CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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daf-12
(
Caenorhabditis elegans
)
Nuclear receptor
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00105 (zf-C4)
IPR001628
WBGene00000908
T306122_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables nuclear receptor activity; sequence-specific DNA binding activity; and steroid hormone binding activity. Involved in several processes, including determination of adult lifespan; heat acclimation; and positive regulation of dauer larval development. Located in nucleus. Is expressed in several structures, including gonad; nervous system; pharyngeal muscle cell; somatic gonad precursor; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to several human genes including NR1I2 (nuclear receptor subfamily 1 group I member 2) and VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
daf-12
M00685_2.00
Caenorhabditis elegans
NDAGTRCANN
NNTGYACTHN
PBM
Narasimhan et al.(2015)
pTH9108
(Direct)
(Direct)
daf-12
M08159_2.00
Caenorhabditis elegans
GWGYGYGYKTGYDKB
VMHRCAMRCRCRCWC
ChIP-seq
Mathelier et al.(2014)
MA0538.1
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hr96
M03940_2.00
Drosophila melanogaster
YVRGTRCANVTGYACYBR
YVRGTRCABNTGYACYBR
SELEX
Nitta et al.(2015)
Hr96_1
0.929
0.686
For this family, TFs with SR scores >
0.745
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00685_2.00
Nuclear receptor
51
120
KTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKK
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
F11A1.3a
Nuclear receptor
116
185
KTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKK
F11A1.3b
Nuclear receptor
57
126
KTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKK
F11A1.3d
Nuclear receptor
82
151
KTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKK
Links
Other
Nuclear receptor
family TFs
Other
Caenorhabditis elegans
TFs
147 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy