CIS-BP Database: Catalog of Inferred Sequence Binding Preferences

TF Information

NR5A1 *(Homo sapiens)* Nuclear receptor
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00105 (zf-C4)	IPR001628	ENSG00000136931	T303227_2.00	Ensembl (2018-Dec-8)	Link out
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
NR5A1 M05613_2.00	Homo sapiens	NNCAAGGYCRN	NYGRCCTTGNN	SELEX Yin et al.(2017) NR5A1_FL_HT-SELEX	(Direct)	(Direct)
NR5A1 M05614_2.00	Homo sapiens	NNSAAGGHCRN	NYGDCCTTSNN	SELEX Yin et al.(2017) NR5A1_FL_Methyl-HT-SELEX	(Direct)	(Direct)
NR5A1 M11142_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SF1_Q5_01	(Direct)	(Direct)
NR5A1 M11143_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SF1_Q5	(Direct)	(Direct)
NR5A1 M11144_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SF1_Q6_01	(Direct)	(Direct)
NR5A1 M11145_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$SF1_Q6	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Nr5a1 M09322_2.00	Mus musculus	NBYCAAGGYCA	TGRCCTTGRVN	Misc Kulakovskiy et al.(2013) STF1_MOUSE.H11MO.0.B	0.993	1.000
NR5A2 M05589_2.00	Homo sapiens	YCAAGGYCRYGRCCTTSR	YSAAGGYCRYGRCCTTGR	SELEX Yin et al.(2017) NR5A2_eDBD_HT-SELEX_1	0.989	0.886
NR5A2 M05590_2.00	Homo sapiens	NYCAAGGTCAH	DTGACCTTGRN	SELEX Yin et al.(2017) NR5A2_eDBD_HT-SELEX_2	0.989	0.886
NR5A2 M05591_2.00	Homo sapiens	YGRCCTTSVNYSAAGGYCR	YGRCCTTSRNBSAAGGYCR	SELEX Yin et al.(2017) NR5A2_eDBD_HT-SELEX_3	0.989	0.886
NR5A2 M09271_2.00	Homo sapiens	NBYCAAGGYCA	TGRCCTTGRVN	Misc Kulakovskiy et al.(2013) NR5A2_HUMAN.H11MO.0.B	0.989	0.886
NR5A2 M11126_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$LRH1_Q5_01	0.989	0.886
NR5A2 M11127_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$LRH1_Q5	0.989	0.886
NR5A2 M11128_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$LRH1_Q6	0.989	0.886
NR5A2 M05592_2.00	Homo sapiens	YCAAGGYCRYGACCTTSR	YSAAGGTCRYGRCCTTGR	SELEX Yin et al.(2017) NR5A2_eDBD_Methyl-HT-SELEX_1	0.989	0.886
NR5A2 M05593_2.00	Homo sapiens	NYCAAGGTCRH	DYGACCTTGRN	SELEX Yin et al.(2017) NR5A2_eDBD_Methyl-HT-SELEX_2	0.989	0.886
NR5A2 M05594_2.00	Homo sapiens	YGRCCTTSVNBSAAGGYCR	YGRCCTTSVNBSAAGGYCR	SELEX Yin et al.(2017) NR5A2_eDBD_Methyl-HT-SELEX_3	0.989	0.886
Nr5a2 M00816_2.00	Mus musculus	VAAGGTCR	YGACCTTB	PBM Weirauch et al.(2013) pTH3468	0.987	0.843
Nr5a2 M08158_2.00	Mus musculus	VRDBTCAAGGYCANN	NNTGRCCTTGAVHYB	ChIP-seq Mathelier et al.(2014) MA0505.1	0.987	0.843
Nr5a2 M09320_2.00	Mus musculus	NBYCAAGGYCA	TGRCCTTGRVN	Misc Kulakovskiy et al.(2013) NR5A2_MOUSE.H11MO.0.A	0.987	0.843
Nr5a2 M09616_2.00	Mus musculus	BYCAAGGYCA	TGRCCTTGRV	Misc Heinz et al.(2010) Pancreas-LRH1_GSE34295	0.987	0.843
Nr5a2 M09615_2.00	Mus musculus	BYCAAGGYCA	TGRCCTTGRV	Misc Heinz et al.(2010) mES-Nr5a2_GSE19019	0.987	0.843
ftz-f1 M02407_2.00	Drosophila melanogaster	RRGGTCAH	DTGACCYY	PBM Weirauch et al.(2014) pTH5709	0.982	0.857
ftz-f1 M06417_2.00	Drosophila melanogaster	MMRKYYSAAGGWCRCYGM	KCRGYGWCCTTSRRMYKK	B1H Zhu et al.(2011) ftz-f1_FlyReg_FBgn0001078	0.982	0.857
ftz-f1 M06418_2.00	Drosophila melanogaster	AAGGTCA	TGACCTT	B1H Zhu et al.(2011) ftz-f1_SANGER_5_FBgn0001078	0.982	0.857
nhr-25 M08226_2.00	Caenorhabditis elegans	MAAGGTCA	TGACCTTK	ChIP-seq Contrino et al.(2012) Mw160	0.965	0.743
Hr39 M03942_2.00	Drosophila melanogaster	CAAGGHCRN	NYGDCCTTG	SELEX Nitta et al.(2015) Hr39_1	0.953	0.600
Hr39 M03943_2.00	Drosophila melanogaster	CAAGGYCRH	DYGRCCTTG	SELEX Nitta et al.(2015) Hr39_2	0.953	0.600
Nr2f6 M00811_2.00	Mus musculus	NRRGGTCANN	NNTGACCYYN	PBM Weirauch et al.(2013) pTH2193	0.831	0.543
Nr2f6 M03419_2.00	Mus musculus	RAGGTCAADAGGTCA	TGACCTHTTGACCTY	SELEX Jolma et al.(2013) Nr2f6_1	0.831	0.543
Nr2f6 M03420_2.00	Mus musculus	RRGGTCAAAGGTCA	TGACCTTTGACCYY	SELEX Jolma et al.(2013) Nr2f6_2	0.831	0.543
usp M03934_2.00	Drosophila melanogaster	ARRGGTCAAAGGTCA	TGACCTTTGACCYYT	SELEX Nitta et al.(2015) usp_1	0.829	0.586
usp M06426_2.00	Drosophila melanogaster	HRRGGTCAH	DTGACCYYD	B1H Zhu et al.(2011) usp_SANGER_5_FBgn0003964	0.829	0.586
usp M02709_2.00	Drosophila melanogaster	GGGGTCACSN	NSGTGACCCC	SELEX Mathelier et al.(2014) MA0016.1	0.829	0.586
usp M09689_2.00	Drosophila melanogaster	KRGGTCACG	CGTGACCYM	Misc Kulakovskiy et al.(2009) usp	0.829	0.586
usp M11191_2.00	Drosophila melanogaster	GRGGTCAYS	SRTGACCYC	Transfac Matys et al.(2006) I$CF1_01	0.829	0.586
usp M11192_2.00	Drosophila melanogaster	GGGGTCAYS	SRTGACCCC	Transfac Matys et al.(2006) I$CF1_02	0.829	0.586
Rxra M00181_2.00	Mus musculus	NRRGGTCANN	NNTGACCYYN	PBM Badis et al.(2009) Rxra_1035	0.803	0.557
RXRA M03408_2.00	Homo sapiens	RRGGTCAAAGGTCA	TGACCTTTGACCYY	SELEX Jolma et al.(2013) RXRA_1	0.803	0.557
RXRA M03409_2.00	Homo sapiens	RRGGTCATGACCYY	RRGGTCATGACCYY	SELEX Jolma et al.(2013) RXRA_2	0.803	0.557
RXRA M03410_2.00	Homo sapiens	RRGGTCAAAGGTCA	TGACCTTTGACCYY	SELEX Jolma et al.(2013) RXRA_3	0.803	0.557
RXRA M03411_2.00	Homo sapiens	RRGGTCATGACCYY	RRGGTCATGACCYY	SELEX Jolma et al.(2013) RXRA_4	0.803	0.557
Rxra M03421_2.00	Mus musculus	RRGGTCAAAGGTCA	TGACCTTTGACCYY	SELEX Jolma et al.(2013) Rxra_1	0.803	0.557
Rxra M03422_2.00	Mus musculus	RGGTCATGACCY	RGGTCATGACCY	SELEX Jolma et al.(2013) Rxra_2	0.803	0.557
RXRA M05671_2.00	Homo sapiens	RRGGTCAAAGGTCAN	NTGACCTTTGACCYY	SELEX Yin et al.(2017) RXRA_eDBD_HT-SELEX	0.803	0.557
RXRA M05882_2.00	Homo sapiens	VRGKTBAAAGGTYRH	DYRACCTTTVAMCYB	SMiLE-seq Isakova et al.(2017) RXRa	0.803	0.557
RXRA M07993_2.00	Homo sapiens	NRRGGTCA	TGACCYYN	ChIP-seq Gerstein et al.(2012) H1-hESC_RXRA_HudsonAlpha	0.803	0.557
RXRA M07994_2.00	Homo sapiens	DDNNMRRGGTCANDN	NHNTGACCYYKNNHH	ChIP-seq Gerstein et al.(2012) HepG2_RXRA_HudsonAlpha	0.803	0.557
RXRA M09294_2.00	Homo sapiens	VDDDNDNNVRRRGGKCAVDV	BHBTGMCCYYYBNNHNHHHB	Misc Kulakovskiy et al.(2013) RXRA_HUMAN.H11MO.0.A	0.803	0.557
Rxra M09306_2.00	Mus musculus	DDVNNNNNRAGKTCAAGGYCA	TGRCCTTGAMCTYNNNNNBHH	Misc Kulakovskiy et al.(2013) RXRA_MOUSE.H11MO.0.A	0.803	0.557
RXRA M11182_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$RXRA_07	0.803	0.557
RXRA M05672_2.00	Homo sapiens	RRGGTCAAAGGTCAH	DTGACCTTTGACCYY	SELEX Yin et al.(2017) RXRA_eDBD_Methyl-HT-SELEX	0.803	0.557
Rxrg M02400_2.00	Mus musculus	VRGGTCAN	NTGACCYB	PBM Weirauch et al.(2014) pTH2880	0.800	0.543
RXRG M03375_2.00	Homo sapiens	RRGGTCAAAGGTCA	TGACCTTTGACCYY	SELEX Jolma et al.(2013) RXRG_1	0.800	0.543
RXRG M03376_2.00	Homo sapiens	RRGGTCATGACCYY	RRGGTCATGACCYY	SELEX Jolma et al.(2013) RXRG_2	0.800	0.543
RXRG M03377_2.00	Homo sapiens	GRGGTCAAAGGTCA	TGACCTTTGACCYC	SELEX Jolma et al.(2013) RXRG_3	0.800	0.543
RXRG M03378_2.00	Homo sapiens	NRGGTCATGACCYC	GRGGTCATGACCYN	SELEX Jolma et al.(2013) RXRG_4	0.800	0.543
RXRG M02746_2.00	Homo sapiens	GGTCAAAGGTCA	TGACCTTTGACC	SELEX Jolma et al.(2010) RXRG_dimer	0.800	0.543
RXRG M05615_2.00	Homo sapiens	VRGGTCAAAGGTCAN	NTGACCTTTGACCYB	SELEX Yin et al.(2017) RXRG_FL_HT-SELEX_1	0.800	0.543
RXRG M05616_2.00	Homo sapiens	RRGGTCAYGACCYY	RRGGTCRTGACCYY	SELEX Yin et al.(2017) RXRG_FL_HT-SELEX_2	0.800	0.543
RXRG M05879_2.00	Homo sapiens	RGGTBAARGGTBRND	HNYVACCYTTVACCY	SMiLE-seq Isakova et al.(2017) RXRg	0.800	0.543
RXRG M09280_2.00	Homo sapiens	NGTCAAAGGTCAH	DTGACCTTTGACN	Misc Kulakovskiy et al.(2013) RXRG_HUMAN.H11MO.0.B	0.800	0.543
Rxrg M09305_2.00	Mus musculus	VDDVDNSVNRAGKTCAAGGYCA	TGRCCTTGAMCTYNBSNHBHHB	Misc Kulakovskiy et al.(2013) RXRG_MOUSE.H11MO.0.B	0.800	0.543
RXRG M05617_2.00	Homo sapiens	DRGGTBAARGGTBRN	NYVACCYTTVACCYH	SELEX Yin et al.(2017) RXRG_FL_Methyl-HT-SELEX_1	0.800	0.543
RXRG M05618_2.00	Homo sapiens	VRGGTCAYGACCYB	VRGGTCRTGACCYB	SELEX Yin et al.(2017) RXRG_FL_Methyl-HT-SELEX_2	0.800	0.543
Rxrb M02402_2.00	Mus musculus	VRGGTCAH	DTGACCYB	PBM Weirauch et al.(2014) pTH2861	0.799	0.529
RXRB M03415_2.00	Homo sapiens	RRGGTCAAAGGTCA	TGACCTTTGACCYY	SELEX Jolma et al.(2013) RXRB_1	0.799	0.529
Rxrb M03435_2.00	Mus musculus	GRGGTCAAAGGTCA	TGACCTTTGACCYC	SELEX Jolma et al.(2013) Rxrb_1	0.799	0.529
RXRB M05681_2.00	Homo sapiens	RRGGTCAAAGGTCAN	NTGACCTTTGACCYY	SELEX Yin et al.(2017) RXRB_eDBD_HT-SELEX_1	0.799	0.529
RXRB M05682_2.00	Homo sapiens	RRGGTCAYGACCYY	RRGGTCRTGACCYY	SELEX Yin et al.(2017) RXRB_eDBD_HT-SELEX_2	0.799	0.529
RXRB M09297_2.00	Homo sapiens	DSAGGTCASD	HSTGACCTSH	Misc Kulakovskiy et al.(2013) RXRB_HUMAN.H11MO.0.C	0.799	0.529
Rxrb M09330_2.00	Mus musculus	DSAGGTCASD	HSTGACCTSH	Misc Kulakovskiy et al.(2013) RXRB_MOUSE.H11MO.0.C	0.799	0.529
RXRB M05683_2.00	Homo sapiens	RRGGTCAAAGGTCRN	NYGACCTTTGACCYY	SELEX Yin et al.(2017) RXRB_eDBD_Methyl-HT-SELEX_1	0.799	0.529
RXRB M05684_2.00	Homo sapiens	RRGGTCRYGACCYY	RRGGTCRYGACCYY	SELEX Yin et al.(2017) RXRB_eDBD_Methyl-HT-SELEX_2	0.799	0.529
Rorb M00820_2.00	Mus musculus	NRGGTCANN	NNTGACCYN	PBM Weirauch et al.(2013) pTH3469	0.778	0.557
rorb M02404_2.00	Tetraodon nigroviridis	NGAGGTCANN	NNTGACCTCN	PBM Weirauch et al.(2014) pTH6589	0.778	0.557
RORB M05677_2.00	Homo sapiens	DAWNTRGGTYAGTRGGTCAN	NTGACCYACTRACCYANWTH	SELEX Yin et al.(2017) RORB_eDBD_HT-SELEX_1	0.778	0.557
RORB M05678_2.00	Homo sapiens	NAWNKRGGTCAYGACCYMNWTN	NAWNKRGGTCRTGACCYMNWTN	SELEX Yin et al.(2017) RORB_eDBD_HT-SELEX_2	0.778	0.557
RORB M05883_2.00	Homo sapiens	AWNBRGGTCAN	NTGACCYVNWT	SMiLE-seq Isakova et al.(2017) RORb	0.778	0.557
RORB M11187_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$RORBETA_Q2	0.778	0.557
RORB M05679_2.00	Homo sapiens	DAWBTRGGTYAGTRGGTCRN	NYGACCYACTRACCYAVWTH	SELEX Yin et al.(2017) RORB_eDBD_Methyl-HT-SELEX_1	0.778	0.557
RORB M05680_2.00	Homo sapiens	NAWNKRGGTCAYGACCYMNWTN	NAWNKRGGTCRTGACCYMNWTN	SELEX Yin et al.(2017) RORB_eDBD_Methyl-HT-SELEX_2	0.778	0.557
Rorc M09324_2.00	Mus musculus	NDAWSTRRGTCA	TGACYYASWTHN	Misc Kulakovskiy et al.(2013) RORG_MOUSE.H11MO.0.B	0.777	0.571
Rorc M09617_2.00	Mus musculus	AWBTRGGTCA	TGACCYAVWT	Misc Heinz et al.(2010) EL4-RORgt.Flag_GSE56019	0.777	0.571
Hr4 M06435_2.00	Drosophila melanogaster	AAGGTCA	TGACCTT	B1H Zhu et al.(2011) Hr4_SANGER_5_FBgn0023546	0.775	0.571
Rora M00819_2.00	Mus musculus	NNRGGTCA	TGACCYNN	PBM Weirauch et al.(2013) pTH3464	0.774	0.557
RORA M03353_2.00	Homo sapiens	NMRAGGTCAAVYYVAGGTCA	TGACCTBRRBTTGACCTYKN	SELEX Jolma et al.(2013) RORA_1	0.774	0.557
RORA M03354_2.00	Homo sapiens	WAWSTRGGTYASTAGGTCA	TGACCTASTRACCYASWTW	SELEX Jolma et al.(2013) RORA_2	0.774	0.557
RORA M02705_2.00	Homo sapiens	WWVDAGGTCA	TGACCTHBWW	SELEX Mathelier et al.(2014) MA0071.1	0.774	0.557
RORA M02706_2.00	Homo sapiens	NDWAWBTAGGTCAN	NTGACCTAVWTWHN	SELEX Mathelier et al.(2014) MA0072.1	0.774	0.557
RORA M09265_2.00	Homo sapiens	VWNDRGGBCARDR	YHYTGVCCYHNWB	Misc Kulakovskiy et al.(2013) RORA_HUMAN.H11MO.0.C	0.774	0.557
Rora M09327_2.00	Mus musculus	VWNDRGGBCARDR	YHYTGVCCYHNWB	Misc Kulakovskiy et al.(2013) RORA_MOUSE.H11MO.0.C	0.774	0.557
RORA M11090_2.00	Homo sapiens	DWWWVDAGGTCAH	DTGACCTHBWWWH	Transfac Matys et al.(2006) V$RORA1_01	0.774	0.557
RORA M11091_2.00	Homo sapiens	DWAWBTAGGTCAN	NTGACCTAVWTWH	Transfac Matys et al.(2006) V$RORA2_01	0.774	0.557
RORA M11092_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$RORALPHA_Q4	0.774	0.557
RORA M11093_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$RORA_Q4	0.774	0.557
AAEL009588 M02388_2.00	Aedes aegypti	NRGGTCR	YGACCYN	PBM Weirauch et al.(2014) pTH5508	0.767	0.500
Hr46 M02406_2.00	Drosophila melanogaster	NRGGTCAN	NTGACCYN	PBM Weirauch et al.(2014) pTH6142	0.767	0.500
Hr46 M03926_2.00	Drosophila melanogaster	RGGTCAGTRGGTCA	TGACCYACTGACCY	SELEX Nitta et al.(2015) Hr46_1	0.767	0.500
Hr46 M06412_2.00	Drosophila melanogaster	AWKTGGGTYW	WRACCCAMWT	B1H Zhu et al.(2011) Hr46_FlyReg_FBgn0000448	0.767	0.500
Hr46 M06413_2.00	Drosophila melanogaster	HWNBAGGTCA	TGACCTVNWD	B1H Zhu et al.(2011) Hr46_SANGER_5_FBgn0000448	0.767	0.500
Q969A9_BOMMO M02410_2.00	Bombyx mori	VRGGTCDN	NHGACCYB	PBM Weirauch et al.(2014) pTH5516	0.761	0.557
RORC M05621_2.00	Homo sapiens	KRGGTCAYGMCCYM	KRGGKCRTGACCYM	SELEX Yin et al.(2017) RORC_eDBD_HT-SELEX_1	0.758	0.557
RORC M05622_2.00	Homo sapiens	NAWNKRGGTYANTRGGTCAN	NTGACCYANTRACCYMNWTN	SELEX Yin et al.(2017) RORC_eDBD_HT-SELEX_2	0.758	0.557
RORC M05880_2.00	Homo sapiens	NDAWNTRGGKCA	TGMCCYANWTHN	SMiLE-seq Isakova et al.(2017) RORc	0.758	0.557
RORC M09282_2.00	Homo sapiens	NDAWSTRRGTCA	TGACYYASWTHN	Misc Kulakovskiy et al.(2013) RORG_HUMAN.H11MO.0.C	0.758	0.557
RORC M05623_2.00	Homo sapiens	TRGGTCAYGACCYA	TRGGTCRTGACCYA	SELEX Yin et al.(2017) RORC_eDBD_Methyl-HT-SELEX_1	0.758	0.557
RORC M05624_2.00	Homo sapiens	NAWNTRGGTYASTAGGTCAN	NTGACCTASTRACCYANWTN	SELEX Yin et al.(2017) RORC_eDBD_Methyl-HT-SELEX_2	0.758	0.557
For this family, TFs with SR scores > 0.745* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSP00000362690	Nuclear receptor	11	80	ELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRL
ENSP00000393245	Nuclear receptor	11	80	ELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRL
ENSP00000483309	Nuclear receptor	11	80	ELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRL

Links
Other Nuclear receptor family TFs
Other *Homo sapiens* TFs

1140 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action

NR5A1 (Homo sapiens) Nuclear receptor

TF Information

Directly determined binding motifs

Motifs from related TFs

DNA Binding Domains

Links

1140 Related TFs

NR5A1 **(Homo sapiens)
Nuclear receptor**