IRF8 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000140968 T244082_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF8
M03335_2.00		 Homo sapiens
HCGAAACYGAAACY
RGTTTCRGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_1		 (Direct) (Direct)
IRF8
M03336_2.00		 Homo sapiens
HCGAAACCGAAACT
AGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_2		 (Direct) (Direct)
IRF8
M05541_2.00		 Homo sapiens
NYGAAASYGAAASHN
NDSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX		 (Direct) (Direct)
IRF8
M05542_2.00		 Homo sapiens
NYGAAASYGAAASYN
NRSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
IRF8
M05543_2.00		 Homo sapiens
NCGAAACYGAAACYN
NRGTTTCRGTTTCGN		 SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX		 (Direct) (Direct)
IRF8
M05544_2.00		 Homo sapiens
NYGAAASYGAAACYD
HRGTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX		 (Direct) (Direct)
IRF8
M09236_2.00		 Homo sapiens
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B		 (Direct) (Direct)
IRF8
M10890_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ICSBP_Q6		 (Direct) (Direct)
IRF8
M10891_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF8_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irf8
M09246_2.00 		Mus musculus
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A 		0.949 0.949
Irf4
M00175_2.00 		Mus musculus
NNNYGAWASN
NSTWTCRNNN		 PBM
Badis et al.(2009)
Irf4_3476 		0.817 0.817
IRF4
M03334_2.00 		Homo sapiens
HCGAAACCGAAACYW
WRGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF4_1 		0.817 0.817
IRF4
M05539_2.00 		Homo sapiens
NYGAAACYGAAACYN
NRGTTTCRGTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX 		0.817 0.817
IRF4
M07978_2.00 		Homo sapiens
DNDVNNGWWVTGAVWVWN
NWBWBTCABWWCNNBHNH		 ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha 		0.817 0.817
IRF4
M09235_2.00 		Homo sapiens
NDWDRRGGAASTGARAVH
DBTYTCASTTCCYYHWHN		 Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A 		0.846 0.846
Irf4
M09243_2.00 		Mus musculus
NDAWVVRGAASTGARAVH
DBTYTCASTTCYBBWTHN		 Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A 		0.846 0.846
IRF4
M09595_2.00 		Homo sapiens
HNYGAAASYD
HRSTTTCRND		 Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465 		0.846 0.846
IRF4
M10885_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_07 		0.846 0.846
IRF4
M10886_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_08 		0.846 0.846
IRF4
M10887_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5_01 		0.817 0.817
IRF4
M10888_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5 		0.817 0.817
IRF4
M10889_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q6 		0.817 0.817
IRF4
M05540_2.00 		Homo sapiens
NYGAAASYGAWASHN
NDSTWTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX 		0.817 0.817
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000268638 IRF 9 113
ENSP00000455048 IRF 1 56
ENSP00000455784 IRF 9 113
ENSP00000455816 IRF 9 47
ENSP00000456992 IRF 9 113
ENSP00000458047 IRF 9 113

Links

Other IRF family TFs
Other Homo sapiens TFs

166 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CAD25284 Encephalitozoon cuniculi CAD25284 D
CG15696 Drosophila melanogaster FBgn0038833 D
NEMVEDRAFT_v1g80394 Nematostella vectensis NEMVEDRAFT_v1g80394 D
D915_03631 Fasciola hepatica D915_03631 I
ACYPI28321 Acyrthosiphon pisum ACYPI28321 I
A_06265 Schistosoma haematobium A_06265 I
MDOA010523 Musca domestica MDOA010523 I
LCUP001362 Lucilia cuprina LCUP001362 I
YQE_12606 Dendroctonus ponderosae YQE_12606 I
TriadG51739 Trichoplax adhaerens TriadG51739 I
tetur05g02800 Tetranychus urticae tetur05g02800 I
TC015928 Tribolium castaneum TC015928 I
Smp_000075 Schistosoma mansoni Smp_000075 I
H311_03552 Anncaliia algerae H311_03552 I
GK22474 Drosophila willistoni FBgn0224451 I
GJ22956 Drosophila virilis FBgn0210059 I
GM23140 Drosophila sechellia FBgn0178008 I
GL24283 Drosophila persimilis FBgn0161873 I
GI10602 Drosophila mojavensis FBgn0133366 I
GH15916 Drosophila grimshawi FBgn0123387 I
GF17994 Drosophila ananassae FBgn0095012 I
GG24188 Drosophila erecta FBgn0085045 I
GE25692 Drosophila yakuba FBgn0084486 I
GA13896 Drosophila pseudoobscura FBgn0073928 I
Eint_040940 Encephalitozoon intestinalis Eint_040940 I
EHEL_040890 Encephalitozoon hellem EHEL_040890 I