NKX2-2 (Equus caballus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSECAG00000018977 T209165_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nkx2-2
M00438_2.00 		Mus musculus
NNNRAGDRN
NYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-2_2823 		0.867 1.000
Nkx2-2
M09190_2.00 		Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN		 Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A 		0.867 1.000
NKX2-2
M10681_2.00 		Homo sapiens
WTAAGTRBTT
AAVYACTTAW		 Transfac
Matys et al.(2006)
V$NKX22_01 		0.867 1.000
NKX2-2
M10682_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3_01 		0.867 1.000
NKX2-2
M10683_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3 		0.867 1.000
vnd
M06551_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Mathelier et al.(2014)
MA0253.1 		0.850 0.965
vnd
M06377_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986 		0.850 0.965
vnd
M06378_2.00 		Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM		 B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986 		0.850 0.965
vnd
M06379_2.00 		Drosophila melanogaster
BTBAAGTR
YACTTVAV		 B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986 		0.850 0.965
vnd
M09683_2.00 		Drosophila melanogaster
TCAAGTGB
VCACTTGA		 Misc
Kulakovskiy et al.(2009)
vnd 		0.850 0.965
Nkx2-9
M00520_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-9_3082 		0.843 0.912
Nkx2-9
M00800_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Weirauch et al.(2013)
pTH2842 		0.843 0.912
Nkx2-9
M09215_2.00 		Mus musculus
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C 		0.843 0.912
NKX2-8
M00302_2.00 		Homo sapiens
NNRAGDRB
VYHCTYNN		 PBM
Barrera et al.(2016)
NKX2-8_REF 		0.811 0.912
NKX2-8
M05149_2.00 		Homo sapiens
BTSRAGTGBN
NVCACTYSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX 		0.811 0.912
NKX2-8
M09145_2.00 		Homo sapiens
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C 		0.811 0.912
NKX2-8
M05150_2.00 		Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1 		0.811 0.912
NKX2-8
M05151_2.00 		Homo sapiens
BTSAAGTGBN
NVCACTTSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2 		0.811 0.912
NKX2-8
M05152_2.00 		Homo sapiens
BTBAACGAB
VTCGTTVAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3 		0.811 0.912
NKX2-8
M00301_2.00 		Homo sapiens
NNRAKDRB
VYHMTYNN		 PBM
Barrera et al.(2016)
NKX2-8_A94T 		0.811 0.895
ceh-22
M00376_2.00 		Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW		 PBM
Berger et al.(2006)
Ceh-22 		0.807 0.860
scro
M03854_2.00 		Drosophila melanogaster
NNBRMGTGB
VCACKYVNN		 SELEX
Nitta et al.(2015)
scro_1 		0.799 0.895
Nkx2-1
M00385_2.00 		Mus musculus
NNRAGDRN
NYHCTYNN		 PBM
Berger et al.(2008)
Titf1_1722 		0.798 0.895
Nkx2-4
M00514_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-4_3074 		0.798 0.895
NKX2-1
M09146_2.00 		Homo sapiens
BTKGAGWGBN
NVCWCTCMAV		 Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A 		0.798 0.895
Nkx2-1
M09171_2.00 		Mus musculus
NBTKGAGWGB
VCWCTCMAVN		 Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A 		0.798 0.895
Nkx2-1
M09563_2.00 		Mus musculus
BTBRAGWGBH
DVCWCTYVAV		 Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252 		0.798 0.895
NKX2-1
M10694_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TITF1_Q3 		0.798 0.895
NKX2-1
M10695_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5_01 		0.798 0.895
NKX2-1
M10696_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5 		0.798 0.895
NKX2-1
M10697_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q6 		0.798 0.895
ceh-24
M02181_2.00 		Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN		 PBM
Weirauch et al.(2014)
pTH6327 		0.784 0.825
NKX2-5
M00323_2.00 		Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN		 PBM
Barrera et al.(2016)
NKX2-5_REF 		0.742 0.789
Nkx2-5
M00404_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-5_3436 		0.742 0.789
NKX2-5
M05346_2.00 		Homo sapiens
BHYAAGTGBN
NVCACTTRDV		 SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX 		0.742 0.789
Nkx2-5
M02686_2.00 		Mus musculus
WTAAKWK
MWMTTAW		 SELEX
Mathelier et al.(2014)
MA0063.1 		0.742 0.789
Nkx2-5
M08136_2.00 		Mus musculus
SYTGAGWGSYH
DRSCWCTCARS		 ChIP-seq
Mathelier et al.(2014)
MA0503.1 		0.742 0.789
NKX2-5
M09163_2.00 		Homo sapiens
BKRAGWGV
BCWCTYMV		 Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B 		0.742 0.789
Nkx2-5
M09177_2.00 		Mus musculus
NBYBRAGTGS
SCACTYVRVN		 Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A 		0.742 0.789
Nkx2-5
M09567_2.00 		Mus musculus
HBRAGWGBNN
NNVCWCTYVD		 Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529 		0.742 0.789
NKX2-5
M10742_2.00 		Homo sapiens
TYAAGTG
CACTTRA		 Transfac
Matys et al.(2006)
V$NKX25_01 		0.742 0.789
NKX2-5
M10743_2.00 		Homo sapiens
CWTAATTV
BAATTAWG		 Transfac
Matys et al.(2006)
V$NKX25_02 		0.742 0.789
NKX2-5
M10744_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q5 		0.742 0.789
NKX2-5
M10745_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q6 		0.742 0.789
NKX2-5
M05347_2.00 		Homo sapiens
BTYAAGTGGN
NCCACTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1 		0.742 0.789
NKX2-5
M05348_2.00 		Homo sapiens
BTYAACGAB
VTCGTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2 		0.742 0.789
NKX2-5
M00322_2.00 		Homo sapiens
NNNRNNN
NNNYNNN		 PBM
Barrera et al.(2016)
NKX2-5_R190C 		0.742 0.772
NKX2-5
M00324_2.00 		Homo sapiens
NHNNNNN
NNNNNDN		 PBM
Barrera et al.(2016)
NKX2-5_T178M 		0.742 0.772
Nkx2-3
M00497_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-3_3435 		0.741 0.807
NKX2-3
M05042_2.00 		Homo sapiens
NNBAAGTGBN
NVCACTTVNN		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX 		0.741 0.807
NKX2-3
M05045_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX 		0.741 0.807
NKX2-3
M05043_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05044_2.00 		Homo sapiens
SDYAACGHB
VDCGTTRHS		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-3
M05046_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05047_2.00 		Homo sapiens
SWYAACSHB
VDSGTTRWS		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-5
M00321_2.00 		Homo sapiens
HNAAGTRBNN
NNVYACTTND		 PBM
Barrera et al.(2016)
NKX2-5_R161P 		0.737 0.772
ceh-28
M08210_2.00 		Caenorhabditis elegans
AATCGATW
WATCGATT		 ChIP-seq
Contrino et al.(2012)
Mw138 		0.736 0.649
Nkx2-6
M00496_2.00 		Mus musculus
HYAAGTRBNN
NNVYACTTRD		 PBM
Berger et al.(2008)
Nkx2-6_3437 		0.718 0.754
tin
M00559_2.00 		Drosophila melanogaster
NWYAAGTGGNN
NNCCACTTRWN		 PBM
Busser et al.(2012a)
Tin 		0.718 0.632
tin
M03809_2.00 		Drosophila melanogaster
BTYAAGTGSN
NSCACTTRAV		 SELEX
Nitta et al.(2015)
tin_1 		0.718 0.632
tin
M06284_2.00 		Drosophila melanogaster
BTYAAGTG
CACTTRAV		 B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110 		0.718 0.632
tin
M06285_2.00 		Drosophila melanogaster
BCTCAAGTGSVN
NBSCACTTGAGV		 B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110 		0.718 0.632
tin
M06286_2.00 		Drosophila melanogaster
BWYAAGTR
YACTTRWV		 B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110 		0.718 0.632
tin
M08421_2.00 		Drosophila melanogaster
DBTCRAGTGS
SCACTYGAVH		 ChIP-chip
Mathelier et al.(2014)
MA0247.2 		0.718 0.632
NKX2-5
M00320_2.00 		Homo sapiens
NHBAAKWRN
NYWMTTVDN		 PBM
Barrera et al.(2016)
NKX2-5_K183E 		0.709 0.772
Q24782_9CNID
M02206_2.00 		Eleutheria dichotoma
TTAATTAA
TTAATTAA		 PBM
Weirauch et al.(2014)
pTH5486 		0.613 0.491
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSECAP00000016451 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Equus caballus TFs

821 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
AAEL003602 Aedes aegypti AAEL003602 N 0.000
AALB005765 Anopheles albimanus AALB005765 N 0.000
AARA007771 Anopheles arabiensis AARA007771 N 0.000
AATE006171 Anopheles atroparvus AATE006171 N 0.000
ACEP12467 Atta cephalotes ACEP12467 N 0.000
ACHR001790 Anopheles christyi ACHR001790 N 0.000
ACUA006984 Anopheles culicifacies ACUA006984 N 0.000
ACYPI007962 Acyrthosiphon pisum ACYPI007962 N 0.000
ADIR008055 Anopheles dirus ADIR008055 N 0.000
AEPI001699 Anopheles epiroticus AEPI001699 N 0.000
AFAF012484 Anopheles farauti AFAF012484 N 0.000
AFUN008026 Anopheles funestus AFUN008026 N 0.000
AGAP007109 Anopheles gambiae AGAP007109 N 0.000
AMAM024265 Anopheles maculatus AMAM024265 N 0.000
AMEC009079 Anopheles melas AMEC009079 N 0.000
AMEC019433 Anopheles melas AMEC019433 N 0.000
AMEM014597 Anopheles merus AMEM014597 N 0.000
AMIN011248 Anopheles minimus AMIN011248 N 0.000
AQUA002036 Anopheles quadriannulatus AQUA002036 N 0.000
ASIS021384 Anopheles sinensis ASIS021384 N 0.000
ASTEI06883 Anopheles stephensi ASTEI06883 N 0.000
BGIBMGA012741 Bombyx mori BGIBMGA012741 N 0.000
CapteG221467 Capitella teleta CapteG221467 N 0.000
Cflo_02233--XP_001120809.1_APIME Camponotus floridanus Cflo_02233--XP_001120809.1_APIME N 0.000
CLEC010738 Cimex lectularius CLEC010738 N 0.000
CPIJ004963 Culex quinquefasciatus CPIJ004963 N 0.000
CpipJ_CPIJ004963 Culex pipiens CpipJ_CPIJ004963 N 0.000
DAPPUDRAFT_28712 Daphnia pulex DAPPUDRAFT_28712 N 0.000
PRDM8 Anolis carolinensis ENSACAG00000010106 N 0.000
ENSAMXG00000020060 Astyanax mexicanus ENSAMXG00000020060 N 0.000
PRDM8 Canis familiaris ENSCAFG00000008881 N 0.000
PRDM8 Callithrix jacchus ENSCJAG00000015064 N 0.000
PRDM8 Cavia porcellus ENSCPOG00000019738 N 0.000
ENSCSAG00000004478 Chlorocebus sabaeus ENSCSAG00000004478 N 0.000
prdm8b Danio rerio ENSDARG00000054683 N 0.000
PRDM8 Dasypus novemcinctus ENSDNOG00000011667 N 0.000
ENSECAG00000017767 Equus caballus ENSECAG00000017767 N 0.000
ENSFCAG00000026794 Felis catus ENSFCAG00000026794 N 0.000
PRDM8 Homo sapiens ENSG00000152784 N 0.000
ENSGALG00000026560 Gallus gallus ENSGALG00000026560 N 0.000
PRDM8 Gorilla gorilla ENSGGOG00000007501 N 0.000
ENSLACG00000001866 Latimeria chalumnae ENSLACG00000001866 N 0.000
ENSLOCG00000007226 Lepisosteus oculatus ENSLOCG00000007226 N 0.000
ENSMEUG00000015872 Macropus eugenii ENSMEUG00000015872 N 0.000
PRDM8 Myotis lucifugus ENSMLUG00000030190 N 0.000
PRDM8 Macaca mulatta ENSMMUG00000003338 N 0.000
PRDM8 Monodelphis domestica ENSMODG00000020789 N 0.000
ENSMPUG00000006558 Mustela putorius furo ENSMPUG00000006558 N 0.000
Prdm8 Mus musculus ENSMUSG00000035456 N 0.000
ENSNLEG00000008504 Nomascus leucogenys ENSNLEG00000008504 N 0.000
ENSOARG00000018972 Ovis aries ENSOARG00000018972 N 0.000
ENSOGAG00000026262 Otolemur garnettii ENSOGAG00000026262 N 0.000
ENSONIG00000014038 Oreochromis niloticus ENSONIG00000014038 N 0.000
prdm8b Oryzias latipes ENSORLG00000017786 N 0.000
ENSP00000406998 Macaca fascicularis ENSP00000406998 N 0.000
ENSPANG00000024349 Papio anubis ENSPANG00000024349 N 0.000
PRDM8 Procavia capensis ENSPCAG00000001081 N 0.000
ENSPFOG00000011716 Poecilia formosa ENSPFOG00000011716 N 0.000
ENSPMAG00000005756 Petromyzon marinus ENSPMAG00000005756 N 0.000
ENSPPYG00000014879 Pongo abelii ENSPPYG00000014879 N 0.000
Prdm8 Rattus norvegicus ENSRNOG00000002004 N 0.000
PRDM8 Sorex araneus ENSSARG00000009823 N 0.000
ENSSHAG00000018147 Sarcophilus harrisii ENSSHAG00000018147 N 0.000
ENSSTOG00000015688 Ictidomys tridecemlineatus ENSSTOG00000015688 N 0.000
PRDM8 Tupaia belangeri ENSTBEG00000006138 N 0.000
prdm8b Tetraodon nigroviridis ENSTNIG00000016712 N 0.000
prdm8b Takifugu rubripes ENSTRUG00000001003 N 0.000
ENSXMAG00000009993 Xiphophorus maculatus ENSXMAG00000009993 N 0.000
CG13287 Drosophila melanogaster FBgn0035643 N 0.000
GA12173 Drosophila pseudoobscura FBgn0072221 N 0.000
GF23998 Drosophila ananassae FBgn0100992 N 0.000
GG15296 Drosophila erecta FBgn0107548 N 0.000
GH14523 Drosophila grimshawi FBgn0121999 N 0.000
GH25273 Drosophila grimshawi FBgn0132728 N 0.000
GI13299 Drosophila mojavensis FBgn0136056 N 0.000
GL21034 Drosophila persimilis FBgn0158629 N 0.000
GM14727 Drosophila sechellia FBgn0169648 N 0.000
GD13907 Drosophila simulans FBgn0185603 N 0.000
GJ12068 Drosophila virilis FBgn0199320 N 0.000
GK16660 Drosophila willistoni FBgn0218662 N 0.000
GE21517 Drosophila yakuba FBgn0238774 N 0.000
GB51047 Apis mellifera GB51047 N 0.000
HHAL003310-PA Halyomorpha halys HHAL003310-PA N 0.000
HMEL017852 Heliconius melpomene HMEL017852 N 0.000
Hsal_04139--XP_001120809.1_APIME Harpegnathos saltator Hsal_04139--XP_001120809.1_APIME N 0.000
ISCW009928 Ixodes scapularis ISCW009928 N 0.000
KGM_11907 Danaus plexippus KGM_11907 N 0.000
L798_05037 Zootermopsis nevadensis L798_05037 N 0.000
LCUP008185 Lucilia cuprina LCUP008185 N 0.000
LotgiG69958 Lottia gigantea LotgiG69958 N 0.000
MCINX010301 Melitaea cinxia MCINX010301 N 0.000
MDOA007546 Musca domestica MDOA007546 N 0.000
NV17890 Nasonia vitripennis NV17890 N 0.000
Ocbimv22006527m.g Octopus bimaculoides Ocbimv22006527m.g N 0.000
Ogr08710 Ophisaurus gracilis Ogr08710 N 0.000
PHUM271650 Pediculus humanus PHUM271650 N 0.000
PPAI006396 Phlebotomus papatasi PPAI006396 N 0.000
Pvit_15291 Pogona vitticeps Pvit_15291 N 0.000
SINV25005 Solenopsis invicta SINV25005 N 0.000
SMAR006435 Strigamia maritima SMAR006435 N 0.000
TC013073 Tribolium castaneum TC013073 N 0.000
tetur11g03890 Tetranychus urticae tetur11g03890 N 0.000
prdm8 Xenopus tropicalis XB-GENE-984391 N 0.000