CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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HSF4
(
Homo sapiens
)
HSF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00447 (HSF_DNA-bind)
IPR000232
ENSG00000102878
T240223_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HSF4
M03325_2.00
Homo sapiens
GAANNTTCBVGAA
TTCBVGAANNTTC
SELEX
Jolma et al.(2013)
HSF4_1
(Direct)
(Direct)
HSF4
M05509_2.00
Homo sapiens
VGAABVTTCKVGAAN
NTTCBMGAABVTTCB
SELEX
Yin et al.(2017)
HSF4_eDBD_HT-SELEX
(Direct)
(Direct)
HSF4
M05510_2.00
Homo sapiens
RGAABVWDCYRGAWN
NWTCYRGHWBVTTCY
SELEX
Yin et al.(2017)
HSF4_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
HSF4
M10862_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF4_Q3
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HSF1
M03329_2.00
Homo sapiens
GAANVTTCBVGAA
TTCBVGAABNTTC
SELEX
Jolma et al.(2013)
HSF1_1
0.384
0.763
HSF1
M03330_2.00
Homo sapiens
GAANRTTCBAGAA
TTCTVGAAYNTTC
SELEX
Jolma et al.(2013)
HSF1_2
0.384
0.763
HSF1
M05523_2.00
Homo sapiens
VGAABVTTCBVGAWN
NWTCBVGAABVTTCB
SELEX
Yin et al.(2017)
HSF1_eDBD_HT-SELEX
0.384
0.763
HSF1
M05525_2.00
Homo sapiens
VGAANRTTCKVGAAN
NTTCBMGAAYNTTCB
SELEX
Yin et al.(2017)
HSF1_FL_HT-SELEX
0.384
0.763
HSF1
M07977_2.00
Homo sapiens
GDCSYGGGTTCRADYCCC
GGGRHTYGAACCCRSGHC
ChIP-seq
Gerstein et al.(2012)
HepG2_HSF1_Stanford
0.384
0.763
HSF1
M09230_2.00
Homo sapiens
NRGAANNTTCYRGAA
TTCYRGAANNTTCYN
Misc
Kulakovskiy et al.(2013)
HSF1_HUMAN.H11MO.0.A
0.484
0.760
Hsf1
M09232_2.00
Mus musculus
NRGAANNTTCYRGAA
TTCYRGAANNTTCYN
Misc
Kulakovskiy et al.(2013)
HSF1_MOUSE.H11MO.0.A
0.384
0.763
HSF1
M09592_2.00
Homo sapiens
NNBBCYRGAANNTTCYRGVV
BBCYRGAANNTTCYRGVVNN
Misc
Heinz et al.(2010)
HepG2-HSF1_GSE31477
0.384
0.763
Hsf1
M09593_2.00
Mus musculus
NRGAANNTTCYRGAA
TTCYRGAANNTTCYN
Misc
Heinz et al.(2010)
Striatum-HSF1_GSE38000
0.384
0.763
HSF1
M10863_2.00
Homo sapiens
NGAAHNTTCY
RGAANDTTCN
Transfac
Matys et al.(2006)
V$HSF1_01
0.384
0.763
HSF1
M10864_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q5_01
0.384
0.763
HSF1
M10865_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q5
0.384
0.763
HSF1
M10866_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q6_01
0.384
0.763
HSF1
M10867_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF1_Q6
0.484
0.760
HSF1
M10868_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF_Q6
0.384
0.763
HSF1
M05524_2.00
Homo sapiens
RGAANRTTCYRGAWN
NWTCYRGAAYNTTCY
SELEX
Yin et al.(2017)
HSF1_eDBD_Methyl-HT-SELEX
0.384
0.763
HSF1
M05526_2.00
Homo sapiens
RGAANVTTCYRGAWN
NWTCYRGAABNTTCY
SELEX
Yin et al.(2017)
HSF1_FL_Methyl-HT-SELEX
0.384
0.763
Hsf2
M09231_2.00
Mus musculus
VGAABVTTCKVGAN
NTCBMGAABVTTCB
Misc
Kulakovskiy et al.(2013)
HSF2_MOUSE.H11MO.0.A
0.379
0.625
HSF2
M03324_2.00
Homo sapiens
GAANVTTCTAGAA
TTCTAGAABNTTC
SELEX
Jolma et al.(2013)
HSF2_1
0.372
0.615
HSF2
M02744_2.00
Homo sapiens
GAABGTTCTRGA
TCYAGAACVTTC
SELEX
Jolma et al.(2010)
HSF2_dimertrimer
0.372
0.615
HSF2
M05505_2.00
Homo sapiens
VGAABVTTCBVGAWN
NWTCBVGAABVTTCB
SELEX
Yin et al.(2017)
HSF2_eDBD_HT-SELEX
0.372
0.615
HSF2
M05507_2.00
Homo sapiens
VGAANNTTCBVGAAN
NTTCBVGAANNTTCB
SELEX
Yin et al.(2017)
HSF2_FL_HT-SELEX
0.372
0.615
HSF2
M09229_2.00
Homo sapiens
VGAABVTTCKVGAN
NTCBMGAABVTTCB
Misc
Kulakovskiy et al.(2013)
HSF2_HUMAN.H11MO.0.A
0.372
0.615
HSF2
M10859_2.00
Homo sapiens
VGAANNWTCB
VGAWNNTTCB
Transfac
Matys et al.(2006)
V$HSF2_01
0.372
0.615
HSF2
M10860_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF2_02
0.372
0.615
HSF2
M10861_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HSF2_Q6
0.372
0.615
HSF2
M05506_2.00
Homo sapiens
RGAABVTTCYRGAWN
NWTCYRGAABVTTCY
SELEX
Yin et al.(2017)
HSF2_eDBD_Methyl-HT-SELEX
0.372
0.615
HSF2
M05508_2.00
Homo sapiens
RGAABVTTCYRGAWN
NWTCYRGAABVTTCY
SELEX
Yin et al.(2017)
HSF2_FL_Methyl-HT-SELEX
0.372
0.615
hsf2
M02248_2.00
Danio rerio
NNNWGTTCTATNN
NNATAGAACWNNN
PBM
Weirauch et al.(2014)
pTH9010
0.361
0.604
HSF1
M00060_2.00
Saccharomyces cerevisiae
NNNTTCNNN
NNNGAANNN
PBM
Badis et al.(2008)
HSF1_4530
0.342
0.469
HSF1
M07489_2.00
Saccharomyces cerevisiae
HVTTCCAT
ATGGAABD
PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0319.1
0.342
0.469
HSF1
M08577_2.00
Saccharomyces cerevisiae
TTCTAGAA
TTCTAGAA
Misc
DeBoer et al.(2011)
YGL073W_1461
0.342
0.469
HSF1
M08578_2.00
Saccharomyces cerevisiae
GAANNNNNWRGAA
TTCYWNNNNNTTC
Misc
DeBoer et al.(2011)
YGL073W_411
0.342
0.469
HSF1
M08579_2.00
Saccharomyces cerevisiae
HVTTCCAT
ATGGAABD
Misc
DeBoer et al.(2011)
YGL073W_476
0.342
0.469
HSF1
M08580_2.00
Saccharomyces cerevisiae
RGAABNTTCTRGAA
TTCYAGAANVTTCY
Misc
DeBoer et al.(2011)
YGL073W_615
0.342
0.469
HSF1
M10874_2.00
Saccharomyces cerevisiae
RGAANRGAANRGAAN
NTTCYNTTCYNTTCY
Transfac
Matys et al.(2006)
F$HSF_02
0.342
0.469
HSF1
M10875_2.00
Saccharomyces cerevisiae
RGAANNTTCYNTTCY
RGAANRGAANNTTCY
Transfac
Matys et al.(2006)
F$HSF_03
0.342
0.469
HSF1
M10876_2.00
Saccharomyces cerevisiae
RGAANNTTCYRGAAN
NTTCYRGAANNTTCY
Transfac
Matys et al.(2006)
F$HSF_04
0.342
0.469
HSF1
M10877_2.00
Saccharomyces cerevisiae
NTTCYNTTCYRGAAN
NTTCYRGAANRGAAN
Transfac
Matys et al.(2006)
F$HSF_05
0.342
0.469
HSF1
M10878_2.00
Saccharomyces cerevisiae
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
F$HSF_Q6
0.342
0.469
hsf-1
M02249_2.00
Neurospora crassa
NNNTTCBDNN
NNHVGAANNN
PBM
Weirauch et al.(2014)
pTH8857
0.327
0.448
ANIA_08035
M02247_2.00
Aspergillus nidulans
NNNNTTCYRN
NYRGAANNNN
PBM
Weirauch et al.(2014)
pTH8231
0.325
0.448
hsf-1
M00682_2.00
Caenorhabditis elegans
TTCYAGAA
TTCTRGAA
PBM
Narasimhan et al.(2015)
pTH10796
0.322
0.521
For this family, TFs with SR scores >
0.318
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000264009
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000403219
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000427832
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000428161
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000428978
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000430299
HSF
1
79
GTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000430631
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000430947
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
ENSP00000463706
HSF
20
121
FLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKV
Links
Other
HSF
family TFs
Other
Homo sapiens
TFs
629 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy