| NCBI Gene Info:Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including mesodermal cell differentiation; neuroblast differentiation; and transdifferentiation. Located in nucleus. Is expressed in several structures, including M lineage cell; nervous system; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; Holt-Oram syndrome; IVIC syndrome; and Townes-Brocks syndrome. Orthologous to several human genes including SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022] |