IRF8 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000140968 T244082_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF8
M03335_2.00
Homo sapiens
HCGAAACYGAAACY

RGTTTCRGTTTCGD
SELEX
Jolma et al.(2013)
IRF8_1
(Direct) (Direct)
IRF8
M03336_2.00
Homo sapiens
HCGAAACCGAAACT

AGTTTCGGTTTCGD
SELEX
Jolma et al.(2013)
IRF8_2
(Direct) (Direct)
IRF8
M05541_2.00
Homo sapiens
NYGAAASYGAAASHN

NDSTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX
(Direct) (Direct)
IRF8
M05542_2.00
Homo sapiens
NYGAAASYGAAASYN

NRSTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
IRF8
M05543_2.00
Homo sapiens
NCGAAACYGAAACYN

NRGTTTCRGTTTCGN
SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX
(Direct) (Direct)
IRF8
M05544_2.00
Homo sapiens
NYGAAASYGAAACYD

HRGTTTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX
(Direct) (Direct)
IRF8
M09236_2.00
Homo sapiens
NDDDRRGGAASTGAAASYNN

NNRSTTTCASTTCCYYHHHN
Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B
(Direct) (Direct)
IRF8
M10890_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ICSBP_Q6
(Direct) (Direct)
IRF8
M10891_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF8_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Irf8
M09246_2.00
Mus musculus
NDDDRRGGAASTGAAASYNN

NNRSTTTCASTTCCYYHHHN
Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A
0.949 0.949
Irf4
M00175_2.00
Mus musculus
NNNYGAWASN

NSTWTCRNNN
PBM
Badis et al.(2009)
Irf4_3476
0.817 0.817
IRF4
M03334_2.00
Homo sapiens
HCGAAACCGAAACYW

WRGTTTCGGTTTCGD
SELEX
Jolma et al.(2013)
IRF4_1
0.817 0.817
IRF4
M05539_2.00
Homo sapiens
NYGAAACYGAAACYN

NRGTTTCRGTTTCRN
SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX
0.817 0.817
IRF4
M07978_2.00
Homo sapiens
DNDVNNGWWVTGAVWVWN

NWBWBTCABWWCNNBHNH
ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha
0.817 0.817
IRF4
M09235_2.00
Homo sapiens
NDWDRRGGAASTGARAVH

DBTYTCASTTCCYYHWHN
Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A
0.846 0.846
Irf4
M09243_2.00
Mus musculus
NDAWVVRGAASTGARAVH

DBTYTCASTTCYBBWTHN
Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A
0.846 0.846
IRF4
M09595_2.00
Homo sapiens
HNYGAAASYD

HRSTTTCRND
Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465
0.846 0.846
IRF4
M10885_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_07
0.846 0.846
IRF4
M10886_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_08
0.846 0.846
IRF4
M10887_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q5_01
0.817 0.817
IRF4
M10888_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q5
0.817 0.817
IRF4
M10889_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF4_Q6
0.817 0.817
IRF4
M05540_2.00
Homo sapiens
NYGAAASYGAWASHN

NDSTWTCRSTTTCRN
SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX
0.817 0.817
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000268638 IRF 9 113
ENSP00000455048 IRF 1 56
ENSP00000455784 IRF 9 113
ENSP00000455816 IRF 9 47
ENSP00000456992 IRF 9 113
ENSP00000458047 IRF 9 113

Links

Other IRF family TFs
Other Homo sapiens TFs

166 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AGABI2DRAFT_224213 Agaricus bisporus AGABI2DRAFT_224213 N 0.000
BOTBODRAFT_50846 Botryobasidium botryosum BOTBODRAFT_50846 N 0.000
CERSUDRAFT_89102 Ceriporiopsis subvermispora CERSUDRAFT_89102 N 0.000
CY34DRAFT_21340 Suillus luteus CY34DRAFT_21340 N 0.000
estExt_Genewise1.C_70735 Heterobasidion annosum estExt_Genewise1.C_70735 N 0.000
FIBRA_04563 Fibroporia radiculosa FIBRA_04563 N 0.000
FOMPIDRAFT_1031471 Fomitopsis pinicola FOMPIDRAFT_1031471 N 0.000
GALMADRAFT_238181 Galerina marginata GALMADRAFT_238181 N 0.000
GLOTRDRAFT_66280 Gloeophyllum trabeum GLOTRDRAFT_66280 N 0.000
HETIRDRAFT_384208 Heterobasidion irregulare HETIRDRAFT_384208 N 0.000
HYDPIDRAFT_182671 Hydnomerulius pinastri HYDPIDRAFT_182671 N 0.000
JAAARDRAFT_30454 Jaapia argillacea JAAARDRAFT_30454 N 0.000
K443DRAFT_672892 Laccaria amethystina K443DRAFT_672892 N 0.000
LACBIDRAFT_309255 Laccaria bicolor LACBIDRAFT_309255 N 0.000
M404DRAFT_248099 Pisolithus tinctorius M404DRAFT_248099 N 0.000
M407DRAFT_30153 Tulasnella calospora M407DRAFT_30153 N 0.000
M408DRAFT_198102 Serendipita vermifera M408DRAFT_198102 N 0.000
M413DRAFT_444187 Hebeloma cylindrosporum M413DRAFT_444187 N 0.000
M422DRAFT_55406 Sphaerobolus stellatus M422DRAFT_55406 N 0.000
Moror_12409 Moniliophthora roreri Moror_12409 N 0.000
PAXRUDRAFT_143066 Paxillus rubicundulus PAXRUDRAFT_143066 N 0.000
PHACADRAFT_262394 Phanerochaete carnosa PHACADRAFT_262394 N 0.000
PHLGIDRAFT_126149 Phlebiopsis gigantea PHLGIDRAFT_126149 N 0.000
PIIN_00682 Piriformospora indica PIIN_00682 N 0.000
PILCRDRAFT_812975 Piloderma croceum PILCRDRAFT_812975 N 0.000
PISMIDRAFT_684265 Pisolithus microcarpus PISMIDRAFT_684265 N 0.000
PLEOSDRAFT_1044878 Pleurotus ostreatus PLEOSDRAFT_1044878 N 0.000
SCHCODRAFT_81726 Schizophyllum commune SCHCODRAFT_81726 N 0.000
SERLA73DRAFT_55337 Serpula lacrymans SERLA73DRAFT_55337 N 0.000