| NCBI Gene Info:Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; pharynx development; and positive regulation of nematode male tail tip morphogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; female reproductive organ cancer (multiple); pancreatic cancer; and primary pulmonary hypertension. Orthologous to several human genes including SMAD9 (SMAD family member 9). [provided by Alliance of Genome Resources, Apr 2022] |