTTT		 SELEX
Nitta et al.(2015)
CG16899_1 		0.725 0.728
FoxP
M06201_2.00 		Drosophila melanogaster
VRTAAACAA
TTGTTTAYB		 B1H
Zhu et al.(2011)
CG16899_SANGER_5_FBgn0037735 		0.725 0.728
FoxP
M06202_2.00 		Drosophila melanogaster
VNNVBBAAAAAAAD
HTTTTTTTVVBNNB		 B1H
Zhu et al.(2011)
CG2052_SANGER_2.5_FBgn0039905 		0.725 0.728
FoxP
M06203_2.00 		Drosophila melanogaster
NNNNNRAAAAAAWNN
NNWTTTTTTYNNNNN		 B1H
Zhu et al.(2011)
CG2052_SOLEXA_2.5_FBgn0039905 		0.725 0.728
SPU_025010
M01988_2.00 		Strongylocentrotus purpuratus
NNVNHHAYAN
NTRTDDNBNN		 PBM
Weirauch et al.(2014)
pTH6641 		0.667 0.457
For this family, TFs with SR scores > 0.664 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000265436 Forkhead 504 588
ENSP00000377129 Forkhead 412 496
ENSP00000377130 Forkhead 329 403
ENSP00000377132 Forkhead 504 588
ENSP00000377135 Forkhead 483 567
ENSP00000385069 Forkhead 521 605
ENSP00000386200 Forkhead 529 613

Links

Other Forkhead family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

397 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action