IRF4 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000137265 T244081_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF4
M03334_2.00		 Homo sapiens
HCGAAACCGAAACYW
WRGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF4_1		 (Direct) (Direct)
IRF4
M05539_2.00		 Homo sapiens
NYGAAACYGAAACYN
NRGTTTCRGTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX		 (Direct) (Direct)
IRF4
M05540_2.00		 Homo sapiens
NYGAAASYGAWASHN
NDSTWTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX		 (Direct) (Direct)
IRF4
M07978_2.00		 Homo sapiens
DNDVNNGWWVTGAVWVWN
NWBWBTCABWWCNNBHNH		 ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha		 (Direct) (Direct)
IRF4
M09235_2.00		 Homo sapiens
NDWDRRGGAASTGARAVH
DBTYTCASTTCCYYHWHN		 Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A		 (Direct) (Direct)
IRF4
M09595_2.00		 Homo sapiens
HNYGAAASYD
HRSTTTCRND		 Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465		 (Direct) (Direct)
IRF4
M10885_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_07		 (Direct) (Direct)
IRF4
M10886_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_08		 (Direct) (Direct)
IRF4
M10887_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5_01		 (Direct) (Direct)
IRF4
M10888_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5		 (Direct) (Direct)
IRF4
M10889_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irf4
M00175_2.00 		Mus musculus
NNNYGAWASN
NSTWTCRNNN		 PBM
Badis et al.(2009)
Irf4_3476 		0.990 0.990
Irf4
M09243_2.00 		Mus musculus
NDAWVVRGAASTGARAVH
DBTYTCASTTCYBBWTHN		 Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A 		0.990 0.990
IRF8
M03335_2.00 		Homo sapiens
HCGAAACYGAAACY
RGTTTCRGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_1 		0.810 0.810
IRF8
M03336_2.00 		Homo sapiens
HCGAAACCGAAACT
AGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_2 		0.810 0.810
IRF8
M05541_2.00 		Homo sapiens
NYGAAASYGAAASHN
NDSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX 		0.810 0.810
IRF8
M05543_2.00 		Homo sapiens
NCGAAACYGAAACYN
NRGTTTCRGTTTCGN		 SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX 		0.810 0.810
IRF8
M09236_2.00 		Homo sapiens
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B 		0.810 0.810
IRF8
M10890_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ICSBP_Q6 		0.810 0.810
IRF8
M10891_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF8_Q6 		0.810 0.810
IRF8
M05542_2.00 		Homo sapiens
NYGAAASYGAAASYN
NRSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX 		0.810 0.810
IRF8
M05544_2.00 		Homo sapiens
NYGAAASYGAAACYD
HRGTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX 		0.810 0.810
Irf8
M09246_2.00 		Mus musculus
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A 		0.790 0.790
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000370343 IRF 23 128
ENSP00000436094 IRF 23 128

Links

Other IRF family TFs
Other Homo sapiens TFs

157 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
THITE_2112671 Thielavia terrestris THITE_2112671 N
MYCTH_2089183 Myceliophthora thermophila MYCTH_2089183 N
NechaG92211 Fusarium solani NechaG92211 N
NEUTE1DRAFT_125863 Neurospora tetrasperma NEUTE1DRAFT_125863 N
OIDMADRAFT_152191 Oidiodendron maius OIDMADRAFT_152191 N
PFICI_13325 Pestalotiopsis fici PFICI_13325 N
PODANS_1_15900 Podospora anserina PODANS_1_15900 N
S40285_05622 Stachybotrys chlorohalonata S40285_05622 N
S40288_07943 Stachybotrys chartarum S40288_07943 N
S40288_09581 Stachybotrys chartarum S40288_09581 N
SAPIO_CDS4869 Scedosporium apiospermum SAPIO_CDS4869 N
SBOR_4456 Sclerotinia borealis SBOR_4456 N
SMAC_00182 Sordaria macrospora SMAC_00182 N
MGU_06147 Metarhizium guizhouense MGU_06147 N
TRIATDRAFT_293894 Trichoderma atroviride TRIATDRAFT_293894 N
TRIREDRAFT_76705 Trichoderma reesei TRIREDRAFT_76705 N
TRIVIDRAFT_113690 Trichoderma virens TRIVIDRAFT_113690 N
UV8b_3402 Ustilaginoidea virens UV8b_3402 N
VDBG_01884 Verticillium alfalfae VDBG_01884 N
VHEMI05419 Torrubiella hemipterigena VHEMI05419 N
X797_007680 Metarhizium robertsii X797_007680 N
estExt_Genewise1Plus.C_70270 Neurospora discreta estExt_Genewise1Plus.C_70270 N
fgenesh1_pm.sca_54_chr3_4_0000024 Nectria haematococca fgenesh1_pm.sca_54_chr3_4_0000024 N
vad-6 Neurospora crassa NCU09205 N
estExt_Genewise1Plus.C_110189 Cryphonectria parasitica estExt_Genewise1Plus.C_110189 N
FPSE_05593 Fusarium pseudograminearum FPSE_05593 N
ACRE_090530 Acremonium chrysogenum ACRE_090530 N
BBA_05678 Beauveria bassiana BBA_05678 N
BBA_09096 Beauveria bassiana BBA_09096 N
Bcin08g05570 Botrytis cinerea Bcin08g05570 N
CCM_07309 Cordyceps militaris CCM_07309 N
CGGC5_7812 Colletotrichum gloeosporioides CGGC5_7812 N
CH063_07963 Colletotrichum higginsianum CH063_07963 N
Cob_02607 Colletotrichum orbiculare Cob_02607 N
CPUR_04593 Claviceps purpurea CPUR_04593 N
CSUB01_00007 Colletotrichum sublineola CSUB01_00007 N
FFUJ_05577 Fusarium fujikuroi FFUJ_05577 N
FGRRES_16399 Fusarium graminearum FGRRES_16399 N
VDBG_01884 Verticillium albo atrum VDBG_01884 N
FVEG_13110 Fusarium verticillioides FVEG_13110 N
GGTG_04996 Gaeumannomyces graminis GGTG_04996 N
GLRG_02657 Colletotrichum graminicola GLRG_02657 N
HMPREF1624_04976 Sporothrix schenckii HMPREF1624_04976 N
MAC_07722 Metarhizium acridum MAC_07722 N
MAC_08257 Metarhizium acridum MAC_08257 N
MAJ_06521 Metarhizium majus MAJ_06521 N
MAM_07708 Metarhizium album MAM_07708 N
MANI_114498 Metarhizium anisopliae MANI_114498 N
MBR_06341 Metarhizium brunneum MBR_06341 N
MGG_09002 Magnaporthe oryzae MGG_09002 N