TCF4 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000196628 T034340_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TCF4
M02728_2.00		 Homo sapiens
RCACCTG
CAGGTGY		 SELEX
Jolma et al.(2010)
TCF4_dimer		 (Direct) (Direct)
TCF4
M02807_2.00		 Homo sapiens
HRCACCTGBN
NVCAGGTGYD		 SELEX
Jolma et al.(2013)
TCF4_1		 (Direct) (Direct)
TCF4
M02808_2.00		 Homo sapiens
NVCACCTBBN
NVVAGGTGBN		 SELEX
Jolma et al.(2013)
TCF4_2		 (Direct) (Direct)
TCF4
M04214_2.00		 Homo sapiens
VCACCTGB
VCAGGTGB		 SELEX
Yin et al.(2017)
TCF4_eDBD_HT-SELEX		 (Direct) (Direct)
TCF4
M04215_2.00		 Homo sapiens
VCACCTGN
NCAGGTGB		 SELEX
Yin et al.(2017)
TCF4_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
TCF4
M09461_2.00		 Homo sapiens
ASWTCAAAGRVN
NBYCTTTGAWST		 Misc
Heinz et al.(2010)
Hct116-Tcf4_SRA012054		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tcf4
M01750_2.00 		Mus musculus
VCAGVTGBN
NVCABCTGB		 PBM
Weirauch et al.(2014)
pTH5101 		0.914 1.000
Tcf4
M08775_2.00 		Mus musculus
HRCACCTGB
VCAGGTGYD		 Misc
Kulakovskiy et al.(2013)
ITF2_MOUSE.H11MO.0.B 		0.914 1.000
Tcf12
M01740_2.00 		Mus musculus
NVCAYCTGB
VCAGRTGBN		 PBM
Weirauch et al.(2014)
pTH5071 		0.912 0.962
TCF12
M04137_2.00 		Homo sapiens
VCACSTGB
VCASGTGB		 SELEX
Yin et al.(2017)
TCF12_eDBD_HT-SELEX 		0.912 0.962
Tcf12
M08062_2.00 		Mus musculus
RRCAGCTGNNN
NNNCAGCTGYY		 ChIP-seq
Mathelier et al.(2014)
MA0521.1 		0.912 0.962
TCF12
M07805_2.00 		Homo sapiens
NVDSCAGSTGB
VCASCTGSHBN		 ChIP-seq
Gerstein et al.(2012)
GM12878_TCF12_HudsonAlpha 		0.912 0.962
TCF12
M07806_2.00 		Homo sapiens
VCASCTGB
VCAGSTGB		 ChIP-seq
Gerstein et al.(2012)
H1-hESC_TCF12_HudsonAlpha 		0.912 0.962
TCF12
M08731_2.00 		Homo sapiens
CMCASCTGSH
DSCAGSTGKG		 Misc
Kulakovskiy et al.(2013)
HTF4_HUMAN.H11MO.0.A 		0.912 0.962
Tcf12
M08762_2.00 		Mus musculus
VMCASCTGSH
DSCAGSTGKB		 Misc
Kulakovskiy et al.(2013)
HTF4_MOUSE.H11MO.0.A 		0.912 0.962
TCF12
M09458_2.00 		Homo sapiens
NNVCAGCTGB
VCAGCTGBNN		 Misc
Heinz et al.(2010)
GM12878-Tcf12_GSE32465 		0.912 0.962
TCF12
M09858_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HEB_Q6 		0.912 0.962
TCF12
M09859_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HTF4_Q2 		0.912 0.962
TCF12
M09860_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TCF12_01 		0.912 0.962
TCF12
M09861_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TCF12_03 		0.912 0.962
TCF12
M09862_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TCF12_05 		0.912 0.962
TCF12
M04138_2.00 		Homo sapiens
NCAYCTGN
NCAGRTGN		 SELEX
Yin et al.(2017)
TCF12_eDBD_Methyl-HT-SELEX 		0.912 0.962
Tcf3
M00753_2.00 		Mus musculus
VCACCTGBN
NVCAGGTGB		 PBM
Weirauch et al.(2013)
pTH3866 		0.912 0.885
Tcf3
M01723_2.00 		Mus musculus
NNVCACSTGB
VCASGTGBNN		 PBM
Weirauch et al.(2014)
pTH4580 		0.912 0.885
Tcf3
M00118_2.00 		Mus musculus
VCAYCTGB
VCAGRTGB		 PBM
Badis et al.(2009)
Tcfe2a_3865 		0.912 0.885
Tcf3
M09465_2.00 		Mus musculus
ABWTCAAAGS
SCTTTGAWVT		 Misc
Heinz et al.(2010)
mES-Tcf3_GSE11724 		0.884 0.923
Tcf3
M09466_2.00 		Mus musculus
VCAGCTGBNN
NNVCAGCTGB		 Misc
Heinz et al.(2010)
proBcell-E2A_GSE21978 		0.884 0.923
Tcf3
M09886_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E47_05 		0.884 0.923
TCF3
M02775_2.00 		Homo sapiens
NVCACCTGBN
NVCAGGTGBN		 SELEX
Jolma et al.(2013)
TCF3_1 		0.884 0.885
TCF3
M08710_2.00 		Homo sapiens
VVCASCTGCHN
NDGCAGSTGBB		 Misc
Kulakovskiy et al.(2013)
TFE2_HUMAN.H11MO.0.A 		0.884 0.885
TCF3
M09791_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E12_Q6 		0.884 0.885
TCF3
M09792_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E2A_Q6_01 		0.884 0.885
TCF3
M09793_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E2A_Q6_02 		0.884 0.885
TCF3
M09794_2.00 		Homo sapiens
VVVVMCACCTGCNBB
VVNGCAGGTGKBBBB		 Transfac
Matys et al.(2006)
V$E47_01 		0.884 0.885
TCF3
M09795_2.00 		Homo sapiens
NNKWRCACCTGYDNNN
NNNHRCAGGTGYWMNN		 Transfac
Matys et al.(2006)
V$E47_02 		0.884 0.885
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000346440 bHLH 569 622
ENSP00000348374 bHLH 565 618
ENSP00000381382 bHLH 671 724
ENSP00000409447 bHLH 409 462
ENSP00000439656 bHLH 523 576
ENSP00000439827 bHLH 435 488
ENSP00000440731 bHLH 545 598
ENSP00000441562 bHLH 498 551
ENSP00000445202 bHLH 541 594
ENSP00000454366 bHLH 505 558
ENSP00000454647 bHLH 435 488
ENSP00000455135 bHLH 545 598
ENSP00000455179 bHLH 435 488
ENSP00000455261 bHLH 494 547
ENSP00000455346 bHLH 540 593
ENSP00000455418 bHLH 562 615
ENSP00000455763 bHLH 405 458
ENSP00000455984 bHLH 481 534
ENSP00000456125 bHLH 509 562
ENSP00000457263 bHLH 575 628
ENSP00000457649 bHLH 565 618
ENSP00000457765 bHLH 405 458
ENSP00000478549 bHLH 481 534
ENSP00000486072 bHLH 349 402
ENSP00000486670 bHLH 569 622

Links

Other bHLH family TFs
Other Homo sapiens TFs

213 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
prkrirb Tetraodon nigroviridis ENSTNIG00000003292 D 0.000
THAP12 Gallus gallus ENSGALG00000000838 D 0.000
THAP12 Homo sapiens ENSG00000137492 D 0.000
prkrirb Oryzias latipes ENSORLG00000005427 D 0.000
prkrirb Danio rerio ENSDARG00000020964 D 0.000
ENSPCAG00000008407 Procavia capensis ENSPCAG00000008407 I 0.000
Thap12 Rattus norvegicus ENSRNOG00000053923 I 0.000
ENSPVAG00000011935 Pteropus vampyrus ENSPVAG00000011935 I 0.000
ENSPPYG00000003697 Pongo abelii ENSPPYG00000003697 I 0.000
ENSPFOG00000009414 Poecilia formosa ENSPFOG00000009414 I 0.000
ENSOCUG00000009178 Oryctolagus cuniculus ENSOCUG00000009178 I 0.000
ENSPANG00000004011 Papio anubis ENSPANG00000004011 I 0.000
ENSPANG00000003101 Papio anubis ENSPANG00000003101 I 0.000
ENSONIG00000011168 Oreochromis niloticus ENSONIG00000011168 I 0.000
THAP12 Otolemur garnettii ENSOGAG00000001569 I 0.000
ENSOCUG00000021566 Oryctolagus cuniculus ENSOCUG00000021566 I 0.000
ENSOCUG00000017323 Oryctolagus cuniculus ENSOCUG00000017323 I 0.000
Thap12 Mus musculus ENSMUSG00000030753 I 0.000
THAP12 Taeniopygia guttata ENSTGUG00000013565 I 0.000
prkrirb Takifugu rubripes ENSTRUG00000007070 I 0.000
ENSTTRG00000012793 Tursiops truncatus ENSTTRG00000012793 I 0.000
ENSXMAG00000001706 Xiphophorus maculatus ENSXMAG00000001706 I 0.000
Aan_R009109 Calypte anna Aan_R009109 I 0.000
Afo_R006000 Aptenodytes forsteri Afo_R006000 I 0.000
Brh_R010409 Buceros rhinoceros Brh_R010409 I 0.000
Cmyd_10020724 Chelonia mydas Cmyd_10020724 I 0.000
ENSMMUP00000040972 Macaca fascicularis ENSMMUP00000040972 I 0.000
ENSP00000260045-D1 Bos grunniens ENSP00000260045-D1 I 0.000
ENSP00000260045 Macaca fascicularis ENSP00000260045 I 0.000
Gfo_R003337 Geospiza fortis Gfo_R003337 I 0.000
Tal_R010930 Tyto alba Tal_R010930 I 0.000
thap12 Xenopus tropicalis XB-GENE-6073216 I 0.000
THAP12 Gorilla gorilla ENSGGOG00000024317 I 0.000
ENSAMEG00000002077 Ailuropoda melanoleuca ENSAMEG00000002077 I 0.000
ENSAMEG00000016926 Ailuropoda melanoleuca ENSAMEG00000016926 I 0.000
ENSAMXG00000002922 Astyanax mexicanus ENSAMXG00000002922 I 0.000
ENSAPLG00000010379 Anas platyrhynchos ENSAPLG00000010379 I 0.000
THAP12 Bos taurus ENSBTAG00000031609 I 0.000
THAP12 Canis familiaris ENSCAFG00000005274 I 0.000
ENSCHOG00000009417 Choloepus hoffmanni ENSCHOG00000009417 I 0.000
ENSCJAG00000012300 Callithrix jacchus ENSCJAG00000012300 I 0.000
THAP12 Cavia porcellus ENSCPOG00000013167 I 0.000
ENSCSAG00000003894 Chlorocebus sabaeus ENSCSAG00000003894 I 0.000
ENSDNOG00000031781 Dasypus novemcinctus ENSDNOG00000031781 I 0.000
ENSDORG00000007522 Dipodomys ordii ENSDORG00000007522 I 0.000
prkrirb Gasterosteus aculeatus ENSGACG00000010435 I 0.000
ENSGGOG00000023767 Gorilla gorilla ENSGGOG00000023767 I 0.000
ENSOARG00000012702 Ovis aries ENSOARG00000012702 I 0.000
ENSGGOG00000026052 Gorilla gorilla ENSGGOG00000026052 I 0.000
ENSGMOG00000010245 Gadus morhua ENSGMOG00000010245 I 0.000
ENSLACG00000001033 Latimeria chalumnae ENSLACG00000001033 I 0.000
THAP12 Loxodonta africana ENSLAFG00000011743 I 0.000
ENSLOCG00000004788 Lepisosteus oculatus ENSLOCG00000004788 I 0.000
THAP12 Meleagris gallopavo ENSMGAG00000015267 I 0.000
ENSMLUG00000000564 Myotis lucifugus ENSMLUG00000000564 I 0.000
ENSMLUG00000001341 Myotis lucifugus ENSMLUG00000001341 I 0.000
ENSMMUG00000013164 Macaca mulatta ENSMMUG00000013164 I 0.000
ENSMMUG00000022399 Macaca mulatta ENSMMUG00000022399 I 0.000
THAP12 Monodelphis domestica ENSMODG00000005315 I 0.000
THAP12 Anolis carolinensis ENSACAG00000017074 I 0.000
THAP12 Ornithorhynchus anatinus ENSOANG00000000831 I 0.000